ID A0A429GBI3_9ACTN Unreviewed; 468 AA.
AC A0A429GBI3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=GntR family transcriptional regulator {ECO:0000313|EMBL:RSN71174.1};
GN ORFNames=DMH08_03325 {ECO:0000313|EMBL:RSN71174.1};
OS Actinomadura sp. WAC 06369.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Actinomadura.
OX NCBI_TaxID=2203193 {ECO:0000313|EMBL:RSN71174.1, ECO:0000313|Proteomes:UP000288610};
RN [1] {ECO:0000313|EMBL:RSN71174.1, ECO:0000313|Proteomes:UP000288610}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WAC 06369 {ECO:0000313|EMBL:RSN71174.1,
RC ECO:0000313|Proteomes:UP000288610};
RA Waglechner N., Wright G.D.;
RT "Evolution of GPA BGCs.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSN71174.1}.
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DR EMBL; QHJN01000007; RSN71174.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A429GBI3; -.
DR Proteomes; UP000288610; Unassembled WGS sequence.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000288610};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 11..79
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
SQ SEQUENCE 468 AA; 50452 MW; 2F023FA7E1C18A70 CRC64;
MDLHVSLVGR KDLSGQIYRQ LRDAILDGRL RAAEPVPPTR ELARRLAVSR NTVAVAYDRL
AAEGFLYSRV GAGTFVQEAG AAPRGAPAAS PPRPRRIWDG LEIWPRPMPG IRWDLRAGLP
DVRLFPFEAW RRITAGVLRP SGLRDAASAG DPAGLADLRE AIARHVGVSR SVRAGPADVL
VTSGTQQAID LIVRVLLEPG DVVAVEDPGY PPVVMLLRAA GLRVVGVPVD AEGLRVDGLP
GAARAVYVTP SHQFPLGMPM SLARRRALLD WARRRDAVVI EDDYDTEFRY GGRPIEPLQS
LDEDGRVLYT GTFSKVMRPV LRLGFLVAPP TLHRALRLAR YASSWHAELP AQAALARFID
EGLLARHVRR SRRAYQARHE RVAELAGRWS RPVPAEAGLH LSAPLPAGTD DAAVARRALD
AGIGLFALSE FAVTGPAAPG LVLGYGAADE AAIGAALARL ERIIAGRA
//
