ID   A0A428WRF6_9ACTN        Unreviewed;       742 AA.
AC   A0A428WRF6;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   RecName: Full=Membrane transport protein MMPL domain-containing protein {ECO:0000259|Pfam:PF03176};
GN   ORFNames=DMB66_50755 {ECO:0000313|EMBL:RSM45666.1};
OS   Actinoplanes sp. ATCC 53533.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=1288362 {ECO:0000313|EMBL:RSM45666.1, ECO:0000313|Proteomes:UP000287606};
RN   [1] {ECO:0000313|EMBL:RSM45666.1, ECO:0000313|Proteomes:UP000287606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 53533 {ECO:0000313|EMBL:RSM45666.1,
RC   ECO:0000313|Proteomes:UP000287606};
RA   Waglechner N., Wright G.D.;
RT   "Evolution of GPA BGCs.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RSM45666.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; QHHV01000236; RSM45666.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A428WRF6; -.
DR   OrthoDB; 7051771at2; -.
DR   Proteomes; UP000287606; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000287606};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        179..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        214..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        243..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        292..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        319..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        535..554
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        566..587
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        599..623
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        650..669
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        675..695
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          46..382
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          480..709
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
SQ   SEQUENCE   742 AA;  76658 MW;  A7B5B0A3CB669CF9 CRC64;
     MLSRTLVRLG TSAARRPWRV IAAWLLVATI AVAAAVAFGG KTADSMTAPG LDSQRAAELL
     ERAGTGQEGM TAQVVVTPIN GGDTFLADGA ARTGLQRLQA EIRALPHVLS TSDPAGALDR
     GRDAAAAGGP ISADGRIAVI RVQYPEQSQL STADLDALVD LGDRLRGELP LRIEMGGDLF
     FAFSSPAAGV GELVGILAAA AILFLAFGSF TAAALPIGMA LFGLTVGVST MTVLAAATEI
     PTFAPVLGSM VGLGVGIDYA LFVLARHREY LGRGIEPHEA AGRAVATAGR PVIFAGVTVV
     VSILGMAAAN VPFMTMGGIA VSIVVTVMVV ASVTLLPAFL GVAGARLARV SRFARRRTPA
     ARAVPVGGWQ RWIGHVNRHP VPYALGAAGL LMLAALPVLG LRVGLPDDGS LPASRTERRA
     YDLVAEGFGP GTNGPLVIAV DSAGDPGVVD RLAAAVAADP GIASVAPAQV DRATGIASLV
     VFPTTGPQQR ATADTVTRLR ADVLPGAVGP GQASAHVGGA AASLSDVGKR TSERLPLFIA
     AVLALSFLLL MLVFRSVLVP LKAVLLNMLS IGATYGIMVA VFQWGWGATL IGLESTVPIV
     SFIPMFLFAI LFGLSMDYEV FLLSRVREEY LRSGDNATAI VRGIASSARV ITSAALIMVA
     VFLSFAIAND PSTKMFGFGL ATAIFVDATV VRMVLVPATM TLLGRANWWL PSWLDRVLPR
     GPEDIDADDV DAEAGRVLAA AR
//