ID A0A430BL07_9SPHN Unreviewed; 1081 AA.
AC A0A430BL07;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=Error-prone DNA polymerase {ECO:0000256|ARBA:ARBA00017273, ECO:0000256|HAMAP-Rule:MF_01902};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417, ECO:0000256|HAMAP-Rule:MF_01902};
GN Name=dnaE2 {ECO:0000256|HAMAP-Rule:MF_01902,
GN ECO:0000313|EMBL:RSU52319.1};
GN ORFNames=BRX43_05040 {ECO:0000313|EMBL:RSU52319.1};
OS Sphingomonas sp. S-NIH.Pt15_0812.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=1920129 {ECO:0000313|EMBL:RSU52319.1, ECO:0000313|Proteomes:UP000287772};
RN [1] {ECO:0000313|EMBL:RSU52319.1, ECO:0000313|Proteomes:UP000287772}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S-NIH.Pt15_0812 {ECO:0000313|EMBL:RSU52319.1,
RC ECO:0000313|Proteomes:UP000287772};
RA Johnson R.C., Deming C., Conlan S., Zellmer C., Michelin A., Lee-Lin S.-Q.,
RA Thomas P.J., Park M., Weingarten R.A., Less J., Dekker J.P., Frank K.M.,
RA Musser K.A., Mcquiston J.R., Henderson D.K., Lau A.F., Palmore T.N.,
RA Segre J.A.;
RT "Genomic and Epidemiologic Investigation to Identify Sphingomonas koreensis
RT Point Sources in an Indolent Hospital Outbreak.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC translesion synthesis (TLS). It is not the major replicative DNA
CC polymerase. {ECO:0000256|HAMAP-Rule:MF_01902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632, ECO:0000256|HAMAP-
CC Rule:MF_01902};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_01902}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC subfamily. {ECO:0000256|ARBA:ARBA00007391, ECO:0000256|HAMAP-
CC Rule:MF_01902}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSU52319.1}.
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DR EMBL; QLJH01000005; RSU52319.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A430BL07; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000287772; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd07434; PHP_PolIIIA_DnaE2; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR HAMAP; MF_01902; DNApol_error_prone; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR023073; DnaE2.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF4; ERROR-PRONE DNA POLYMERASE; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01902};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_01902};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_01902};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW Rule:MF_01902};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|HAMAP-Rule:MF_01902};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW Rule:MF_01902}; Reference proteome {ECO:0000313|Proteomes:UP000287772};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_01902}.
FT DOMAIN 8..75
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
FT REGION 1028..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1052
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1081 AA; 119784 MW; 281F262936EB7786 CRC64;
MASPTTYVEL QVTSHFSFLR GASSPDELFS AAALLGHRAL GIADLGSVAG LVRAWAAQKA
TGVRLIAGAR VVLDDGRALL LYPIDRPGWS RLTRLLSIGK ARAGKGGCTL GWADLPEWQE
GLIAILLPGD PGAAAARDLA DLRAVFGDRG YCGLTFRRRP NDAMRLHELA RQAGMAGVRA
VALGDVLYHA PEVRPLQDVV TAIREKRTID TLGYARERHA DRHLKSPGEM ERRFVAFPDA
IAATATIARA CTFDLGELSY QYPHERVMDG LTAQQALERM TGEAAERKFP DGVPEAYRRQ
IDHELRLIGE LGYAPYFLTV NSIVAESRRR GILCQGRGSA ANSCVCYLLG ITSIDPIKHE
LLFERFVSGE RREPPDIDVD FEHERREEII QWIYDSYGRT HAALTAVVTR YRARGAMREV
GKALGLPEDL TRALAGLVWG WSEEGVGEKQ VGQLGLNMDD RRLRLALDLA RRLIGTPRHL
SQHPGGFVLT HDRLDDLVPI EPAAMDKRQV IEWDKDDIDA LQFMKVDVLG LGMLGCMNRA
FTLLADAKDV HVGMADLQDD DPAVYAMIQK ADTLGTFQIE SRAQMAMLPR MKPAEFYDLV
IEVAIVRPGP IQGDMVHPYL RRREKIERPD YPRPELRAVL EKTLGVPLFQ EQAMKVAIVG
AGFTPAEADQ LRRAMATFKF TGGVHHFYEK LVGGMVANGY PRDFAERTFK QIEGFGSYGF
PESHAASFAK IAYASCWMKH HHPDVFCAAL LNAQPMGFYA PAQIVRDAQE HGVEIRPACI
NASRWDCTLE ATAGRYLAVR LGLRQVRGLA NVHGAAIVGA RGHLPFESVE DLWRRADIPR
AAIERLAEAD AFHRLGADRR QGLWKARGLD EAPLPLFAAA AGREPEVALR PLTEGREVVE
DYRALQLSLR AHPLAFLRDE LTRRGVTRAA DLAQLRDGRH VEVAGLILVR QKPGSAKGVL
FITIEDETGI ANGILWPDRF EAQRRTVMSA SMIGMKGRVQ REGQVIHVIC DRIVDHGDLL
AQVGRMDFRP RTGRGDGARH PGAPDRGDAG WRPGPRDSYW PSHATGMDPE QVVRIKSRDF
H
//