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Database: UniProt
Entry: A0A430BL07_9SPHN
LinkDB: A0A430BL07_9SPHN
Original site: A0A430BL07_9SPHN 
ID   A0A430BL07_9SPHN        Unreviewed;      1081 AA.
AC   A0A430BL07;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000256|ARBA:ARBA00017273, ECO:0000256|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417, ECO:0000256|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000256|HAMAP-Rule:MF_01902,
GN   ECO:0000313|EMBL:RSU52319.1};
GN   ORFNames=BRX43_05040 {ECO:0000313|EMBL:RSU52319.1};
OS   Sphingomonas sp. S-NIH.Pt15_0812.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingomonas.
OX   NCBI_TaxID=1920129 {ECO:0000313|EMBL:RSU52319.1, ECO:0000313|Proteomes:UP000287772};
RN   [1] {ECO:0000313|EMBL:RSU52319.1, ECO:0000313|Proteomes:UP000287772}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S-NIH.Pt15_0812 {ECO:0000313|EMBL:RSU52319.1,
RC   ECO:0000313|Proteomes:UP000287772};
RA   Johnson R.C., Deming C., Conlan S., Zellmer C., Michelin A., Lee-Lin S.-Q.,
RA   Thomas P.J., Park M., Weingarten R.A., Less J., Dekker J.P., Frank K.M.,
RA   Musser K.A., Mcquiston J.R., Henderson D.K., Lau A.F., Palmore T.N.,
RA   Segre J.A.;
RT   "Genomic and Epidemiologic Investigation to Identify Sphingomonas koreensis
RT   Point Sources in an Indolent Hospital Outbreak.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000256|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632, ECO:0000256|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000256|ARBA:ARBA00007391, ECO:0000256|HAMAP-
CC       Rule:MF_01902}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RSU52319.1}.
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DR   EMBL; QLJH01000005; RSU52319.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A430BL07; -.
DR   OrthoDB; 9803237at2; -.
DR   Proteomes; UP000287772; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   CDD; cd07434; PHP_PolIIIA_DnaE2; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DnaE2.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF4; ERROR-PRONE DNA POLYMERASE; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01902};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_01902};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_01902};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW   Rule:MF_01902};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|HAMAP-Rule:MF_01902};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW   Rule:MF_01902}; Reference proteome {ECO:0000313|Proteomes:UP000287772};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_01902}.
FT   DOMAIN          8..75
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
FT   REGION          1028..1071
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1029..1052
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1081 AA;  119784 MW;  281F262936EB7786 CRC64;
     MASPTTYVEL QVTSHFSFLR GASSPDELFS AAALLGHRAL GIADLGSVAG LVRAWAAQKA
     TGVRLIAGAR VVLDDGRALL LYPIDRPGWS RLTRLLSIGK ARAGKGGCTL GWADLPEWQE
     GLIAILLPGD PGAAAARDLA DLRAVFGDRG YCGLTFRRRP NDAMRLHELA RQAGMAGVRA
     VALGDVLYHA PEVRPLQDVV TAIREKRTID TLGYARERHA DRHLKSPGEM ERRFVAFPDA
     IAATATIARA CTFDLGELSY QYPHERVMDG LTAQQALERM TGEAAERKFP DGVPEAYRRQ
     IDHELRLIGE LGYAPYFLTV NSIVAESRRR GILCQGRGSA ANSCVCYLLG ITSIDPIKHE
     LLFERFVSGE RREPPDIDVD FEHERREEII QWIYDSYGRT HAALTAVVTR YRARGAMREV
     GKALGLPEDL TRALAGLVWG WSEEGVGEKQ VGQLGLNMDD RRLRLALDLA RRLIGTPRHL
     SQHPGGFVLT HDRLDDLVPI EPAAMDKRQV IEWDKDDIDA LQFMKVDVLG LGMLGCMNRA
     FTLLADAKDV HVGMADLQDD DPAVYAMIQK ADTLGTFQIE SRAQMAMLPR MKPAEFYDLV
     IEVAIVRPGP IQGDMVHPYL RRREKIERPD YPRPELRAVL EKTLGVPLFQ EQAMKVAIVG
     AGFTPAEADQ LRRAMATFKF TGGVHHFYEK LVGGMVANGY PRDFAERTFK QIEGFGSYGF
     PESHAASFAK IAYASCWMKH HHPDVFCAAL LNAQPMGFYA PAQIVRDAQE HGVEIRPACI
     NASRWDCTLE ATAGRYLAVR LGLRQVRGLA NVHGAAIVGA RGHLPFESVE DLWRRADIPR
     AAIERLAEAD AFHRLGADRR QGLWKARGLD EAPLPLFAAA AGREPEVALR PLTEGREVVE
     DYRALQLSLR AHPLAFLRDE LTRRGVTRAA DLAQLRDGRH VEVAGLILVR QKPGSAKGVL
     FITIEDETGI ANGILWPDRF EAQRRTVMSA SMIGMKGRVQ REGQVIHVIC DRIVDHGDLL
     AQVGRMDFRP RTGRGDGARH PGAPDRGDAG WRPGPRDSYW PSHATGMDPE QVVRIKSRDF
     H
//
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