ID A0A430QGX1_SCHBO Unreviewed; 781 AA.
AC A0A430QGX1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=SAM-dependent MTase RsmB/NOP-type domain-containing protein {ECO:0000259|PROSITE:PS51686};
GN ORFNames=DC041_0006658 {ECO:0000313|EMBL:RTG86940.1};
OS Schistosoma bovis (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6184 {ECO:0000313|EMBL:RTG86940.1, ECO:0000313|Proteomes:UP000290809};
RN [1] {ECO:0000313|EMBL:RTG86940.1, ECO:0000313|Proteomes:UP000290809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TAN1997 {ECO:0000313|EMBL:RTG86940.1,
RC ECO:0000313|Proteomes:UP000290809};
RA Oey H., Zakrzewski M., Gobert G., Gravermann K., Stoye J., Jones M.,
RA Mcmanus D., Krause L.;
RT "Genome sequence of the bovine parasite Schistosoma bovis Tanzania.";
RL PLoS Pathog. 0:0-0(2019).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SYS1 family.
CC {ECO:0000256|ARBA:ARBA00008160}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RTG86940.1}.
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DR EMBL; QMKO01001740; RTG86940.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A430QGX1; -.
DR STRING; 6184.A0A430QGX1; -.
DR Proteomes; UP000290809; Unassembled WGS sequence.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 6.20.240.40; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR019185; Integral_membrane_SYS1-rel.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12952:SF0; PROTEIN SYS1 HOMOLOG; 1.
DR PANTHER; PTHR12952; SYS1; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR Pfam; PF09801; SYS1; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000290809};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 441..780
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT BINDING 591
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 781 AA; 89441 MW; D0E3DCFD47B7DAAE CRC64;
MASGFRSTVW DPILIISQIV FMQCIFYISA GSISGLLLII ISHNLPTLDM IFIDTKIHFP
DSIGICLFIG FLLTPLICSI GLWFIVKRSK QCLDFSCTIH FWHFIFCIIY SHSFPQSILW
WIVNLLSIAI MTVMGEFLCM RSEMAEIPLR STYSGRPTVL CGESYVLQQR LSNMTLYIPM
NPSREWTLNK THVKVALRRY GFAIKEHYIT LPKEEITSKN STSSFKISVN IDDIVNVVVP
CSIFLYQKLD KGMCTQPPTN VFRKIKIEDW TADFSETDIL KKIGNSRRFF SYFKRQAYEP
TKIKQLDDSS IGFMLSDLNH NGRVALAHFD HYYSEAYGPV AWRSMRIALL MPSKKAILYN
RYFPNVSETI SSSYNNDDNQ SFLPNINFMQ TLIKHQNSLT NNVFNADKNP NIIDEVINVT
QSDARRRQFL TRYSPSDENM DTTNLNEFIP STELISENEM YTRECDTDFT FYSKDYYGMI
KADEGDSSDL HSLKVLTEEF RIPEKLCIKC SPPDFHTIDL SSVIPILVLN LQKNDNMVNM
STFSGTKSVI ALQTGLLNRL LCVIRTPSRT THVQQMINTF KSSGINSKEN DKQNNNTKID
FVYSNDELAG YFSDNIDKDY KFNKILVNVP CSADRYAITS GATHVFEMGQ AHLRAHLPKI
QLNLLRQAME LCQPNGYVVY STSTLSPGQN QEIIQSFILN HSKNINFTLI NLKPLYDLLT
VCYSKLGLKI IPIHLPLFDN MNENNHNTNL SSNNTCHGLL IIPSISCNYG PTFIVKFKRL
P
//
