ID A0A430AI61_9ENTE Unreviewed; 696 AA.
AC A0A430AI61;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 13-SEP-2023, entry version 14.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=CBF30_00590 {ECO:0000313|EMBL:RSU07770.1};
OS Vagococcus entomophilus.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae; Vagococcus.
OX NCBI_TaxID=1160095 {ECO:0000313|EMBL:RSU07770.1, ECO:0000313|Proteomes:UP000288669};
RN [1] {ECO:0000313|EMBL:RSU07770.1, ECO:0000313|Proteomes:UP000288669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 24756 {ECO:0000313|EMBL:RSU07770.1,
RC ECO:0000313|Proteomes:UP000288669};
RA Gulvik C.A.;
RT "Vagococcus spp. assemblies.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSU07770.1}.
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DR EMBL; NGJZ01000001; RSU07770.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A430AI61; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000288669; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:RSU07770.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000288669};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 2..135
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 696 AA; 80125 MW; 4D9FF3FD2EE36B00 CRC64;
MKQLIIAEKP SVARDLAKVL GATKKTKSYI EGDNVIITWA LGHLLGLKMP EDYRKEWGEW
KMETLPMVPK KIGIKPLPKT GYQLKAISQL SKRKDVSEAV IATDAGREGE LVARWILEYT
RFNKPVKRLW ISSQTNKAIK EGFRQLKPSK LYDDLYESAL ARAEADWLVG LNVTRALTVK
YGDSLSAGRV QTPTLSMVRQ QEKKIEQFRP ENYFSVDFVY QHLLGRLQLK NPKQWKKREE
AEAYLKELAN EKAKVSDIHN KRKSEPAPLP YDLTEIQREA NQRYQFSAKR TLSLVQSLYE
THKIVTYPRT DSKYLTTDMK ATMKERLQAL APSYPQAKQY LKEGARVQVQ KVFQDACVTD
HHALIPTEQA PRFERLDNDE LKIYQMIVER FLGLFATPYV TNQQTITVTV GTAKFGFKQL
TVEEFGWKKV DPKKQEVKQI QFTNGEILPK HFEINKELTT PPKPLSESGL LGQMEKFNLG
TPATRAEIIE KLIKSELMER NTGSLSVTAK GKQLLELVNP SLISPDLTAK WENSLEEIAK
GKRKASGFIQ EIEADTKQLV QEIKRSEKKY QDFSVTSKKC PECGQNLKEK NTRDGKIYVC
INPECHYKRR KDPKISNHRC PQCHKKMEIH EGKNGAYFKC KFCMISEKVP DKKERKAKLN
KHEERKLLKK YSQEKVEPEE SPLALALKAA MNKEDE
//
