ID A0A430AZD3_9ENTE Unreviewed; 692 AA.
AC A0A430AZD3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 13-SEP-2023, entry version 15.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=CBF27_04375 {ECO:0000313|EMBL:RSU13418.1};
OS Vagococcus acidifermentans.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae; Vagococcus.
OX NCBI_TaxID=564710 {ECO:0000313|EMBL:RSU13418.1, ECO:0000313|Proteomes:UP000286773};
RN [1] {ECO:0000313|EMBL:RSU13418.1, ECO:0000313|Proteomes:UP000286773}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 24798 {ECO:0000313|EMBL:RSU13418.1,
RC ECO:0000313|Proteomes:UP000286773};
RA Gulvik C.A.;
RT "Vagococcus spp. assemblies.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSU13418.1}.
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DR EMBL; NGKC01000003; RSU13418.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A430AZD3; -.
DR OrthoDB; 9803554at2; -.
DR Proteomes; UP000286773; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR013498; Topo_IA_Znf.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR Pfam; PF01396; zf-C4_Topoisom; 2.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:RSU13418.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000286773};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 2..135
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT REGION 669..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 692 AA; 79347 MW; 2347AC7AA01257AF CRC64;
MKQLIIAEKP SVARDLAKVL GANKKTKTYI EGPNVIVTWA LGHLLGLKMP EDYKKEWAEW
QLATLPMIPK KHGIKPLPKT RHQLSAIAQL ARRSDVKEAV IATDAGREGE LVARWILAYV
KFDKPVKRLW ISSQTDKAIR EGFKQLKPSQ AYDNLYASAQ ARSEADWLVG LNVTRALTVK
YQDSLSAGRV QTPTLAMVRR QEEKIEHFKP ETYYTLDLLY QGLKGRLQLK QPRMYKEREQ
LAALIENFSA KQGVVTDIKE KEKRESAPLP YDLTEIQREA NQRYQFSAKK TLSVIQQLYE
VHKIVTYPRT DSKYLTSDMK QTMTERLQAL VAFDAERAKR YLKNGGKVVQ QKVFQDAKVT
DHHGLIPTEV APRVEKLDND ELRIYRMIVE RFFGLFAPVH VALKQTITVK VDDAEFLFRQ
EQIKEAGWKE SDDVAGKQVV FKKQQGIPLD FHINKELTTP PAPLSEGTLL AQMEKHNLGT
PATRAEIIEK LISSDLMERN NGKLSVSAKG RQLLKLVNPS LVSPELTEKW EKALEAIARG
QLDGRKFIRE IEEDTKQLVS EIKTSDKTYR DFSLTTKKCP ECGELLRERN TRDGKIYVCS
NPECTYRRRK EPKLSNHRCP TCKRKMQIIE GKNGAYFRCP HDGTTEKMLG KKARNQKISK
HEERRLMKKI NQESEPAESP LAAALRKAME EK
//
