ID A0A426GM57_9CAUL Unreviewed; 506 AA.
AC A0A426GM57;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 12.
DE SubName: Full=Tryptophan 7-halogenase {ECO:0000313|EMBL:RRN65163.1};
GN ORFNames=EIK80_06255 {ECO:0000313|EMBL:RRN65163.1};
OS Caulobacter sp. 602-1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=2492472 {ECO:0000313|EMBL:RRN65163.1, ECO:0000313|Proteomes:UP000268773};
RN [1] {ECO:0000313|EMBL:RRN65163.1, ECO:0000313|Proteomes:UP000268773}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=602-1 {ECO:0000313|EMBL:RRN65163.1,
RC ECO:0000313|Proteomes:UP000268773};
RA Gao J., Sun J.;
RT "The genome of Caulobacter sp 602-1.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RRN65163.1}.
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DR EMBL; RRYI01000002; RRN65163.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A426GM57; -.
DR OrthoDB; 5695497at2; -.
DR Proteomes; UP000268773; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2}.
FT ACT_SITE 80
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 14..17
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 80
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 187
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 335
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 344
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 348
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 506 AA; 56883 MW; 6EFBC39CDE743224 CRC64;
MQDNRIRKLV IVGGGTAGWM AAAALRRHFQ GGPLEITLVE SSEIGTIGVG EATIPTIRAF
YNQLGLTDIE VMRATQATCK LGIRFNGWVR EGQSFIHPFG HFGQDLRGVA FHHYWRKLAQ
AGEPTDIADY SLGASLARAG KFMAPSRNPA STLSVFDWAL HFDASLFAQL MRRVAEENGV
RRVDARVTKV NLRPEDGFVA SLDLHTGESV EGDLFIDCSG FRGLLIEEAL QTGYEHWNDM
LFCDRAWAAQ SEGVGDPMPY TDVTAHTAGW RWRIPLQHRY GNGYVFSSRH IGDEDALAEL
KAAIPDPLLH EPRLIRFNPG RRKQVWNKNV IALGLASGFL EPLESTSIAL IETGIEKIKA
LFPDKDFAPE IVDEFNDWSR REMERVRDFI VLHYWANKRG DTAFWRDCND VVLPEALRRK
VDLFLTRGHF VRYRWEMFAP PSWMAIYAGF ELLPQTVDPS LDGIDPRTLS APLAEMRKAV
REVVANAPPH AAFLDQYCRS AAMAAE
//
