ID A0A427XSJ1_9TREE Unreviewed; 2333 AA.
AC A0A427XSJ1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=Mitochondrial escape protein 2 {ECO:0000256|ARBA:ARBA00020222};
GN Name=YME2 {ECO:0000313|EMBL:RSH81819.1};
GN ORFNames=EHS24_008011 {ECO:0000313|EMBL:RSH81819.1};
OS Apiotrichum porosum.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Trichosporonales; Trichosporonaceae; Apiotrichum.
OX NCBI_TaxID=105984 {ECO:0000313|EMBL:RSH81819.1, ECO:0000313|Proteomes:UP000279236};
RN [1] {ECO:0000313|EMBL:RSH81819.1, ECO:0000313|Proteomes:UP000279236}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 27194 {ECO:0000313|EMBL:RSH81819.1,
RC ECO:0000313|Proteomes:UP000279236};
RA Aliyu H., Gorte O., Ochsenreither K.;
RT "Genome sequence of Apiotrichum porosum DSM 27194.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in maintaining the mitochondrial genome and in
CC controlling the mtDNA escape. Involved in the regulation of mtDNA
CC nucleotide structure and number. May have a dispensable role in early
CC maturation of pre-rRNA. {ECO:0000256|ARBA:ARBA00025276}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}.
CC -!- SIMILARITY: Belongs to the YME2 family.
CC {ECO:0000256|ARBA:ARBA00010320}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSH81819.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; RSCE01000006; RSH81819.1; -; Genomic_DNA.
DR STRING; 105984.A0A427XSJ1; -.
DR OrthoDB; 1384689at2759; -.
DR Proteomes; UP000279236; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR018850; Mt_escape_2_C.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR039627; Yme2_C.
DR NCBIfam; TIGR00756; PPR; 2.
DR PANTHER; PTHR32198; MITOCHONDRIAL ESCAPE PROTEIN 2; 1.
DR PANTHER; PTHR32198:SF2; MITOCHONDRIAL ESCAPE PROTEIN 2; 1.
DR Pfam; PF13041; PPR_2; 1.
DR Pfam; PF13812; PPR_3; 1.
DR Pfam; PF10443; RNA12; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51375; PPR; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000279236};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REPEAT 650..684
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 792..826
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT DOMAIN 1766..2265
FT /note="Mitochondrial escape protein 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10443"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1514..1541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1127..1149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2333 AA; 261823 MW; 0B1C1B61923F163B CRC64;
MAATPFALPP PATTASTRAR AGPGRANLLP SLSWLDAPRR FSVWAPKVKE HLDTQASSSK
PNYPRTIRFL HHTAASPSSP LPSRPLKQCS RLSNKYPFSL QHPLPSFPSS AMACRAPQAI
VMSGRLPPST VTHVLRLVGT SYLDNGAGPS RRAFKVLPRT LLVHPTVATL QASRRFVSSA
PAPPPADSDE TTVVPTPERR PRDPNHPRFS SDPEVRRTST EPAWARLPED KRQRLFGDAP
RPSPTQFREW FDALENPAMI LPADRLVAVL KVFSTTETTQ DDWKWLGLVL AEANRKENWQ
WAKLPGSEQM FRLLRGLSFA HCEKWDAAAT NMALGLKASL VAGDLNQQFR WLRTPELDAL
EEYTVMLWMK RRVEDIGRVV RYAGPHWHKT LLLIPGTRDI HPSARRAQEI VFTALNQIRD
PAKYITVQIE DREHASNSVY TLAIILLTGL VSDRLRSSDA FTFWNHIIKH RGAVKFISPF
LGSKLAINLS SDKKNLAAKE VFKTLYETFP KLSHSVLSRQ LQFHSMDGDQ QQVQVVWAKI
TKSFKPTTND RIWVASVFAA TGDIDATRKA LRSLFGAGYT EDVDALCILT QAFIAAREAE
PAFAVIKKIN TIQPRLAPHH QLLRLYAAQA DAANAINVFD TIIQAGLSPT EPCYNTLLSV
FANTADYAHA QEVFNAMVRA GVEPSAKAWT SLVNSYIEAG EFGGAAALSD KIPLEHYLDD
GMSTAIMKAF VYVSAPLPQV VRIFRQLRYP SAQAWALMIQ SAADCQDMDL ARSIFEEMDA
RATVDCLSPK PNVYVFSILL HAYLRKHDRE SSRAVYDAMI ERGIVPTSVT YAIITNSYAK
SKDPNSFQQA HDFATSVVSN LSPDEKTTAR GKPAENVFGP LIIAAGKAGD LSRAKSYYET
VRASGGTSVI LTSQLMNAYR HARQPHEVYR LWLRLFKDTM RAIPRKTPSD KAFKVTRSRN
NVLCVPLSIM IRTLADTGDH GRLKKVWHAV RTAGFGVDAA NYNHFAAASA QTGDIEGAFH
IIDRVIMPRY DEVREREYRD MRTANGLAGV NLARSSDDPE LVYGPFREIS PNTITHRLPE
IPVDRGNTWG RFILAQRRHA MNIIRRNYYE KYPADDPQVL TNDDVADPDF RPNRRYRRRS
RKVPDFEHDP DQPTAVNTEI MSHWRPTDIM WRPDERTLKV INQAFLQLQI ENRRRVTERK
LAVFGDSAKL LPQYGNRHAP EYRKALLEGR KAYREAEAAE PPTPVTLPYF NFNPTVVNYD
GTVKLITPHA MIARIRRKYP RIVQMMMWHR RKNRLRTGRV RIRKALRKRR QLAWQKKRRW
LDYQRKRRCT YIGSGAGVAP RHTVAVGSLG YQHHRTHSTA PPVAIASETP EEITVPEREH
ASFYISNVLP IQVSSLDPRP SIARLREETL LDDLIAITNE LRGTHAFRVE SWEVARKDGG
FFCHFSYLPP CAADLPRHVH DPAIHTPEDV AVEPTSPASL FLPRLIDAAH KHGGWPHWAG
QWWANFIARD STNSRTTDEA GHHLYRGDTP PGQPRPPEDV PQLQGWQRVA GIGRIWIVRG
RQWTEDLYRF PSSRLRVEFD GPDVSQEMLY RLFRPYGRLL EIIPPAPVPA GNLRFALLHF
SRITTSVTAS NCLHGYNSPI KSADYDLRKS GADGEEGSKV PSSRLRIYYE RPLKAHYIRD
WIRDHPRISL PVLAFLIATL SYTFFDPIRS FFVSSNIEGV FNIEEYPVVK FVRENVWAPL
MKLVGSNRRV NRRNVEHLGR ASWEDRLEAE KSIQNWLSEF PSTFIVVLGP PGSGKHDLVD
HVIKQEKKPA LVIDCAEMAK AKTDSALISA LADQTGYWPV FSFLQSVNGL IDLASVGLIG
QKAGFSTPCD QQERSMLDIV SGALKDTSVH AQKGRVEKQE CAEDRINMAA DREHKRHMIE
MGVWHDGRLD CVAGNGVMSE LGVGIEEPTI YDMPATPAPL MGSNAPIDGE GVPPQTPARF
SEITAAIQQA AEENVDPQAD AIATLPIVVL RNFSAKHARG DMWNVLAEWG ASLIENKIAH
VIVVGEGSIT TKTLTQALPS KPLDSVTLAD ADDYNSLEFV REKLSTNDQP YKLSDADKMD
ISKLGGRMVD LELLVYKTRG GQSINDAVDD IVVRNVIEIR KAAFGDDTAE AKGLPWTRPQ
AWKIINELSK KGELPYGKLL VDWPFKGQEP SLRALEEHDI ISISYTEGRP STVRPGKPVF
RQAFNRLVSD PPFRASSQIE YNNAFITKIE TDIAAIEAEL AQLRSITAEG DKLGVGEGGW
FGMTKGSGIH QRAQYLLAKL ETLMTKLRNA DADSDAQKLV FSAPRPKPKP STA
//
