ID   A0A429RV57_9ACTN        Unreviewed;       325 AA.
AC   A0A429RV57;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   28-JUN-2023, entry version 12.
DE   RecName: Full=UmuC domain-containing protein {ECO:0000259|PROSITE:PS50173};
GN   ORFNames=EF918_23930 {ECO:0000313|EMBL:RSS75577.1};
OS   Streptomyces sp. WAC06614.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2487416 {ECO:0000313|EMBL:RSS75577.1, ECO:0000313|Proteomes:UP000277644};
RN   [1] {ECO:0000313|EMBL:RSS75577.1, ECO:0000313|Proteomes:UP000277644}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WAC06614 {ECO:0000313|EMBL:RSS75577.1,
RC   ECO:0000313|Proteomes:UP000277644};
RA   Culp E., Yim G., Waglechner N., Wang W., Pawlowski A.C., Wright G.D.;
RT   "Unmasking the antibiotic production potential of Actinomycetes through
RT   CRISPR/Cas9 inactivate of ubiquitous gene clusters.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC       untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC       forks, which arise in vivo from mismatched or misaligned primer ends.
CC       These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC       exonuclease (proofreading) activity. May be involved in translesional
CC       synthesis, in conjunction with the beta clamp from PolIII.
CC       {ECO:0000256|ARBA:ARBA00025589}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC       {ECO:0000256|ARBA:ARBA00010945}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RSS75577.1}.
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DR   EMBL; RPRY01000202; RSS75577.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A429RV57; -.
DR   OrthoDB; 4317601at2; -.
DR   Proteomes; UP000277644; Unassembled WGS sequence.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0009432; P:SOS response; IEA:UniProt.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR   InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001126; UmuC.
DR   PANTHER; PTHR35369:SF2; BLR3025 PROTEIN; 1.
DR   PANTHER; PTHR35369; BLR3025 PROTEIN-RELATED; 1.
DR   Pfam; PF11799; IMS_C; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR   PROSITE; PS50173; UMUC; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000277644}.
FT   DOMAIN          17..119
FT                   /note="UmuC"
FT                   /evidence="ECO:0000259|PROSITE:PS50173"
SQ   SEQUENCE   325 AA;  34770 MW;  84E6554D3C377DE3 CRC64;
     MRRVDGEGVG GEEYAGVLGL LDGLTPVVQP LPPDSALADL HGALRHFHRT APELAALLRV
     RTLALFGVDC ALGLGPNPML ARLAAQDARY GQTVTVGQQP GAVRRFLERR PVTDLDGIGR
     KAARLLDAYG LDTVGRLAAA PPGTLRRILG VRPGREAHER AHGIDRTPVR PGAGARAVAG
     ERTFGRDELD PGRHRRALLS LTEELGARLR GQGQVCRSLT LTVRCADRTS VTRTRTFAEA
     TAHSAALTDA AYAMYAALGL QRARVRAVAL RAEELSGAER AHRQLSLDPE DDKARRLEAV
     TDQVRARFGP GAIARGTLAR GTWAA
//