ID   A0A429X421_9BACI        Unreviewed;       327 AA.
AC   A0A429X421;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   03-MAY-2023, entry version 10.
DE   SubName: Full=Thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha {ECO:0000313|EMBL:RST58145.1};
GN   ORFNames=D5F11_018760 {ECO:0000313|EMBL:RST58145.1};
OS   Siminovitchia terrae.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Siminovitchia.
OX   NCBI_TaxID=1914933 {ECO:0000313|EMBL:RST58145.1, ECO:0000313|Proteomes:UP000287296};
RN   [1] {ECO:0000313|EMBL:RST58145.1, ECO:0000313|Proteomes:UP000287296}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 29736 {ECO:0000313|EMBL:RST58145.1,
RC   ECO:0000313|Proteomes:UP000287296};
RA   Sun L., Chen Z.;
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RST58145.1}.
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DR   EMBL; QYTW02000023; RST58145.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A429X421; -.
DR   OrthoDB; 9766715at2; -.
DR   Proteomes; UP000287296; Unassembled WGS sequence.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          46..318
FT                   /note="Dehydrogenase E1 component"
FT                   /evidence="ECO:0000259|Pfam:PF00676"
SQ   SEQUENCE   327 AA;  35977 MW;  989F2F70A618A6B1 CRC64;
     MTVPLDKLKW MYEMMTKSRY YEDQMTEVYL EGKTPVFNIG AGTVPGEMHL STGQEPAAVI
     CAHLTKDDTV TSPHRPHHHA IAKGVDLKRM TAEIFGKETG LSKGKGGHMH LFDPDVKFSC
     SGIVGAGIPQ AAGAALAAKM KGKDWVAVTF LGEGAANSGA FHETLNMAAL WKLPLILVIE
     DNAYGISVSK KASTAIESND LRASAYGIEG AYVKNNDPIE MYKISEAAIK RARNGEGPSI
     IEIETFRYQG HFQGDPELYR EKEEVPSLKE RDPILRIRKL LIDDYGVNVS EVEEIESKVK
     AEVDEAYNFA RESELPKPEA ALADMFN
//