ID   A0A429B226_9ACTN        Unreviewed;       677 AA.
AC   A0A429B226;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 12.
DE   SubName: Full=MMPL family transporter {ECO:0000313|EMBL:RSN06614.1};
GN   ORFNames=DMB42_25405 {ECO:0000313|EMBL:RSN06614.1};
OS   Nonomuraea sp. WAC 01424.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=2203200 {ECO:0000313|EMBL:RSN06614.1, ECO:0000313|Proteomes:UP000286861};
RN   [1] {ECO:0000313|EMBL:RSN06614.1, ECO:0000313|Proteomes:UP000286861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WAC 01424 {ECO:0000313|EMBL:RSN06614.1,
RC   ECO:0000313|Proteomes:UP000286861};
RA   Waglechner N., Wright G.D.;
RT   "Evolution of GPA BGCs.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RSN06614.1}.
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DR   EMBL; QHHZ01000009; RSN06614.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A429B226; -.
DR   Proteomes; UP000286861; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286861};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        162..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        191..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        220..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        269..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        296..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        352..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        493..514
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        521..542
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        554..575
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        596..620
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        626..647
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          94..352
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          458..670
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
SQ   SEQUENCE   677 AA;  69913 MW;  C881DCCE90F0C2FE CRC64;
     MQPVARAGPM PPSGRGPYRR PMIRFCVRHR RLVGLMWLAL CAALVTAAAL APGPSHDDFS
     LPDSESGRAA ALLGPAAAEP KGAIVVSVPS GVQDAHVRRV TAALALPGVH TGPAALSGDG
     TVARVPLDYP DEDTGRRLKQ ARDGLRVPGA DVELSGGDFA DFAPGGLTEG VGLLAAAVIL
     LLALRSLIAA ALPLVVGVAG VTCGVALLTV LSNLVDTPAF AVYLTIMLGL GVGVDYALLI
     VTRHRAALQE HGDVERAVTE AMRTAGRSVL FAGLIVIATG SGILFLGPAI GGGIALAAGC
     GVLMVMLASL TLLPALLALI GHRIDRFARG RRTTGGPRAA LRWSRVVRRR PGLTGALALV
     ALAVLALPAA DLRTGWSDAG NRPVTDTTRR AHDLLGRAFG PGWAGPLVLA VADPARIGAE
     EAAALAGRTP GVARAFATGE RSALVIPRTG PQDERTTDLL HRLRAALPAP VLVTGATAAA
     ADYAAFSAGR LPWTVGGVLL AAFVLLTVVF RSLVLPVKAI VVNLLSVAAA YGVVVAVFQW
     DVLGLGTGGP VDAWVPMMLF VVTFGLSMDY EVFLLSRVRE EYTRTADAGG AVAAGLARTA
     GVITAAASIM FCVFAAFGAF DDRALRIMGV GLAVAVLLDA TVVRLVLVPA VMEVLGERAW
     WFPVLTPRRL TSLRKNT
//