ID   A0A429BTH6_9ACTN        Unreviewed;       792 AA.
AC   A0A429BTH6;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 12.
DE   RecName: Full=Sarcosine dehydrogenase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=DMB42_02925 {ECO:0000313|EMBL:RSN15759.1};
OS   Nonomuraea sp. WAC 01424.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=2203200 {ECO:0000313|EMBL:RSN15759.1, ECO:0000313|Proteomes:UP000286861};
RN   [1] {ECO:0000313|EMBL:RSN15759.1, ECO:0000313|Proteomes:UP000286861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WAC 01424 {ECO:0000313|EMBL:RSN15759.1,
RC   ECO:0000313|Proteomes:UP000286861};
RA   Waglechner N., Wright G.D.;
RT   "Evolution of GPA BGCs.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the GcvT family.
CC       {ECO:0000256|ARBA:ARBA00008609}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RSN15759.1}.
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DR   EMBL; QHHZ01000001; RSN15759.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A429BTH6; -.
DR   OrthoDB; 2055370at2; -.
DR   Proteomes; UP000286861; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR032503; FAO_M.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   PANTHER; PTHR13847:SF193; PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR13847; SARCOSINE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16350; FAO_M; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF103025; Folate-binding domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000286861}.
FT   DOMAIN          6..359
FT                   /note="FAD dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF01266"
FT   DOMAIN          362..417
FT                   /note="FAD dependent oxidoreductase central"
FT                   /evidence="ECO:0000259|Pfam:PF16350"
FT   DOMAIN          420..689
FT                   /note="Aminomethyltransferase folate-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01571"
FT   DOMAIN          709..784
FT                   /note="Glycine cleavage T-protein C-terminal barrel"
FT                   /evidence="ECO:0000259|Pfam:PF08669"
SQ   SEQUENCE   792 AA;  86019 MW;  EC5D253C41222948 CRC64;
     MSDSARIVII GGGVGGASVA YHLTRLGERD VVLLERDELT SGSTFHSAGL VGQLRSDPTL
     TRMNQYSVEL YRTLDAGWTE CGGIKLASTP ERMAEIRRQI GWARTFGLPL EEISVAAAVE
     LFPLMDPAGV VGAAYLPTDG QIDPSMLCYA LATRAREGGV RVRTRTRVLG IDVERGRVTG
     VRTDQGNIAC EVVVNCGGMF AAEIGRMAGV RIPIVPMSHQ YVVTDACHDH PVLPTLLDPD
     LLVYYRQEVR GLVMGGYERT CAPWTASETS YDAVPAGFNG KLLPEDWPRF EEISANSRIR
     VPATADVGIR KLINGPEAFT PDNEFCLGET EVGGFFVAAG FCAHGIAGAG GIGKVMAEWI
     VEGEPGMDVH HMDIRRFGRR YRSPSYTVKR SVENYETYYD IRYPGHERAA GRPLRVSPAY
     SWHAAHGAVF GEKAGWERVN HYSAGPADED ERPRGWAGRL WSPAVGAEHR ATRTAAGLFD
     ESSFAKIEVT GPGAADLLEW VCDNRVARQV GAVTYTQALN RRGGIECDFT VTRRGEQEFL
     IVTGTASGSR DLAWLRRQAA LTGSAARIAD VTGQYACFAL WGPKARDILS GLTPDPLDFP
     FMSARELTVG DVPALALRVT FVGEVGWELY CSSEYGRALW ETLWRAGEPH GLAAGGYRAI
     DSLRLEKGYR VWGADIGPET TPYEAGLGFC VKPGKDFLGR DALDPDPARR LRCLVLSDPR
     AVALGNEPVR VDGQVVARVT SGGYGYTVKE SIAYAYLPVG PGAAVEVEVE GEWVPGVVVR
     EPRYEPAGSR VR
//