ID   A0A429AVR1_9ACTN        Unreviewed;       830 AA.
AC   A0A429AVR1;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=DMB42_31695 {ECO:0000313|EMBL:RSN04394.1};
OS   Nonomuraea sp. WAC 01424.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=2203200 {ECO:0000313|EMBL:RSN04394.1, ECO:0000313|Proteomes:UP000286861};
RN   [1] {ECO:0000313|EMBL:RSN04394.1, ECO:0000313|Proteomes:UP000286861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WAC 01424 {ECO:0000313|EMBL:RSN04394.1,
RC   ECO:0000313|Proteomes:UP000286861};
RA   Waglechner N., Wright G.D.;
RT   "Evolution of GPA BGCs.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RSN04394.1}.
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DR   EMBL; QHHZ01000012; RSN04394.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A429AVR1; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000286861; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 2.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:RSN04394.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286861};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          20..473
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          811..830
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   830 AA;  89602 MW;  7DA1D3981B0326EA CRC64;
     MARRTTAPPP EDFEERIVDI DVSSEMRKSY LEYAYSVIYQ RALPDARDGL KPVQRRILYS
     MSEMGLRPER GHVKSSRVVG DVMGKLHPHG DSAIYDALVR LAQPFSMRLP LVDGHGNFGS
     PDDLPAAMRY TEARLAPAAM LMVESLDEDT VNFKPNYDGQ ETEPTVMPSA FPNLLVNGTT
     GIAVGMATNM APHNLAEVVA AARHLIKKPD ATLDELMKFV PGPDLPTGGS IIGLQGVRDA
     YETGRGTFRM RARCAVEQIT PRRKGIIVTE LPYNVGPERV VTKIKELVTS KKLQGIADLK
     DLTDRHKGLR LVIEIKNGFI PEAVLEELYR LTPMEETFGI NNVALVDGEP RTLGLRELLQ
     VYVDHRLEVV RRRSEFRRRK REERLHLVDG LIIALLNIDE VIQVIRSSDD SAQARARLME
     VFDLTDIQAA YILDTPLRRL TRFDKLELDS EKETLSEEIA ALTEILSSEA KLRQVVSGEL
     AEVSKKYATP RRTVLLEAPG VARTPVVSLQ VADDPCWALL SSTGLLARTS NAEALPGEGE
     RSAHDVLVSV ARTSVRGEVG VVTSLGRLIR VQVVDLPTLP PSANPPTLSG GHPVSEYVSL
     QPDEKVVGLG SLDPDSPGLA LGTAQGVVKR VVPDYPANRD DFEVITLKDG DTVVGAAELD
     SEDHDLVFVS SDAQLLRFPA SLVRPQGRPA GGMAGIRLDD GARVIWFGVV DPSLPAQVVT
     VAGSSTALPG TQVGGGKVSD YAEFPAKGRA TGGVRAQRFL KGEDELLLAW AGPAPAKAVS
     AVGKPVPLPE EIGRRDGSGV RLTHTIGAVG GALASGPAAG VAPPPPAEEE
//