ID A0A428XMM8_9ACTN Unreviewed; 738 AA.
AC A0A428XMM8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 28-JUN-2023, entry version 15.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
DE Flags: Fragment;
GN ORFNames=DMB66_33910 {ECO:0000313|EMBL:RSM56565.1};
OS Actinoplanes sp. ATCC 53533.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1288362 {ECO:0000313|EMBL:RSM56565.1, ECO:0000313|Proteomes:UP000287606};
RN [1] {ECO:0000313|EMBL:RSM56565.1, ECO:0000313|Proteomes:UP000287606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53533 {ECO:0000313|EMBL:RSM56565.1,
RC ECO:0000313|Proteomes:UP000287606};
RA Waglechner N., Wright G.D.;
RT "Evolution of GPA BGCs.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSM56565.1}.
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DR EMBL; QHHV01000117; RSM56565.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A428XMM8; -.
DR OrthoDB; 9810730at2; -.
DR Proteomes; UP000287606; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.1530; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR45339; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR PANTHER; PTHR45339:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF18947; HAMP_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:RSM56565.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000287606};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 22..74
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 318..551
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 607..724
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT COILED 48..75
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 239..308
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 657
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:RSM56565.1"
SQ SEQUENCE 738 AA; 79890 MW; DF38C41BD93808D7 CRC64;
AEVKGVSGTW RDLTDNVNQL ASTLTTQLRA IAEVSTSVTR GDLTQSVAVE AQGEVAELKD
NINQMIVTLR ETTKANAEQG WLDSNLARIG GLLQGQRDLG EVCRMIMTEV TPLVDAQLGA
FFMVDHEEAV MRLRLAASYG YVARNHEVTF GPGEALVGQA AVSRRTIRVR AAHDGALTMR
SGLMSMPPSD LVVLPVLFEG EMLGVIEFAS VAAFSGLHLT FLERLVAAIG VALNTIQANR
RTEELLAQSQ RLAREMQDQS AELQRTNAEL EDKAQLLSEQ KGNIETKNRE IELARLGLEE
KAQQLSRASA YKTEFLANMS HELRTPLNSL LLLARLLADN SEHNLTEKQI EFARTIHSAG
SDLLSLIDDI LDLSKIEAGR MDVEPDQVDF DGVRSYVEQA FTPQADEKGL EFRVEVSDDL
PESIVTDAQR LQQILRNLLS NAVKFTDNGS VTLRIHPAPP EADFGIPALA AARQVVAFAV
SDTGIGISDE KLSLIFEAFQ QADGTTSRKY GGTGLGLSIS REFAALLGGT ILVSSSPGAG
STFTLYMPDA LVGDAIPVPS MPQLPASHSA GEPRRALSSL DLPLITARPE LETHTVSPAS
RQLDGATVLI VDDDVRNVFA LTSALEMHGL NVLYSDNGVD GVRLLAEHPE VDIVLMDAMM
PEQDGYETTR GIRRNQRFAD LPVVFLTAKA MPGDRESALA AGASDYITKP VDLDELIELM
ARWVNASDNS GTESQNGG
//
