ID A0A428R0C9_9HYPO Unreviewed; 1143 AA.
AC A0A428R0C9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE AltName: Full=Mitochondrial DNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00031966};
GN ORFNames=CEP54_001493 {ECO:0000313|EMBL:RSL71094.1};
OS Fusarium duplospermum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium solani species complex.
OX NCBI_TaxID=1325734 {ECO:0000313|EMBL:RSL71094.1, ECO:0000313|Proteomes:UP000288168};
RN [1] {ECO:0000313|EMBL:RSL71094.1, ECO:0000313|Proteomes:UP000288168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL62584 {ECO:0000313|EMBL:RSL71094.1,
RC ECO:0000313|Proteomes:UP000288168};
RA Stajich J.E., Carrillo J., Kijimoto T., Eskalen A., O'Donnell K.,
RA Kasson M.;
RT "Comparative genomic analysis of Ambrosia Fusariam Clade fungi.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSL71094.1}.
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DR EMBL; NKCI01000007; RSL71094.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A428R0C9; -.
DR STRING; 1325734.A0A428R0C9; -.
DR Proteomes; UP000288168; Unassembled WGS sequence.
DR GO; GO:0005760; C:gamma DNA polymerase complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006264; P:mitochondrial DNA replication; IEA:InterPro.
DR CDD; cd08641; DNA_pol_gammaA; 1.
DR Gene3D; 3.30.420.390; -; 2.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR002297; DNA-dir_DNA_pol_A_mt.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR041336; DNApol_Exo.
DR InterPro; IPR047580; POLG_palm_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR PANTHER; PTHR10267; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10267:SF0; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF18136; DNApol_Exo; 1.
DR PRINTS; PR00867; DNAPOLG.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000288168};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 700..930
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 281..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1117..1143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1143 AA; 129314 MW; B985715DE1AC7D19 CRC64;
MMFTTAAGRP LHGSTASFIR ITRHQAFRRH AWRAHVRWLA AVAEQKKPTS LALPSEARYN
EIGVQQLSSH VFDQIFLNGT KPPPPELVKL SEDHLRRHEL LGKNTDKSDP IAFDLPPLQG
DDLDHHFYKL GLDCAEPFLS IAKEFALAIP PPKPRQWVRE SGWIKYHPNG ETEKVDAPPE
TVLCFDTEVM WKESPFAVMA CASSPTAWYA WLSPWLLGET ENERQLIPLG DPTKERVIIG
HNIGYDRARI FEEYNIKQTR NAFLDTMSLH AAVNGMCSQQ RPTWMKHKKN REQRERTASQ
TPGHDLAELL SNQGMHDEEE LWVERSSINS LRDVAKFHLN VSIDKAVRDD FGELDREGIL
EKLDELMDYC AADVSITHRV YSIVFPNFLR VCPHPVSFAA LRHLSSAILP VNKSWDAYIA
NAEATYQKLS DAVQERLVGL TEKALEIKND DDKWKNDPWM QQLDWSGQEI KMVKGKRKND
PPRPAARQKK PGMPKWYKDL FQKNDAPINI TVRTRIAPLL LKLSWDGHPL FWSDKYGWTF
RVPRQEAANY TAKSMVKCVF DEAEALLRDD HAHTYFKLPH KDGPNARCTN PMAKGYLAYF
ENGTLSSEYP YAKEALEMNA SCSYWISARD RIRSQMVVYN EDLTNGQPSL ENEPNSASET
SATKTDGFIL PQIIPMGTIT RRAVENTWLT ASNAKKNRVG SELKAMVKAP KGYCFVGADV
DSEELWIASL VGDATFKLHG GNAVGFMTLE GTKSQGTDLH SRTASILGIT RNNAKVFNYG
RIYGAGLKFA ATLLRQFNPS LSERETTETA SKLYANTKGT KTNRKILYKR PFWRGGTESF
VFNKLEEFAE QERPRTPVLG AGITEALMSR YISKGGYLTS RINWAIQSSG VDYLHLLVVG
MDYLIRRFNI NARVAITVHD EIRYLVKEED KYRTALALQV ANVWTRAMFA QQVGIEDLPQ
SCAYFSAVDI DHVLRKEVDM ECITPSHQTP IPPGESIDIT TLLEKGEAAR LDPAIVPDVS
YAPKLDDIEY TPRVPVMQAI REATEGSLPF LKAQIVQTDE ELRDIVKGVR AVELAAAKKD
RPMTKSQLKG VLPYRAYPKL VPMNEPMSVS EAMGTKHQNN YHGQKKGWLH PNSNKGARSN
WGL
//
