ID A0A427YK52_9TREE Unreviewed; 1350 AA.
AC A0A427YK52;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
DE AltName: Full=Mediator complex subunit 13 {ECO:0000256|ARBA:ARBA00032008, ECO:0000256|RuleBase:RU364134};
GN ORFNames=EHS25_009756 {ECO:0000313|EMBL:RSH91457.1};
OS Saitozyma podzolica.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Trimorphomycetaceae; Saitozyma.
OX NCBI_TaxID=1890683 {ECO:0000313|EMBL:RSH91457.1, ECO:0000313|Proteomes:UP000279259};
RN [1] {ECO:0000313|EMBL:RSH91457.1, ECO:0000313|Proteomes:UP000279259}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 27192 {ECO:0000313|EMBL:RSH91457.1,
RC ECO:0000313|Proteomes:UP000279259};
RA Aliyu H., Gorte O., Ochsenreither K.;
RT "Genome sequence of Saitozyma podzolica DSM 27192.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex.
CC {ECO:0000256|ARBA:ARBA00025661, ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSH91457.1}.
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DR EMBL; RSCD01000008; RSH91457.1; -; Genomic_DNA.
DR STRING; 1890683.A0A427YK52; -.
DR Proteomes; UP000279259; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000279259};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 914..983
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1070..1260
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 379..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..627
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..676
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..729
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1350 AA; 146506 MW; 7600EB307F036AF8 CRC64;
MPPPASDFLG GQPAFPNTLV PGRWLVDLPS SSSTIFIRRY RPLAHDQVAE ALADGLKRGN
GDALLGRLGQ EALEEGWRAV NGSGPSSTGD VDKVLRGGCG VIVRAEPESE GDESEAMMPR
DALQAKNKNK NENSTNVRTG HSGSPSLIHL HVAIHLLHAA WPRPGLSHSV EWRSRRVRRY
LLDIFGHGAA LGISYRCGGG EVGMAHGSEA VDAPQTELEL VISVQCLPPP DIGNTLAPLA
IPSKATIRLS ALHPTAAQQS RLTTLFDTVL SPSWKASRPE RRLAAHLAGQ QWTDWSIYWV
PTPSPQDAAD ITQLLPQQVM SHWQQRSGIL TVWPTSLTSE LSPPRPTALK RKHEAAPDFT
VPPITDLLYT AFGLFESLTA AKPPEPEEPV KEESEMADEG RPIELTPEPL FDEDGVGSPK
SDLDDLFSDN GDASPPTDEN GDASGGSPVG GETETGQAQD DLFGGDESAA VIEGDVPMED
DVPVAYEAQE RGMDDRPDDT MMITEDDFAF FDTPAVSPEA SAAIEQVMET RPPPPVELPT
VHEVAEEAIE ETKPPEAPVN GGAADVVEQP SEQPPEPETN IVAGEDAAAP PPLRATPSTS
PQVRFAELPP ESARSPSPQP PSPEQQIIPC EFEPVALPSN TLPSLNYAFP SPAPTPESLR
SDLVERLQKQ PAKKAKYDYA ADWATQDEPS EIDEDESYTG APPTPESDDD MELSRESTPE
AKQDLVRDGD EVEFGGIRCI GAEWAWIKDE PEMLNALARQ WNQGWIAAGK ANPTGALPPS
PAPSPPDGNA ECLANMDIDR LAGELISNRH FRQLLLPETF TADALDESDP LTKTGTPLSQ
LMPPSDDSSQ IDDDIALAFL DTSDAIVEAV AVAEPKPLAM VNIHAGFAGY VTRLSIASLS
YWRQLGLVPV GGKKDVSAVM ICDAGEDSKR AAERLMTKLG ATYETLGLGS HRPLETAKTP
DGIAAVQASA FVETLDEVLR GYSDSSDHLI VYVFFNNMAA ATSPAALQLL FSSRPTPPTC
SIHILTPTAI QMRHLQPIVR EVYNRISRQI RRIEEYGHTL DEPPVWMRYP SFTLAPDQPP
KMQLTLTWPL RSYDLLNKWR LVHGAYAYDK DLEIVIAFVI DSEGESHEVR TWRTKDMGMR
ERLQRLWDFF RVFADKAAIE WRMSICRLGA MSSDEAEVWG DIPRPRTAAL SLLMVLDPPS
PGPAISRPRP AVPNITAAML NDTSTRIIDE SLTAYLTTST QRLPVDLPDS SGTSSTSTQS
VYPKSSFVLS VATPGAVGGE NISAAYQILS HVAAPGKEKE SVGEILGREF YRLLCLGRVR
YGFEGSGMPV HLEAVRAVLE GMRTMSNGTR
//