ID   A0A428X1W4_9ACTN        Unreviewed;       297 AA.
AC   A0A428X1W4;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   13-SEP-2023, entry version 14.
DE   SubName: Full=Fructose-bisphosphate aldolase {ECO:0000313|EMBL:RSM49331.1};
GN   ORFNames=DMB66_45005 {ECO:0000313|EMBL:RSM49331.1};
OS   Actinoplanes sp. ATCC 53533.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=1288362 {ECO:0000313|EMBL:RSM49331.1, ECO:0000313|Proteomes:UP000287606};
RN   [1] {ECO:0000313|EMBL:RSM49331.1, ECO:0000313|Proteomes:UP000287606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 53533 {ECO:0000313|EMBL:RSM49331.1,
RC   ECO:0000313|Proteomes:UP000287606};
RA   Waglechner N., Wright G.D.;
RT   "Evolution of GPA BGCs.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RSM49331.1}.
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DR   EMBL; QHHV01000185; RSM49331.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A428X1W4; -.
DR   OrthoDB; 9771504at2; -.
DR   Proteomes; UP000287606; Unassembled WGS sequence.
DR   GO; GO:0004332; F:fructose-bisphosphate aldolase activity; IEA:InterPro.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   InterPro; IPR041720; FbaB-like.
DR   PANTHER; PTHR47916:SF1; 3-HYDROXY-5-PHOSPHONOOXYPENTANE-2,4-DIONE THIOLASE-RELATED; 1.
DR   PANTHER; PTHR47916; FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 1; 1.
DR   Pfam; PF01791; DeoC; 1.
DR   PIRSF; PIRSF038992; Aldolase_Ia; 1.
DR   SMART; SM01133; DeoC; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000287606}.
FT   ACT_SITE        166
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038992-1"
FT   ACT_SITE        200
FT                   /note="Schiff-base intermediate with dihydroxyacetone-P"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR038992-1"
SQ   SEQUENCE   297 AA;  32506 MW;  CF657882E49497E6 CRC64;
     MTARLRLSQC GLSAGKKARL HRILYQHGLG NGTALFLPYD QGLEHGPRDF FADPIAADPK
     YIVRLALEGG FNGIAIQIGL AEKFYWDYAG EVPLILKLNG KTDIPADTRA LSPLHASVED
     AVRLGADAVG YTLYVGSPAQ DADFAQYRVV RQDAQRLGMP LIVWAYPRGE AIEHKGGKDS
     FYAVHYAART ASELGADVVK VNFPHPEKHT DVPAPYEADY SSQQAIDAVV RAANRTLVLV
     SGGSRAGDDV MIEKAQESMS AGATGLIFGR NVWQRDHDES LRFVDRLREI LAKYPTP
//