ID A0A429AX36_9ACTN Unreviewed; 3214 AA.
AC A0A429AX36;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:RSN04857.1};
GN ORFNames=DMB42_29105 {ECO:0000313|EMBL:RSN04857.1};
OS Nonomuraea sp. WAC 01424.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Nonomuraea.
OX NCBI_TaxID=2203200 {ECO:0000313|EMBL:RSN04857.1, ECO:0000313|Proteomes:UP000286861};
RN [1] {ECO:0000313|EMBL:RSN04857.1, ECO:0000313|Proteomes:UP000286861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WAC 01424 {ECO:0000313|EMBL:RSN04857.1,
RC ECO:0000313|Proteomes:UP000286861};
RA Waglechner N., Wright G.D.;
RT "Evolution of GPA BGCs.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSN04857.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; QHHZ01000011; RSN04857.1; -; Genomic_DNA.
DR OrthoDB; 3671989at2; -.
DR Proteomes; UP000286861; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR CDD; cd19543; DCL_NRPS; 1.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000286861}.
FT DOMAIN 531..606
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1609..1683
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3128..3203
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 440..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1091..1118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3110..3129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..641
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3214 AA; 342349 MW; C6EA77B4968AC534 CRC64;
MDNSTRDVLD LFAERVRLAP GATAVSSAAG SLAYRELDTR ANGFAHRLRG LGAGPDTLVA
VYAERGLDLV VALLGVLKAG AAYLPLDPGV PASRLAVVID DAGAPVVVTQ RALRERLPVT
AARVVCVDDD PAPFADAPPA SPGRPADLAY AIYTSGSTGR PKGVLVERRQ LAAYLACCLR
DYPGLAGTAL LHSSISFDLS VTTLWGPLVA GGRVHAGTLD EPGGVRPSFL KITPSHLPLL
EDGSPDASPE RGELVIGGEA LHGDAIGRWR ADRPGVTVVN EYGPTETTVG CVAFRLEPGD
GTPGGAVPIG RPMSGSRAYV LDARLRPVPP GERGELYVAG AGVARGYRGR PGGTAERFVA
DPYGTDGERM YRTGDVVRLL PDGELEYLGR ADDQVKLGGH RIEPGEIEAA LTRHPRVAAA
AVVADGDRLV AHIVPITRPI TRPIPQPATT SEAPTAVPAE APSGAPGGAS LEGAAGPSPE
QLRAFLARDL PEYMIPSVFQ PLDRLPLAAS GKVDRAALPA TGPQGATGYT PPGDHKERVI
AELWAEVLGL DRVGVTDDFF AIGGNSLLAF RVVPRIRAAL GTSLSPRAIF RERTVAALAA
SLKPDENHAE NGDENHAGNR DGVRDGVRNE GRAESRDEAG DAGTDVVTPL PPGHDAPLSY
AQRRFWFFHA HDPGGTEYNV RFGYRLNGPF DPEALRTALG ELIARHEPLR TTIEDGGADP
TRAEPVQKVH ADVEVPLTVT DVAGLPGEEL DRMLRHEVTR PFDLAHGPVL RLAVLRLAAE
EHLLVLSLHH SVIDAVSMRV LADELGLLYD AARHGHRATL APLPVRYADY AAWQRDRWTD
DSLADQLDHW RRRLDGITPL DLPADRPRPA VRSSAGAAHR FTVPAELASA LGDLAARTGA
TPFMVLVAAC QVLLSRYAGQ RDVSVGTPVS GRDLPELEPL IGCFINTLVL RSTVDERATF
AEFLGAVRET VLNAFANRDV PFDRLVRELD AERDPSRTPL VQAMVALQNA PPKTPRFAGA
RTEPYGLPHV SSIFDVTLEF VEREDGGALD AMIEYSTDLF EAATAERMAA HLIALLEAVT
ATPDRPLARL PLPPTPRTAP VLTGPAVPAA GRGGGRAGRP VHVQVSEWAR VAPDAVALEW
DGGTRTYADL DRRADRLAHR LRGLGVGRGV PVVVCMERGP DMVTAALGVL KAGGAYVPLD
PGIPAERLAY VMADTGAPIL LADEDHEGLP VVHPGDMEAS DRAGAGPDCV AEPGDLAYII
YTSGSTGRPK GVMIEHRGLA DLCAWHVAAF GVVPRDRASQ VASLGFDAAV WEVWPYLCAG
ARVAFPGQDA LDDPDELVAW FTAMGTTICF LPTPRLETVL DLPAIDGTAL RTVLTGGDVL
RRRPRPGVPF RLVNNYGPTE ATVVATAGDV SREGEGLPPI GRPLTGSAGY VLDAYANPVP
EGVPGELYLA GPGLARGYLN RPGLTAERFV ADPFGPPGGR MYRTGDLVRR LPGGELEYLG
RSDDQVKIRG FRVEPGEIEA ALQRHPSVGG AVVLASPGRD RLNGYVTPAG DAEPDAAALR
AFLAGSLPDH MIPAVIMVLP AFPLTERGKV DRAALPEPGA RAGTAAYVAP SGPVQRELAA
IWGEVLGVER VGAEDSFFTL GGDSILAIQV VSRAQRAGLR LTARDLFRRQ TVAALAPYVR
RAEQPANPAA EDAADGGPAP LTPIQRFLYD RFTVPGTFHQ YVEAELAADV DVRALGVAVS
ALVTRHAALR THFTRHDGER SQHVTPPPAG NVLRHVHLDD ETDEGDARGV IARESEAVQR
GIDAERGPVF AAVLFTGSGA PRLLLTAHHL VVDGVSWRVL LQDLHTAYGQ AVRGEPVDLG
AETASCVSWS RALAAHAAAG AFDGELPHWT RAARTSTGAT GATGATGALD VPLDREGANL
VASGRRTTVS LDEETTRALL RDVPGVYRTE VNEVLLAALA RTLGDWTGRT DLLLATEGHG
REEIFPGTDL SRTIGWFTTY FPLALRLPDG GDDGGGGWGE LLKSVKEQVR TVPGRGFGYG
VLRHLRGTAP DCHPGVCFNY LGRFDPPLGD LYRDVAPIGL FQDPGDVRPH LLDVVAAVRA
GRLEVTWEYS ADLHDEATVA RLADGFAANV TRLVRHCAEP GAGGRTPSDY PLAGLDQASL
DRLIADGRDV TDIADVYPLT PGQAGMLYEC LAAGDDLYVA QFGMLLDGVT DPGTLARAWQ
SVVDRTPVLR TSLVWEGLDH PVQIVHGRAS LPVVRHDWRR LPEDERRAAL AALLAADRAE
GLDLTAAPPS RLAVIRLDDD TVRVVWTLHH ILLDGWSVHR LLRDVLAAYA RLSGEGDGGA
PEPRRPFRDY VEWLAGRDLA ADETYWREAL AGLTAPTPLP YDRPPGREHR PKAAGRVRAA
LPPDLTRRLA DRAAAAGLTL NTLVQGAWSI LLSRHSGEPR VCFGATVSGR PEDLDGAESM
IGIFIQTLPV HVHVDGSRPL LPWLRELQES QAGAREHEAA SLTRIRAWSD VPPGTALFDN
IVVFENYPID YAAPGPRLRD VDAAEANGYP LGLVVYPGEE LSFVLLHDEE LFDAATVRRL
GEGLSALLGQ LAADPGGTVG SLSAVSARER RLTLTEWNDT ARDYPRRTVH ELFAERAREM
PGAVAVRGGG AELTYGELDR RAGELAGVLA GLGVRAESRV AVLQGRSPDA LVSMLAVLRA
GGAYVPLHPD FPAERMRWIL RDTGAVAVLT DRSLAGRAAD LGLPAVEVDG DLPVPDPAAR
PCSLPGSLAY VMYTSGSTGL PKGVAVTHED VVSLAWDHRW RGGGHDRVLF HSPHAFDAAT
YEMWVPLLAG GEVVVAPGDL DARRLRALAA EHGVTGMFLT AALFNLFAEE LPECFAGLRE
VWTGGEAASP QALARVIGRC PGTTFHNGYG PTETTTFVTT REMTPEIVRT GRAPIGRPMD
NTRAYVLDAA LAPVPVGAPR ELYLAGSGLA RGYLGRPALT AERFVADPFG GGGRLYRTGD
RVRWTPEGDL EFLGRVDGQV KIRGFRIETG EVEAALLAHP GVAEAVAMAR QDTAGRRTLA
AYVVPAAGGP APSHEELAAS LGARLPAYMV PAAFVSLDRL PLNANGKVDR AALPEPAPPR
EKAESYVAPR NPTEEALGRI WEQVLGLDRV GVHDDFFALG GDSITSLRVT SRVGPAFGVE
LSPRDIFLTP TVAGLSEVVQ DRILDSLEEA VHRS
//
