ID   A0A426VCH6_9BURK        Unreviewed;      2005 AA.
AC   A0A426VCH6;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   03-MAY-2023, entry version 10.
DE   SubName: Full=Alpha-2-macroglobulin {ECO:0000313|EMBL:RRS04567.1};
GN   ORFNames=EIP75_09045 {ECO:0000313|EMBL:RRS04567.1};
OS   Aquabacterium soli.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Aquabacterium.
OX   NCBI_TaxID=2493092 {ECO:0000313|EMBL:RRS04567.1, ECO:0000313|Proteomes:UP000269265};
RN   [1] {ECO:0000313|EMBL:RRS04567.1, ECO:0000313|Proteomes:UP000269265}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SJQ9 {ECO:0000313|EMBL:RRS04567.1,
RC   ECO:0000313|Proteomes:UP000269265};
RA   Sun L., Gao X., Chen W., Huang K.;
RT   "The whole draft genome of Aquabacterium sp. SJQ9.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000256|ARBA:ARBA00010556}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RRS04567.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; RSED01000006; RRS04567.1; -; Genomic_DNA.
DR   OrthoDB; 9767116at2; -.
DR   Proteomes; UP000269265; Unassembled WGS sequence.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR   PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF11974; bMG3; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000269265};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..37
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           38..2005
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5019570868"
FT   DOMAIN          1061..1244
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          1302..1400
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
FT   REGION          837..872
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1481..1502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2005 AA;  219325 MW;  B240ACB48846050D CRC64;
     MRSGAIFGLT VSLARRPLLA CLPGLTALLS CLPAAYAATV VQSTPQGEVT QVRQVVVRFD
     QAVVPLGDLR QDAPYGLECQ GAASKGEGRW INDRQWVYDF EQDLGPGVRC QAKPRTNWRP
     AVSAAGTWNQ PKAFAFQTGG PAVVRVSPSG GEVEEQQHWL FTLNGPALPA SLKDKAWCEV
     EGVGERLPLE VVTGAPREAV LKSRGLKTGD ERQLLVRCQR PLPNQAAVRL VWGAGIAAKS
     LPQAVTRQAQ QFDFNVRPAF EVEFSCEREK AQAPCLPLRP LTVRFSAPVP RALAEQVRIE
     RDGSDALKPW FDKDDKRDTV EELTFKAPLP ENANLAVVLP AKLKDTADRS VANAHAFPMA
     VRTGGMPPLA KFATAPFGVV ELESDPGQPP LLPITVRHVE ADLGIKTLDA SKAGLNGKSK
     TLTQDIDILR WIAKVQKHHE TSFSAKELGR PASQWKEWRI ERDGNGREIR YETERRIGAR
     ELSLLNAEKQ TQPLKLPPTD AKDTRPFEVV GIPLPGPGYH VVEVASPRLG ASLLAQPAPM
     YVRTGVLVSN LGVHFKLGRE NSLVWVTTLD KARPVPGADV AISNCRGEPL WKGRTDAQGR
     AVVNQPLAVS RYEGCLVDNG LFVSARKAID QGPYKGQTDL AFAFTDWNKG VEPWRFNVPT
     ASPEYTNTAD EMRVHTVTDR ALLRAGETVS MKHFARVETR HGLAALPRER WPASLRIVHT
     GSGDEITQPL TWRPNGTALS TWAIPQDAKL GVYEVYLRGQ GPGSQYGTLA GQFRVEEFRL
     PLIQARVAGP KDLQVSPAEL PLSVQMSFLS GGGFGGAPGR VSALLRERNV HFARYDEFNF
     EPPRAPRDNA QASNDDDNGD EGDPGQAAGG RLIADKLPLV TDREGNARIV LPKLPPTRRP
     MAVQAELSFN DPNGEVQTVS TEVALWPSQV VLGLKTGSWA STRGQVKFQA LALDTTGKPL
     PKQDIKVIAR VSQHLSTRKR IVGGFYSYDN RTEVKDLGTV CSGQTDARGL LLCEAELDSA
     GEVELVAQAK DARGNAAEAA TTVWVTRHGE LWFSQDNDDR MDVLPEKKSY EPGETARLQV
     RMPYREATVL VTVEREGVID SRVLTLKGDD PTIELPIPKA TSWAPNVFVS VMALRGRVHE
     VPWYSFFTWG WRKPLAWWDA YWNEGRQYQA PTAMVDLSRP SFKLGVAQLH IGRALHELDV
     AVTPDKQRYS IRQTVRTKVR VTQGGQPVQG EVAFAAVDEA LLALADNPSW KLLDGLLQDR
     AWGVQTSTAQ NEIIGRRHYG RKAIAPGGGG GHSASRELFD TLLLWRGDVA LDANGEAVID
     VPLNDSLTSF RLVAIAQGPG RLKTSPPQEA FGTGSASVQV SQDLRMLSGL PPLVREGDRF
     DALFTLRNTT GQPMKVRAEL KPAEGNTTPP PTAQEVDVPA QGAREIRWTL TVPAGITALH
     WQASATTARP GVADRVTLKQ QVQPAVPERM LQATLRQLDG PLSLPVQPPA DGLTLPTPEG
     TRARGGVRIE VQPKLTGALP GLRRYFETYP FVCLEQQTSK AVGLKDAALW DSVAKRLPTY
     LDSDGLALYF PPSAGDAPRG NDRLTAYLLA ATHEAGFALP DKPREQMLEG LTAFVQGRVM
     RESWSPSGRP QTLNLAVRKL AAIEALSRYG RAEPRMLDSV TIEPQIWPTA ALIDWLNILQ
     RLDGIPSRDQ RLAEAENTLR ARLTYAGTTL KFSTEADDFW WWLMDSADAN AARLILAVID
     RPGWKDELPR LVTGSLGRQR QGAWLTTTAN LWGSLALDKF SQRFENVPVT GTTVTQLGGV
     SLSHNWSAQP QGGGQRLPWP VVPANQRAAI TPLTAQQQGT GKPWLTVQAL AAIPLKAPLS
     AGYRVQRQVS IVDGDELKPV PAGPLPRGTL LRVRLVVDAQ SDMTWVALND PIPAGSTVMG
     SGLGRDSALS TRGETQQGIW PAYVERRFDA YRAYYEWMPK GHHEIDYTVR LNNPGSFQMP
     PTRIEALYAP DSFGEAPNAV VEVKP
//