ID A0A428XXQ9_9ACTN Unreviewed; 376 AA.
AC A0A428XXQ9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Acetyl-CoA C-acetyltransferase {ECO:0000313|EMBL:RSM60129.1};
GN ORFNames=DMB66_25580 {ECO:0000313|EMBL:RSM60129.1};
OS Actinoplanes sp. ATCC 53533.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1288362 {ECO:0000313|EMBL:RSM60129.1, ECO:0000313|Proteomes:UP000287606};
RN [1] {ECO:0000313|EMBL:RSM60129.1, ECO:0000313|Proteomes:UP000287606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53533 {ECO:0000313|EMBL:RSM60129.1,
RC ECO:0000313|Proteomes:UP000287606};
RA Waglechner N., Wright G.D.;
RT "Evolution of GPA BGCs.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSM60129.1}.
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DR EMBL; QHHV01000078; RSM60129.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A428XXQ9; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000287606; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000287606};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:RSM60129.1}.
FT DOMAIN 5..245
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 254..375
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 88
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 332
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 362
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 376 AA; 39021 MW; 6BFD7A204BF35A59 CRC64;
MEAFLIGAVR TPVGRRGGAL SAVHPADLGG HAIAALLERT GADPAMVDDV ILGCVDTLGP
QSGDIARTCW LAAGLPEHVP GVTVDRQCGS AQQAVHFAAQ AVLSGTADLV VAGGVQSMSQ
VPIGSAMAPR GPYEGSAGWA ARYGDQEISQ FRSADEIAAK WGLSRAEIEQ FALDSHRRAV
HAIDEGRFRA EIAPWGDCDT DECPRRDTSA ARMAALAPLR QGGVTTAAAA SQLADGAAAL
LVASARAVRD QGLRPRARIL HLSARGDDPV LMLTAPIAAT AHALRRSGLR LADIDLFEVN
EAFASVVLAW LRETGADPAR VNVNGGAIAL GHPLGATGAR LLTSLLHELE RTGGRFGLLT
MCEGGGQANV TIIERL
//
