ID A0A423U0L8_PENVA Unreviewed; 723 AA.
AC A0A423U0L8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN ORFNames=C7M84_024593 {ECO:0000313|EMBL:ROT82247.1};
OS Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC Penaeoidea; Penaeidae; Penaeus.
OX NCBI_TaxID=6689 {ECO:0000313|EMBL:ROT82247.1, ECO:0000313|Proteomes:UP000283509};
RN [1] {ECO:0000313|EMBL:ROT82247.1, ECO:0000313|Proteomes:UP000283509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:ROT82247.1};
RA Zhang X., Yuan J., Li F., Xiang J.;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ROT82247.1, ECO:0000313|Proteomes:UP000283509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:ROT82247.1};
RA Sun Y., Gao Y., Yu Y.;
RT "The decoding of complex shrimp genome reveals the adaptation for benthos
RT swimmer, frequently molting mechanism and breeding impact on genome.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROT82247.1}.
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DR EMBL; QCYY01000854; ROT82247.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A423U0L8; -.
DR STRING; 6689.A0A423U0L8; -.
DR Proteomes; UP000283509; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR PANTHER; PTHR21662:SF19; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR PANTHER; PTHR21662; UNCHARACTERIZED; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF01030; Recep_L_domain; 1.
DR SMART; SM00261; FU; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000283509};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 73..214
FT /note="Furin-like cysteine-rich"
FT /evidence="ECO:0000259|Pfam:PF00757"
FT DOMAIN 230..342
FT /note="Receptor L-domain"
FT /evidence="ECO:0000259|Pfam:PF01030"
FT REGION 538..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..559
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..723
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 723 AA; 79050 MW; 1B755C931C7C6967 CRC64;
MTAGSGVRAR GRATQPPSCY SVQHCPRPPS HQHLVSGNAI QPIAVLGNSA RGFRCLPLAE
HLRPRRRNRP QRECPECPPA LGCFRSRRCG APRCWGPQHC QTLCGGECPG GCVGNQCCHE
ECLGGCQRPH SATSCHACRN LLDEGRCTQS CSSPKFKVLQ HRCEERSSCR RNYVIKLDTK
ECVKRCPLGY NLSSNSAGEK LCVPCEGSVC PKECGAAVVK SVSRAQALRG CTVIRGDLTV
NINGGENIER ELEENLGSLE EVTGFVKVFR SNVTSLNFLR NLTRIGGSSL LHSNYSLVIL
DNPHLRALWN WTGRGRRLAV ARGKMFVHSN PRLCFHHIEA LVNATNMTGL SETDVSSTYN
GDKVPCKVTP LEARVTPHLY GTLLVEVATS ARLPPDAVYY VNYKKAEKNV SLYEGDGPCS
DQGWSTTEVG PGNGTALARR RDLIIVNLEP FTRYAVYVKA YSLAASGKGA QSDVLYAVTR
PYHPTEPVGL EWVPRNSSTV ALEWRPPRRP NGRVAHYLPV STSTARCWRW RRPRRSALAR
RKTPAAKEDV RDEGAKVGPE GGEESCQAPP TPSCCACRDA GVSGSEDQEV MGQIAFEDFI
MDNVYVKKVN RSRRTRAADD DDDAAFGSVL WLYQQEQRAE PDAPPRAPRS AAATDDPLGA
WETAASASSG ARRPPSSASI RSCRRGIPGP RRPLRQGVPV ASGHQARVPD SRGEPREVHR
HGG
//
