ID A0A428Y288_9ACTN Unreviewed; 1816 AA.
AC A0A428Y288;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:RSM61648.1};
GN ORFNames=DMB66_24340 {ECO:0000313|EMBL:RSM61648.1};
OS Actinoplanes sp. ATCC 53533.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1288362 {ECO:0000313|EMBL:RSM61648.1, ECO:0000313|Proteomes:UP000287606};
RN [1] {ECO:0000313|EMBL:RSM61648.1, ECO:0000313|Proteomes:UP000287606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53533 {ECO:0000313|EMBL:RSM61648.1,
RC ECO:0000313|Proteomes:UP000287606};
RA Waglechner N., Wright G.D.;
RT "Evolution of GPA BGCs.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSM61648.1}.
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DR EMBL; QHHV01000072; RSM61648.1; -; Genomic_DNA.
DR OrthoDB; 5521237at2; -.
DR Proteomes; UP000287606; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 3.30.450.40; -; 2.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR45138:SF9; DIGUANYLATE CYCLASE DGCM-RELATED; 1.
DR PANTHER; PTHR45138; REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00065; GAF; 2.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF55781; GAF domain-like; 2.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000287606}.
FT DOMAIN 19..271
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1685..1816
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT REGION 406..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..430
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 46
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1816 AA; 190641 MW; 2714781858DECE34 CRC64;
MTYVAANSTP SGAPRVPGVT VLDELGRGAN AVTYRVRRDG RDWAMKVYAR TPGGGRPALL
VLRREAALLT WVDHPGLPRV HEVGEVDGRA YMIMDLVAGR PLGDVLAAGP LSVEAVVRLG
RAVAEALAAV HRIGLVHRDV KPPNIMIEPG GHARLIDFGM AVRTDRETGD AAAGTFRYAA
PEQTGMIKRR VDGRADLYAL GAVLFECLAG TPPFVADDAG ELLRMHAATP APALAEHRPD
APAELCAIVA TLLAKDPDDR YQSVPLLLAA LGAVDGAPAG DDDTEAGRLP LAGRDPQWQA
LREAWQQVRS GAGGTVLVTG GPGAGKTRIA EELVTRALAD GVPVLHARCA AGAAPLAALR
EAVEYHALHP AEPDRAARAD QLRAVAVATG TATAVGRLSP LLAGPTAPGP AAAGPTAPGP
AAPGPAAPGP TAAGPTASDR ATQDPTTAGL AASDRAAPGL AASDRAAAGP AGWDEPAWPD
ALGQGIAGFL AGLARDAGGA LLCLDDVDAA DAASLTVLRQ LVGQLDACPL LVLGTATGDG
SAPAPVRAVF GDSQAVTLGP LDPAAVAALV TACVRGLPAD DELVQRLVAR GGVSPFEVVE
YVRAVVDAGL LAPAWGSWAL DTEGLDDVPL LGDVYELMLS RLDGLAPATR RLLTVAAAIG
PAFAPDLAAR ANRMAAAAVD AAPEPTADEA LAEALDEALD EALACRVVEH RGDRLAFVHD
GIRTALLAGL DDDRRRALHQ SLAEALDQEP SDDPEHVHAL ARHYLLGEVE RTPDRLAVAC
LAAGRLALAS HAPAEAVECL AAVERLAGRE AWLVAHEVDE LLGAAYYQAG HLGDAQRVLS
RALAGVPTRL DRARLLSRIA EIQQAMGDIA ASLATARRAL AELGRPLPAN PLMLVVSTLL
SFVAGLCVER FRIGFGTAAP RRRAGYRLRT RLYNTSAVSA ILMMDPLNTV MLTLRSLYPA
TRLGICAEYA RARIDMASLL RSTGLPWRRS AALARHAASM VGERGAVEHV AWLERSVPQV
LGQGDIRRLV ADTLDRAHLL DTSTYLKMLE GGLFLLLDAG YTDEAETLRA DGARRVAEDD
LAEHSVVVWG IAAAAARGNV AEADARWQQT EEHPPAFTNP GDLQTRLHAS IRLAVEQRDF
AELDRAAGEF AAMGMKPAVM PLYRRAIFAA IAYGRIEACL AAPPERRPAA LAAVDLAVRH
LRRGASGGRT LTAHHLVAAA YTRHLRGDHE GALAALAAAD HRLRAADAPQ VTYEAVRLRA
RALAALGRHE DAAAHAATAL AVAERQRWPH RARWIRTEFD LGGSQTGTIR DASSGSTGSF
SSDRQRLAAV EQLSLVASSI LDPAELTRVA LDEIIKLLGA DRAYLFLIDG TDHLVPHQGR
DAAGTDLTTP TGYGSTLVER VRHSREALVV TGTEEGIALG SQSVLAHGLR SILVAPLLFD
GRLLGVVYLD SRVAKGMFTA ADAGVLMTLT THVAAALETA RAAELAVAVR SARRERDIAE
TMRDAVTHLS GTLDPADVLR RLHATLRRAL PAGRSWLAVL DDGKLQVWDD HDEHHDAALA
GPDAEPDLAR LLTAAEPVTG AAGVAPPAPF GPAAGNPWVA IPLRLRAESV GLAVLTCPDP
AGYSAGQIEI GTALAGQGMT AYENARLFAQ VERLATTDGL TGLFNRRHFF ELALRELALS
RRRSGPLTVV MLDIDHFKQI NDRHGHPVGD QVIATVAQRL AATVRGTDVL GRYGGEEFAV
LLPDTGDDGS SILAERLRAV IGDRPIETDT GPLTVTVSVG VASRDTDMSV AELLGRADRA
LYQAKEGGRN RVVVSA
//
