GenomeNet

Database: UniProt
Entry: A0A427YK52_9TREE
LinkDB: A0A427YK52_9TREE
Original site: A0A427YK52_9TREE 
ID   A0A427YK52_9TREE        Unreviewed;      1350 AA.
AC   A0A427YK52;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
DE   AltName: Full=Mediator complex subunit 13 {ECO:0000256|ARBA:ARBA00032008, ECO:0000256|RuleBase:RU364134};
GN   ORFNames=EHS25_009756 {ECO:0000313|EMBL:RSH91457.1};
OS   Saitozyma podzolica.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Trimorphomycetaceae; Saitozyma.
OX   NCBI_TaxID=1890683 {ECO:0000313|EMBL:RSH91457.1, ECO:0000313|Proteomes:UP000279259};
RN   [1] {ECO:0000313|EMBL:RSH91457.1, ECO:0000313|Proteomes:UP000279259}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 27192 {ECO:0000313|EMBL:RSH91457.1,
RC   ECO:0000313|Proteomes:UP000279259};
RA   Aliyu H., Gorte O., Ochsenreither K.;
RT   "Genome sequence of Saitozyma podzolica DSM 27192.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC       regulatory module of the Mediator complex which is itself involved in
CC       regulation of basal and activated RNA polymerase II-dependent
CC       transcription. The SRB8-11 complex may be involved in the
CC       transcriptional repression of a subset of genes regulated by Mediator.
CC       It may inhibit the association of the Mediator complex with RNA
CC       polymerase II to form the holoenzyme complex.
CC       {ECO:0000256|ARBA:ARBA00025661, ECO:0000256|RuleBase:RU364134}.
CC   -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC       the Mediator complex. {ECO:0000256|RuleBase:RU364134}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU364134}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC       {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RSH91457.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; RSCD01000008; RSH91457.1; -; Genomic_DNA.
DR   STRING; 1890683.A0A427YK52; -.
DR   Proteomes; UP000279259; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR009401; Med13_C.
DR   InterPro; IPR041285; MID_MedPIWI.
DR   PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR   PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR   Pfam; PF06333; Med13_C; 1.
DR   Pfam; PF18296; MID_MedPIWI; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU364134};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW   Reference proteome {ECO:0000313|Proteomes:UP000279259};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU364134};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU364134}.
FT   DOMAIN          914..983
FT                   /note="MID"
FT                   /evidence="ECO:0000259|Pfam:PF18296"
FT   DOMAIN          1070..1260
FT                   /note="Mediator complex subunit Med13 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06333"
FT   REGION          379..480
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          547..729
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          826..847
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        385..408
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        613..627
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        662..676
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        708..729
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        832..847
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1350 AA;  146506 MW;  7600EB307F036AF8 CRC64;
     MPPPASDFLG GQPAFPNTLV PGRWLVDLPS SSSTIFIRRY RPLAHDQVAE ALADGLKRGN
     GDALLGRLGQ EALEEGWRAV NGSGPSSTGD VDKVLRGGCG VIVRAEPESE GDESEAMMPR
     DALQAKNKNK NENSTNVRTG HSGSPSLIHL HVAIHLLHAA WPRPGLSHSV EWRSRRVRRY
     LLDIFGHGAA LGISYRCGGG EVGMAHGSEA VDAPQTELEL VISVQCLPPP DIGNTLAPLA
     IPSKATIRLS ALHPTAAQQS RLTTLFDTVL SPSWKASRPE RRLAAHLAGQ QWTDWSIYWV
     PTPSPQDAAD ITQLLPQQVM SHWQQRSGIL TVWPTSLTSE LSPPRPTALK RKHEAAPDFT
     VPPITDLLYT AFGLFESLTA AKPPEPEEPV KEESEMADEG RPIELTPEPL FDEDGVGSPK
     SDLDDLFSDN GDASPPTDEN GDASGGSPVG GETETGQAQD DLFGGDESAA VIEGDVPMED
     DVPVAYEAQE RGMDDRPDDT MMITEDDFAF FDTPAVSPEA SAAIEQVMET RPPPPVELPT
     VHEVAEEAIE ETKPPEAPVN GGAADVVEQP SEQPPEPETN IVAGEDAAAP PPLRATPSTS
     PQVRFAELPP ESARSPSPQP PSPEQQIIPC EFEPVALPSN TLPSLNYAFP SPAPTPESLR
     SDLVERLQKQ PAKKAKYDYA ADWATQDEPS EIDEDESYTG APPTPESDDD MELSRESTPE
     AKQDLVRDGD EVEFGGIRCI GAEWAWIKDE PEMLNALARQ WNQGWIAAGK ANPTGALPPS
     PAPSPPDGNA ECLANMDIDR LAGELISNRH FRQLLLPETF TADALDESDP LTKTGTPLSQ
     LMPPSDDSSQ IDDDIALAFL DTSDAIVEAV AVAEPKPLAM VNIHAGFAGY VTRLSIASLS
     YWRQLGLVPV GGKKDVSAVM ICDAGEDSKR AAERLMTKLG ATYETLGLGS HRPLETAKTP
     DGIAAVQASA FVETLDEVLR GYSDSSDHLI VYVFFNNMAA ATSPAALQLL FSSRPTPPTC
     SIHILTPTAI QMRHLQPIVR EVYNRISRQI RRIEEYGHTL DEPPVWMRYP SFTLAPDQPP
     KMQLTLTWPL RSYDLLNKWR LVHGAYAYDK DLEIVIAFVI DSEGESHEVR TWRTKDMGMR
     ERLQRLWDFF RVFADKAAIE WRMSICRLGA MSSDEAEVWG DIPRPRTAAL SLLMVLDPPS
     PGPAISRPRP AVPNITAAML NDTSTRIIDE SLTAYLTTST QRLPVDLPDS SGTSSTSTQS
     VYPKSSFVLS VATPGAVGGE NISAAYQILS HVAAPGKEKE SVGEILGREF YRLLCLGRVR
     YGFEGSGMPV HLEAVRAVLE GMRTMSNGTR
//
DBGET integrated database retrieval system