ID A0A423U638_PENVA Unreviewed; 756 AA.
AC A0A423U638;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 03-MAY-2023, entry version 10.
DE SubName: Full=Putative glycine receptor subunit alpha-4 {ECO:0000313|EMBL:ROT84177.1};
GN ORFNames=C7M84_022627 {ECO:0000313|EMBL:ROT84177.1};
OS Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC Penaeoidea; Penaeidae; Penaeus.
OX NCBI_TaxID=6689 {ECO:0000313|EMBL:ROT84177.1, ECO:0000313|Proteomes:UP000283509};
RN [1] {ECO:0000313|EMBL:ROT84177.1, ECO:0000313|Proteomes:UP000283509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:ROT84177.1};
RA Zhang X., Yuan J., Li F., Xiang J.;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ROT84177.1, ECO:0000313|Proteomes:UP000283509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:ROT84177.1};
RA Sun Y., Gao Y., Yu Y.;
RT "The decoding of complex shrimp genome reveals the adaptation for benthos
RT swimmer, frequently molting mechanism and breeding impact on genome.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROT84177.1}.
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DR EMBL; QCYY01000585; ROT84177.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A423U638; -.
DR Proteomes; UP000283509; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR PANTHER; PTHR18945:SF925; PROTON-GATED ION CHANNEL; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR SMART; SM00192; LDLa; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:ROT84177.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000283509};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 585..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 720..742
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 364..533
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DISULFID 326..338
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 333..351
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 756 AA; 85667 MW; 1ECD7A262478141F CRC64;
MVNHSAPFPF GTPPLEAHMW YHLCLTVNDS VVKLDIGNEE YEVSHQNVAK LPRMGEGDVE
HAYVMLGNNH TSFEFFGQIA DISLYQDPLS QEEIQSFIEC GSDISLGLEY SLDNDVQEHS
QKQARSGLCR PRPDYFAVLF SGLRDQRTSK EFCEHLGARL ASTKDDYSYI LSDIFFSMNA
QSMATVWTED QVDQVADHHV MLFLMKMGNE SSYMNMSISS TTDAANTLCM VPFGKKIYML
RDKREEYTFF SRKGRLVLQG LGSSLIFISK CPGDMEGSCI FYSKKNSRKM YHVYDDNSFL
LGRREWRSLT SKGTQERAIS VTLTACDESQ FTCNNSQCVD LENRCTGMAE CEDLSDEGDT
CRAMDHLPLT YWSNMCPHVS GRPPLIGLFV QLVSINEISL ENNEFKATLT VSTQWKDARL
TFSNLGNCTN KLLPEIYESI WVPAIAFENA NYDDNRHIQQ GTEILQSYTV EADGTNYTDV
LESFEATKNN GTEALLRRTI KYLFKFSCDY EYQLFPFDIQ ECEIVINLPS QTYSCPLAWD
PARIAVFGNS STISTYHVDP VRYVFDPEKG GTVKLKLLFT RKFDAYLLTT FLPCVLLCVL
SELTLFYFDL DAFTDRIAIT LSLLIVLASL FAQVATSMPA SPSPKLVDIF FFYCILRVSL
VFLLHSAIDR KKRDLERKEK EGSSDDVVVL KDLDIKMNIA WSQPSKSEEK AKTTSFINNM
GLVVLMVLDA AAVVGFVVWI LVARATTLAL YDTYSK
//
