ID A0A425W5Z0_9FIRM Unreviewed; 707 AA.
AC A0A425W5Z0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE RecName: Full=Glutamine synthetase {ECO:0000256|ARBA:ARBA00021364};
GN ORFNames=DUD26_02565 {ECO:0000313|EMBL:RRF93244.1};
OS Eubacteriaceae bacterium.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae.
OX NCBI_TaxID=2049045 {ECO:0000313|EMBL:RRF93244.1, ECO:0000313|Proteomes:UP000285774};
RN [1] {ECO:0000313|EMBL:RRF93244.1, ECO:0000313|Proteomes:UP000285774}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EUB1 {ECO:0000313|EMBL:RRF93244.1};
RA Scarborough M.J., Lawson C.E., Hamilton J., Donohue T.J., Noguera D.R.;
RT "Metatranscriptomic and thermodynamic insights into medium-chain fatty acid
RT production using an anaerobic microbiome.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glutamine synthetase family.
CC {ECO:0000256|PROSITE-ProRule:PRU01330, ECO:0000256|RuleBase:RU000384}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RRF93244.1}.
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DR EMBL; QOUT01000002; RRF93244.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A425W5Z0; -.
DR Proteomes; UP000285774; Unassembled WGS sequence.
DR GO; GO:0004356; F:glutamine synthetase activity; IEA:InterPro.
DR GO; GO:0006542; P:glutamine biosynthetic process; IEA:InterPro.
DR Gene3D; 1.20.120.1560; -; 1.
DR Gene3D; 3.30.590.10; Glutamine synthetase/guanido kinase, catalytic domain; 1.
DR InterPro; IPR040577; Gln-synt_C.
DR InterPro; IPR008147; Gln_synt_N.
DR InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR InterPro; IPR008146; Gln_synth_cat_dom.
DR InterPro; IPR027303; Gln_synth_gly_rich_site.
DR InterPro; IPR022147; GSIII_N.
DR PANTHER; PTHR42974; GLUTAMINE SYNTHETASE; 1.
DR PANTHER; PTHR42974:SF1; TYPE-3 GLUTAMINE SYNTHETASE; 1.
DR Pfam; PF00120; Gln-synt_C; 1.
DR Pfam; PF18318; Gln-synt_C-ter; 1.
DR Pfam; PF12437; GSIII_N; 1.
DR SMART; SM01230; Gln-synt_C; 1.
DR SUPFAM; SSF55931; Glutamine synthetase/guanido kinase; 1.
DR PROSITE; PS00181; GLNA_ATP; 1.
DR PROSITE; PS51986; GS_BETA_GRASP; 1.
DR PROSITE; PS51987; GS_CATALYTIC; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000285774}.
FT DOMAIN 72..161
FT /note="GS beta-grasp"
FT /evidence="ECO:0000259|PROSITE:PS51986"
FT DOMAIN 166..597
FT /note="GS catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51987"
SQ SEQUENCE 707 AA; 78761 MW; A22A3BAA63034C3D CRC64;
MSEMLEKKDQ KDSVVDLFGS KVFNVAVMRK RLPKHIYKSV MRTIKYDEPL GREDAEVVAN
AMKDWAMELG ATHFTHWFQP MTGATAEKHD AFISPTGEGS VIMEFSGKEL VKGEPDASSF
PSGGLRATFE ARGYTAWDPT SFAFVKGTTL YIPTSFISYS GEILDKKTPL LRSMKVLSTE
AIRVLKLFGA ADDVHKVTSS VGAEQEYFLV DKDMYAKRKD LILTGRTLFG AMAPKGQEME
DHYFGRIRGR VRHFMRDVDK ELWSLGVPSK TRHNEVAPCQ HELAPVFSSA NQATDNNHLI
METLRRIAPK YDLHCLIHEK PFEGINGSGK HDNWSIATDT GVNLLDPGDD PANNLQFLTF
LIAVIEAVDR YPELLRSTVA SAGNDHRLGA NEAPPAIISI FVGDQLADVL NELLTGKSSG
QAKERTMDLG INATPTFTTD ATDRNRTSPF AFTGNKFEFR MLGSNQSIAG PNIALNTIVA
EVLREYADAL EGSDNFEADC REFLKGRLEA HKRVIFNGNN YTDEWVEEAE KRGLPNLRTT
PEAFAEYCMP KNVEVMSKNN IYTDEEMKAR QEIHLEEYSK TINIEAKTML SMARHEILPA
VMDCEKDLTT VLSQKAAVGI ETKDSVEAVM VEKIAALAKD LLAETDALDA VTEKAAAIED
AQEQANSYCA DVIGAMNTLR ATADELETIV GKEYWPYPIY EDLLFYV
//
