ID   A0A429FS25_9ACTN        Unreviewed;       507 AA.
AC   A0A429FS25;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=Acyl-CoA synthetase {ECO:0000313|EMBL:RSN64353.1};
GN   ORFNames=DMH08_17940 {ECO:0000313|EMBL:RSN64353.1};
OS   Actinomadura sp. WAC 06369.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Actinomadura.
OX   NCBI_TaxID=2203193 {ECO:0000313|EMBL:RSN64353.1, ECO:0000313|Proteomes:UP000288610};
RN   [1] {ECO:0000313|EMBL:RSN64353.1, ECO:0000313|Proteomes:UP000288610}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WAC 06369 {ECO:0000313|EMBL:RSN64353.1,
RC   ECO:0000313|Proteomes:UP000288610};
RA   Waglechner N., Wright G.D.;
RT   "Evolution of GPA BGCs.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RSN64353.1}.
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DR   EMBL; QHJN01000059; RSN64353.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A429FS25; -.
DR   Proteomes; UP000288610; Unassembled WGS sequence.
DR   GO; GO:0016877; F:ligase activity, forming carbon-sulfur bonds; IEA:UniProt.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR   PANTHER; PTHR43767:SF1; NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000288610}.
FT   DOMAIN          15..363
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          421..499
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   507 AA;  54343 MW;  BDAC0BD7C82F51C1 CRC64;
     MKHPWDRPLG VWYLAEHHPD APAVLHCPAG ETLTFAGLAA RAHRAVHALR ALGAGRGDVI
     GLALPNDLDI LVWQLAAAEA GWRYVTLNPR SPAPEVAAIA AHAGMKALIV HAAYADRAGA
     VDTVPVRVGV GGPIDGFVPQ EEALAGHPDS PPPDRAAGTP LVYTSGTTGT PKGIWRDLPD
     AAPEAAADLM KTFAHAFRFT PLEGAHLVSA GMFHGGCQSF YLAALHAGQP LVIMGSFDAE
     ETLRLVHEHR ITTGYMVPTQ FTRLLHLPSG VRDRYDVSSL ESIVHSAAPC PPEIKKRMLD
     WWGPVVWETY GGTEGAATIA KPHHWLAKPG TVGRPIRGMT VRILDDDGAE LPPGRVGAVY
     LDGGGRGFSY HRDPEQTAAV FRGTAFTLGD AGYLDEDGFL FIVDRIKDMI ITGGVNVYPA
     EVENALAAHP AVLDSAVVGV PDPEWGEQVR AFVQPAPGHE PSDALAADLI AHCRERLAGH
     KCPRAVEFRT ELPRTETGKL YKRLLRP
//