ID A0A427YEH5_9TREE Unreviewed; 729 AA.
AC A0A427YEH5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Integrase catalytic domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=EHS25_002476 {ECO:0000313|EMBL:RSH89364.1};
OS Saitozyma podzolica.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Trimorphomycetaceae; Saitozyma.
OX NCBI_TaxID=1890683 {ECO:0000313|EMBL:RSH89364.1, ECO:0000313|Proteomes:UP000279259};
RN [1] {ECO:0000313|EMBL:RSH89364.1, ECO:0000313|Proteomes:UP000279259}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 27192 {ECO:0000313|EMBL:RSH89364.1,
RC ECO:0000313|Proteomes:UP000279259};
RA Aliyu H., Gorte O., Ochsenreither K.;
RT "Genome sequence of Saitozyma podzolica DSM 27192.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|ARBA:ARBA00024557};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSH89364.1}.
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DR EMBL; RSCD01000014; RSH89364.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A427YEH5; -.
DR STRING; 1890683.A0A427YEH5; -.
DR Proteomes; UP000279259; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR42648; TRANSPOSASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR42648:SF11; TRANSPOSON TY4-P GAG-POL POLYPROTEIN; 1.
DR Pfam; PF14223; Retrotran_gag_2; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Reference proteome {ECO:0000313|Proteomes:UP000279259};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464};
KW Transposition {ECO:0000256|ARBA:ARBA00022578};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 273..289
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 508..686
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 50..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..267
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 729 AA; 79482 MW; 77EA8A3B57CFC84B CRC64;
MSTDSATPTT LSAVPKLRGN ANYIEWREAI EEQLLAHDLL DIVEGTEEEP FGQKGVRKRR
AGSVMPTGGT GDPGDAPKAL SAVEVKQWKD WSKRESKAQA WLRMTCTEGP KRSIMGMLSA
HEMWSHLENT HMVRTIERQG QLLQTLASFR LLSANSKAMT THMESFLVTL SRYETAGGIL
PESQQIVLFL NSLPAAMEQW KDTYAALDEY RQTWVELERL WNRKVEDKER YETSKGSHSN
GDALATHGGN HGQKGKKTGE KKEKKQRDMS KVKCWTCEKT GHFKRDCPDA EDSSKKDKTD
GQANAAVEAE FEAFVGQAVQ DATGLDSEWV IDSGATHHLS GDPKVFASRS DLPEPFSFSL
AGQGSLTAEQ MGEVPLRLPS GHGLSLQDVY FTPSARLNLL SASRLLSRGW TISLAPSGGR
ISNGKVDVPL EKRKGLWVLT AKSANQPTHG RVLVTTGAES LHAALGHIRG KKLEDAAAQA
GLKVADVMRS AEGCSTCAEA KATKQPKAGT SPRGAYAGEL VHVDIAGPFQ PAKAGEDHFL
ALVDDWSKIS LVVPMGGKTE AYRHLRAFVS IMARLAAPRA VRFVRSDGGG EFGSLEAQAW
YRETGIQHQV SPPYTPELNG VVERFMRTAK EMITAMLKGS ALPHEYWTHA ARHAACIIMK
TTKVQGKTAW ERLTGREPTL PTSRVFGQSI TVAIPRAVRT KGSLTNARGV RGTLAQGIGL
GSLLQSSDQ
//
