ID   A0A428XMH9_9ACTN        Unreviewed;       782 AA.
AC   A0A428XMH9;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Hyaluronidase {ECO:0000313|EMBL:RSM56531.1};
GN   ORFNames=DMB66_34290 {ECO:0000313|EMBL:RSM56531.1};
OS   Actinoplanes sp. ATCC 53533.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=1288362 {ECO:0000313|EMBL:RSM56531.1, ECO:0000313|Proteomes:UP000287606};
RN   [1] {ECO:0000313|EMBL:RSM56531.1, ECO:0000313|Proteomes:UP000287606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 53533 {ECO:0000313|EMBL:RSM56531.1,
RC   ECO:0000313|Proteomes:UP000287606};
RA   Waglechner N., Wright G.D.;
RT   "Evolution of GPA BGCs.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RSM56531.1}.
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DR   EMBL; QHHV01000119; RSM56531.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A428XMH9; -.
DR   OrthoDB; 9760892at2; -.
DR   Proteomes; UP000287606; Unassembled WGS sequence.
DR   GO; GO:0016231; F:beta-N-acetylglucosaminidase activity; IEA:UniProt.
DR   GO; GO:0042806; F:fucose binding; IEA:UniProt.
DR   GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:UniProt.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR   GO; GO:1901564; P:organonitrogen compound metabolic process; IEA:UniProt.
DR   GO; GO:0010185; P:regulation of cellular defense response; IEA:UniProt.
DR   GO; GO:0001868; P:regulation of complement activation, lectin pathway; IEA:UniProt.
DR   Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 1.20.58.460; Hyaluronidase post-catalytic domain-like; 1.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR006585; FTP1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR029018; Hex-like_dom2.
DR   InterPro; IPR015882; HEX_bac_N.
DR   InterPro; IPR011496; O-GlcNAcase_cat.
DR   PANTHER; PTHR13170; O-GLCNACASE; 1.
DR   PANTHER; PTHR13170:SF16; PROTEIN O-GLCNACASE; 1.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF02838; Glyco_hydro_20b; 1.
DR   Pfam; PF07555; NAGidase; 1.
DR   SMART; SM00607; FTP; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
PE   4: Predicted;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000287606};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..782
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5019365595"
FT   DOMAIN          621..773
FT                   /note="F5/8 type C"
FT                   /evidence="ECO:0000259|PROSITE:PS50022"
SQ   SEQUENCE   782 AA;  83807 MW;  4B29D30F75BDA696 CRC64;
     MLRPTRFLPI LATTLLASAG ATGPAAAAPA TALPVVSPTP QRIERIGPDV AVPDRVELIA
     TDATDRAAAD LLGTVLRRLG ADHVVRRSRP SNRAGLTVYL GPAARPDISA LLAGTAVPQQ
     AEGYTVRVER RQVVLGGADP AGQYYAVQTL RQLALPRRIA GASVSDYPAM PRRGTIEGFY
     GSPWTPAERL DQLAFYGDIK ANTYIYAPKD DPYHRDRWRE PYPADKLAEL RQLVDAATAH
     HVRFTFALSP GASICYSSAA DRQALTAKLQ AVYDLGVRDF SIPLDDISYG RWNCVDDRTA
     YGAPGPGAAA RAQVDLLNDV QRGFVAGHPE TRPLQMVPTE YGDLTDTAYK QVIRATLDPG
     VLVMWTGTDV VPPSITVAQA SRASELFGRD VFVWDNYPVN DYAQAAGRLL LAPYDKREAG
     LSDHLAGIVA NPMNQAAASK VAVFTMADFA WNDRAYQPAA SWQRAASYLA GGDPAGTRAL
     LVFFDLNHLA PTFGAQPWQP QAPALAALLA AESPELRAYV RGIIAAPATI RGTVRDAGFL
     ADTANWLDAT VLWGQAMDNG LDVRAAIRAG DAAAAAAARV RMTDLERRAR QIRSVPGENR
     VEGMVQIGDG VIDAFLDRVR AEHDAFLGLP PLVNVAQGKT ATQISDWSAD YAAGQSVNGD
     LSDFSTTSGA EPQPWWQVDL GATTEIETIE IYNRLDCCAE RVADYHVLVS AQPFPASLAE
     ALTAPGVVSV HETEQAGRPT TIDLPSSGRY VRVWLASAAP QELNMAEVRV LGHSPSSGVN
     PV
//