ID A0A427YUB0_9TREE Unreviewed; 1477 AA.
AC A0A427YUB0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Sterol regulatory element-binding protein cleavage-activating protein {ECO:0000256|ARBA:ARBA00019541};
GN ORFNames=EHS25_004467 {ECO:0000313|EMBL:RSH94662.1};
OS Saitozyma podzolica.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Trimorphomycetaceae; Saitozyma.
OX NCBI_TaxID=1890683 {ECO:0000313|EMBL:RSH94662.1, ECO:0000313|Proteomes:UP000279259};
RN [1] {ECO:0000313|EMBL:RSH94662.1, ECO:0000313|Proteomes:UP000279259}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 27192 {ECO:0000313|EMBL:RSH94662.1,
RC ECO:0000313|Proteomes:UP000279259};
RA Aliyu H., Gorte O., Ochsenreither K.;
RT "Genome sequence of Saitozyma podzolica DSM 27192.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WD repeat SCAP family.
CC {ECO:0000256|ARBA:ARBA00007410}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSH94662.1}.
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DR EMBL; RSCD01000002; RSH94662.1; -; Genomic_DNA.
DR STRING; 1890683.A0A427YUB0; -.
DR Proteomes; UP000279259; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:InterPro.
DR GO; GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR030225; SCAP.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR46378; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR46378:SF1; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000279259};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT TRANSMEM 320..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 318..484
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 22..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1062..1164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1275..1297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1341..1364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1407..1477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1345..1364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1455..1477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1477 AA; 156015 MW; 092D355BF1E5C45A CRC64;
MTNLFYPSLA LYLQKRSDAL HSASPSSSYR MPLQDQAGPS RRIRRDHPLS FLSAPLLDTF
FPYPPPLLPR LPWYGWWDAS RSDDSREDED GWRASRVGAG EKGIGGDADA EEEVRLLRVG
WADVGDVLDG QGEAGQQEWT EKDDVVLSLV RDMVEQWEDD YPDAGEHCVR RLLPTNHDRH
KGDAGPCYLV SPSSKSANGD WEGDDVLTLE TLAGKSLVQG SGPNTNGSMS DTGSIYHSVA
ALFHVPCASA VDFESRWSSS LAQLAGKLSG EVFVEAHGPG QRGVDQVDQW SLSYHPHSSS
SAVSPSDPKS PDGLSSSPPW AVWILYLLLF SVLGRQLSNA SKVHSRFGLA FTGIVQLCCS
SVMSFSVLAL LGWNGWGTSS TPRTLPTYML PFVIVIVGAE NMSTLTRAVF SIPFTYSVPV
RIGLALNKVG TTISLTSLTD LVLLFVVWLC VNLRPVREFC VFAAVVIITD WFMLHTFFLT
ILSIDAQRLE LADVLAPPKQ SAPSPTVEKT TEAEDGTRVA ESAWRKVLRA RSARVFSLFA
LLSSIGVLYY LTERHRSPHR TIANLYGYTP TQTSSTGSVS APTAFSTAVT DLLSLSPSEA
LWRSLNPSGW PSVLLSVPPA SLFVLPTPGH AMLPADLRKL SVKTSRLPLP RLRPLLYLLK
VLVLPQAVTA GLLYILLLYL LKDADLLDAQ RNRLGRGEVA SDEGMDSSTG LPSITSRGRS
QLAANLGVHM LPCSHAADLD LIASSKDVAL VMSVGIDNTL CLWRFAEDGS VSGTRETLSA
EGLRTSDPVV AALVGSDGRD LAVCTVSGTV QRWTISEEGA VVALPGTNIP SQARIVGFTF
DDSLATTSSD DPFMARPVSP ATTLKAPALL VACGNGEVFA VDATGAVSTI ISASSSSTCK
VFFLPANPGA DVSLNIVVAT AERVDCFRKT SAGWTSYGIQ ATLDASDRIT AADRLVMGDA
ATTFVALGHR SGFVEIFDSE GSLLVTTDVV GEPIRSVRLS SPASSKCFGC AANLNEGLFV
ISSTISHVYV DRVHPRSAPI CRCPQPRRSS SIEDLAHRDS ATPSKMALSG SGPGLVVPPT
SIRRSSPGNS PRKSPGLLPP VSNGEFPLSS HGTRRLSTMH RDDMSPRPPS PGERSPAMLF
TPTTRHGHGH GHGHGGVSAA SSGPSTWTDL EVTAMGGVRC TSGGAVLLGN HLDKVVGLRR
FGSGIDEAGW QVWTLDLCSP WNGTMLVVER APLDWLVRRT MTRRPTLSGS ANEGETSMRD
RRAERLLGLS GRASFTSQSQ TNFGGGRAGG GGGGSASGSF AVPTHPGLAY VQVHPIVSRD
PTSLVAGFGN RLGVVVLPES SGKDKSKFGS LNKTSGVSAA TATSTTSATP ATTAPAAAAV
TAATATGGGG PGITLSRRSV GGLGIGGVQN AGPSGTQGIT PPPPARRSVG DLHLQITTSD
PPVSPVLPVG RTSGVGSGQV ASNMSSMSSN GTDRKNI
//