ID A0A430FWX7_9BIFI Unreviewed; 705 AA.
AC A0A430FWX7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 13-SEP-2023, entry version 13.
DE SubName: Full=PTS mannose transporter subunit IIABC {ECO:0000313|EMBL:RSX58870.1};
GN ORFNames=D2E24_0166 {ECO:0000313|EMBL:RSX58870.1};
OS Bifidobacterium samirii.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=2306974 {ECO:0000313|EMBL:RSX58870.1, ECO:0000313|Proteomes:UP000287470};
RN [1] {ECO:0000313|EMBL:RSX58870.1, ECO:0000313|Proteomes:UP000287470}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2033B {ECO:0000313|EMBL:RSX58870.1,
RC ECO:0000313|Proteomes:UP000287470};
RA Lugli G.A., Duranti S., Milani C.;
RT "Characterization of the phylogenetic diversity of five novel species
RT belonging to the genus Bifidobacterium.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RSX58870.1}.
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DR EMBL; QXGK01000001; RSX58870.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A430FWX7; -.
DR OrthoDB; 9797715at2; -.
DR Proteomes; UP000287470; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00212; PTS_IIB_glc; 1.
DR Gene3D; 2.70.70.10; Glucose Permease (Domain IIA); 1.
DR Gene3D; 3.30.1360.60; Glucose permease domain IIB; 1.
DR InterPro; IPR011055; Dup_hybrid_motif.
DR InterPro; IPR036878; Glu_permease_IIB.
DR InterPro; IPR018113; PTrfase_EIIB_Cys.
DR InterPro; IPR001127; PTS_EIIA_1_perm.
DR InterPro; IPR003352; PTS_EIIC.
DR InterPro; IPR013013; PTS_EIIC_1.
DR InterPro; IPR001996; PTS_IIB_1.
DR NCBIfam; TIGR00830; PTBA; 1.
DR PANTHER; PTHR30175; PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN; 1.
DR PANTHER; PTHR30175:SF1; PTS SYSTEM ARBUTIN-, CELLOBIOSE-, AND SALICIN-SPECIFIC EIIBC COMPONENT-RELATED; 1.
DR Pfam; PF00358; PTS_EIIA_1; 1.
DR Pfam; PF00367; PTS_EIIB; 1.
DR Pfam; PF02378; PTS_EIIC; 1.
DR SUPFAM; SSF51261; Duplicated hybrid motif; 1.
DR SUPFAM; SSF55604; Glucose permease domain IIB; 1.
DR PROSITE; PS51093; PTS_EIIA_TYPE_1; 1.
DR PROSITE; PS00371; PTS_EIIA_TYPE_1_HIS; 1.
DR PROSITE; PS51098; PTS_EIIB_TYPE_1; 1.
DR PROSITE; PS01035; PTS_EIIB_TYPE_1_CYS; 1.
DR PROSITE; PS51103; PTS_EIIC_TYPE_1; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW Reference proteome {ECO:0000313|Proteomes:UP000287470};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 131..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 475..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..86
FT /note="PTS EIIB type-1"
FT /evidence="ECO:0000259|PROSITE:PS51098"
FT DOMAIN 122..510
FT /note="PTS EIIC type-1"
FT /evidence="ECO:0000259|PROSITE:PS51103"
FT DOMAIN 575..679
FT /note="PTS EIIA type-1"
FT /evidence="ECO:0000259|PROSITE:PS51093"
FT REGION 535..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 25
FT /note="Phosphocysteine intermediate; for EIIB activity"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00421"
SQ SEQUENCE 705 AA; 74003 MW; 6DFAFFC92D3255FB CRC64;
MAESTASQII EAIGGAGNVT SLTHCATRLR FELVDAGKVD QERLEHMDGV LGAVPQSGDR
FQVVIGGGVA TVYEEIMHLP EMANAGSGAK ASGNGGMSNA DVKAAARAKA RGKVAWLDSF
FEYLADSFRP ILGVLLGASI IIALVNLFIS LGVIAGDEDN TSLMFIKAIW KGVFYFLPIM
VAYNASKKLK VDAWLGGSIM AMLMTPQFTS LSNQETWGDA VKCVENTTLG TTDCTATVFG
LPMQLSDYSG NVFVPLMMAA VLALVYHGLK RIIPESVQLV FVPFFAMIIV GTLTAFLIGP
LGVWVGNGLG VVLAWMNSHA PFIFAIAIPL LYPFLVPLGL HWPLNALMLM NIQSMGYDFI
QGPMGVWNFA CFGTTAGVLF LSIKDKDKEM RQTAIGALAA GLLGGVSEPS LYGIHLRYKM
IYKRMLVGCG VGGVVIAILG WLFPSVTAAG ETVHGVTTTA FAFTSLLTIP VFDQMWVYGV
SIAVAFVVAF LMIVTFDYRT PEQKAEVLAR VAQEQEDRKL EAQAAAAPAP AAAPAPAPAA
AAEAAPAEPA APVEPTREVV SPVAGHVIDL SETGDAVFAS RALGEGVAVV PTESVVKAPV
SGTLKTVAKT GHAFGIKTDD GVEVLVHIGI DTVKMEGDGF DVAVAKGQRV SAGDPLATVD
FDKVTAAGYS TATIIAVTNT KKLASVTPLT GKDVAAGDPV IAVER
//
