ID A0A428PJ44_9HYPO Unreviewed; 1520 AA.
AC A0A428PJ44;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
DE AltName: Full=Mediator complex subunit 13 {ECO:0000256|ARBA:ARBA00032008, ECO:0000256|RuleBase:RU364134};
GN ORFNames=CEP53_007897 {ECO:0000313|EMBL:RSL53040.1};
OS Fusarium sp. AF-6.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium solani species complex.
OX NCBI_TaxID=1325737 {ECO:0000313|EMBL:RSL53040.1, ECO:0000313|Proteomes:UP000287544};
RN [1] {ECO:0000313|EMBL:RSL53040.1, ECO:0000313|Proteomes:UP000287544}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL62590 {ECO:0000313|EMBL:RSL53040.1,
RC ECO:0000313|Proteomes:UP000287544};
RA Stajich J.E., Carrillo J., Kijimoto T., Eskalen A., O'Donnell K.,
RA Kasson M.;
RT "Comparative genomic analysis of Ambrosia Fusariam Clade fungi.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex.
CC {ECO:0000256|ARBA:ARBA00025661, ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSL53040.1}.
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DR EMBL; NKCJ01000176; RSL53040.1; -; Genomic_DNA.
DR STRING; 1325737.A0A428PJ44; -.
DR Proteomes; UP000287544; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000287544};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 7..374
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 1013..1185
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1199..1509
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 111..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1366..1403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..592
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..613
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..643
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..800
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1366..1386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1520 AA; 165497 MW; F92E99473A8FFAB9 CRC64;
METGEYETNT LSINNIASIA FRIYEPSPDQ SQSFQSSALE IESILRDQGR LVSYDANRFG
IWIFQIVSKD GATDAVSPVP GATLEVCGHT LGMVEEGTLE PMALQKSRIP GNTTQNAAAN
PPSANPATDL SQRNSMLSPT QAMGGTLQEG DLQVSSQPTE TKATQPVPKI IYENFIVAIL
FSVSFAFCSR SMAVPLNYRT VLIPPSLGDA SEQERGSLPS DPVIGTFKTY LTTTGSLIIS
LYFSYCRSLA SVEDAVSTDP ISPSSPILAA PYGVLATKQS LSNGDHVSAV DHSLSQTPNT
QALAVRTVAD AQDSLWKHSC LRALQHCGLN PSNFKAGSWI NLLVSKPVSS EAENDPKRTR
ATVPWPGALC FRKKPLGVST TCRIGDTMLS GHEECHDPLG NARGWFNSTL EREEKVSKRK
AERVLAVPRE VNSGDAQPQR VNGQSPLTLR RPSTAAAGVM YPTPPDAIQQ HLGVTPSIDG
TISSPGNPPP TAAAVDIDTA MPTVTPMADA DNDGWDGNHE AKRDRSDSNL LGESENILSD
MGEDVFGDHN ITEDDFDFFD QPDGNDLDIT MGDLQPNPIP PPAQPLPPVV VKQPEPQKAI
EDHTIPKPKS EVDDSVFAKP ELKHARSSLN DELNHRAKPE RPTSTKRGSS PFDPATVFKR
VRASLSSPVQ DSRNPSPIAR RKSSIFEKVE FDPKLPLINK KYEQGGAFDF SRDQEAERLK
RDSNTLSDAE YLERHGKLKP TLKKLPLPAS TFIKGFTGMD VSNNTSPTRI NGNMSGSEDS
DLESDQGDSS SMSGGPTSPV KSSVKRVVID DDVLSQATST KEAEPGEETT EEQLAIELPR
LSKPESPELL LSRFFSEPEP LNVDVGLSNQ DYVEIAQIIT EQAATGRLEI GIDHKIDATT
GLATTRGHEV NVARTSLQLL HSVVPSSLGS ASPVRLKGLL DIPDLPLVGQ PNRLQPRSAP
GRDPNSEQMR PNNLYQIPVP HLEVRRSETK LSVLPSSVSF WESLGLAPSW GTKDISSLCI
FPGWKGMPDH VGTFLDRLKS VYESLKLGTF NKLVLSGEMK DGVLPYEVDR ISTSPDATVT
GHGSALVESM EVLRSSLSEW KSKHKNLVIY FVYSPDNPAS IIEACTAFYR CFDEYSDLLA
TRRETPQNEL VLQLVSSDLI SSTTSLVVPS PAEMIKLCME TYDRCTLFLD PEFGGPTPAP
AIMLEQPLPR IIDFKLGSTP SQSLMHENSC LHVGYAESLD GRWITAAWTD NRGQQQATAS
YSVTRTRTPD RSTAQQKAAI LVEIWATTLA MMSIWKVHWR VIVTKSGPID QREVEWWQTA
SKLDDKASFT MVLMTVDTSP SLQLIPPTVK IPHTATSAFY STPVSTPQAS IVSPEQTTTP
ATPMRDNNPP GATPGAESAG EADGDSFLID ATDQTWGAVV GHRLGNSTTL LEVRPALVSG
YLIKRTGTRI EDPPVVMEVN LVHTEATPRA YEPLLREMLC YFRGLGTLAR ARGVVDRETD
VRPWHIAAAE KGVRALHLLL
//
