ID A0A430QMN3_SCHBO Unreviewed; 3425 AA.
AC A0A430QMN3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 13-SEP-2023, entry version 13.
DE SubName: Full=Polycystin 1L2 {ECO:0000313|EMBL:RTG88968.1};
GN ORFNames=DC041_0001913 {ECO:0000313|EMBL:RTG88968.1};
OS Schistosoma bovis (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6184 {ECO:0000313|EMBL:RTG88968.1, ECO:0000313|Proteomes:UP000290809};
RN [1] {ECO:0000313|EMBL:RTG88968.1, ECO:0000313|Proteomes:UP000290809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TAN1997 {ECO:0000313|EMBL:RTG88968.1,
RC ECO:0000313|Proteomes:UP000290809};
RA Oey H., Zakrzewski M., Gobert G., Gravermann K., Stoye J., Jones M.,
RA Mcmanus D., Krause L.;
RT "Genome sequence of the bovine parasite Schistosoma bovis Tanzania.";
RL PLoS Pathog. 0:0-0(2019).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RTG88968.1}.
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DR EMBL; QMKO01001537; RTG88968.1; -; Genomic_DNA.
DR STRING; 6184.A0A430QMN3; -.
DR Proteomes; UP000290809; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00146; PKD; 1.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF193; LOCATION OF VULVA DEFECTIVE 1; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00308; LH2; 1.
DR SMART; SM00089; PKD; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 1.
DR PROSITE; PS50095; PLAT; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023069};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000290809};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2400..2418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2608..2627
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2650..2671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2747..2771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2783..2809
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2885..2904
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3023..3042
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3080..3099
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3119..3137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3157..3178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3208..3227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3247..3269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3309..3330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 497..541
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 2443..2562
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DISULFID 2966..2979
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 3425 AA; 385022 MW; 0BE11DD22F918B84 CRC64;
MVGNNWTKIV TDPSDCITLC KKNSFTWSAI SNDSFCFCGN NLPPDTELYN SSCLYSETVT
VYRTESNVYI GPFVITTTDL TVKQVGDTIS INFVIPTEFK VLPGVKVYEF DYGDSLQTTE
NISDITIPLV ISYNAPGPVW PTLRARNQDG TITGSASLAL MIYELITPAD ITFNCPLLVM
SGSVFTCQLN CNKGSHIQGT VSFANDWQDT ISLPEPNYDW IGLPPKRMKD TMINYNTNKL
IITGSQARYD GTISTIQIHA LLLTDVTFYL LRVQCTGGMY NFETNSCSST NNRSVTCTAD
QVFSGLVRDC VNISSSYCGN LRQLKLDKPI IVENYDYQVI GIYTVKLTVL GWQSIKLPSV
WTIQSGDRIG FTSILAGSIG CAPSSSYEAD DLETLTTFSG TNGSSVLGSS LKRLTSIRHQ
IGAWIRPTHD ALLTGYINTT GYQDVSLQLY SYWGKNYTSP ALIKTTIMID EIINETQLIL
NSCAAGIQCS LELKSHTGIN VTYVWDFGDG TVQKTTSVKM VQKTYSTVGN YNLIVNISNS
IQYKIIVQNV SVIDKFEFNG IQGNQFTELN GLTTLKLNLS GNRFICSWYL NGVLSKNDSM
TQFDYMHIQS GVVVWNVTCR TPVETISRKL EQFVIERFTG LSLVTKSLQV AKPAQIVFTF
ITGNNLTSQL TFFNQILNTR IDYVQKTITS ELVSESQIAS VNYSLWTTNP ISSNLTTGQI
LFDVPVLGMN IQVEPNYAGP SQNMIFRVSF QEGTSIILTV NYGDGEVIQQ SAMQLQTWPK
DYQLTKKYLN AGGNTENRTV TVYVVDKIGV YAAQAITESV AVYDPATLKI TRQSGNPAVL
TKISLDWGDN SQFTLDDFRE GTVYSHIYKS EGDFGVTALL TNPVDQKVFV TTLKVRARIE
DFGCQVAPNP VETGKLLVIS VVYKSAQDVI ISALLNNRTD SKQINVPAPK LTEINYNYPV
AGLYYEEIQA KNLVSNQSCL LIVDVRNKIV NMNIEYGGHA VYPPGSITFT LTYTGIAANF
PTLAKYKVVW GDGSALSEGM LTLANQPQKI SHVLADLNYF QASVTLDNVI STMTKNTQVA
AFGLFQQIDL IITVASTGDP GYGADGNFYP LGVQLKFQVL ANGKPNNVAN ITYSIINKTN
NLILDSGTVW NNYFFYTFTK FGEYNIVVLA SNPVSAKSTS KEISIRTSIR GLKAYLVGNG
MLEPNQQGII RISFEAYPND ACLCVEKSDG VGPVYYPKLT DPTSFCSLCP SYLRLQDAPV
NLTFSLSVQY GSSGPQYVSI QAISASEIVD TKLYIPVTFS TCPPPKISMS NASSQLTTYP
IKAITSEIIN IEAILTVPDC LLSVPNEKLW TLYSIDLDTT QTLGPISLSQ ELSSKTLRLG
LPANFLSPGP YKATCSAYFT PPQGVPYIVS ESAYIIVVPP PLLVQFDVGN PISKTIDLSI
NEICLKPEVY SLDPAMNNVN VPQGIGSWIW YCRQVDEELS GKLISPKPPG YQYNAYYTGC
FGDGPGVIDT NNEFDSSNLT SWFIPESDDL YVTVLIEFGT LSPDMKFKWN IREMHSDGTL
LPFDQVQQDT YTEGTFTSSW RIKKGYFINK SNDVKGCIVC ATLTKNTDIG TSCLRFKYLP
RPTPGICTYT LNDTNMCVNC VNFTSIVSPL TYTFFLTNSS IKIALASENL PKTCFVVPYM
YSPLDACVYV SDKFGGSIEV CYANIFVQAK SLDLMRAAIQ SLVEDKKAEL NRLVVTGQLT
ESADLVTSYA SAVQMFSTLE TRKSKTFKTV LRFLYNSIRF NNCFCFCSPF SDSAGANNTP
DAIFNRDLRS KAGNSQINNP ISLDIPTDPA LLDYNVDLEK AAMSCTANIL SNTLDVDRSS
QSKLNTYLTE VTESLEAIVC DNTDQLLTMT STIFQSALLL ADVSPKLLFS LQTSGLDPMS
DLMLQNSADQ QSLLVGQTLD MIRNLMTTSQ KVTQGLLIEG APPITFQTSN AVISLSRIPP
NKLSNRIAVL NGSQNDVFVN NLCRNFQALN ESCSESYSLQ TFISKTNLFS FRTGSSIPIP
FHTETISMIL YNNKPVIVKD VKEIVEGIVH RISNFKQPTF TSMDPGTNRP QLPAARIAVD
KTEIYQALLM SHQVVPDDVA VFFQLYPENI SECPQYLLFL RLIDPPVISL STGGYDMWTT
LPEDTSKCVN MTTNPNDPNY RYTFMLDNRQ LMELRSTQKY SERFELLQKS VAQTVYIGFR
QLNQYEINTY KNTSPPLIPY QYRDQINNTA LSRWFLTSCV SGQVDSSKKW STSKCRVGPK
TTVQQTQCIC DEFSTFTSGW FELPNSIDFN YVFANIDFNK NPTLYATEIS LCIIFLLILI
WARREDIKDI EKVGPKTTVQ QTQCICDEFS TFTSGWFELP NSIDFNYVFA NIDFNKNPTL
YATEISLCII FLLILIWARR EDIKDIEKLT VTQLSENNPD CEYFYEIIVS TGHRRCGGTD
SKVCFILSGQ YGETGCYVLQ DPNRKVLCRG ATDRFLLACP KPLGPLIYIR LWHDNSGVGD
KASWYCNYVG VVDLQTREKS HFIVESWFAV EEGDGQVDRI IPVTSQEEML TFIHMFSTTA
SRNMTDDHLW ISVVARPIFS RFTRVERVAC CLLLLYLSML GSCMFYKGEG SVKQPNLISL
GPFGFTPTEF YVAIVNNLLT FIPLFLIIYI FRNSRLRVSH ATKLRHAIEE HLDEKLYIGK
ASFIYSTQSA IQDTSKNDDR EALAENADDT EGKEKGRTLF CGWQMRIFAW LLLIICLGIA
VTFTTFYGVM FGEATCKKWL SSLFLSFFIS VLLAQPIKVL LLAVFFSFIC KSTDRVDQIE
IFEEEDRIIQ TLGKRYQLRM DREYLNNNYL SDDFRPQRLV ILPPDPSDLA RARAYRLKQR
RANDIIREVI LYVFFLTLLL IVSLDFRDAN GFLLKSSLQN LFFPSSFQSM NDVDDFYKWA
QNVLIPGLRA DRWYNRNPPL FQRDSCNVHE LAKHLFKHCY GSYDMFNEDK EAYGISWAKF
EGNDKSNNSA PEFVYQNSSQ LKGYPYLGQI TWYSGGGYVH LLRGSKDEML DRMSFLNQTH
WIEFSTRAII VQFTVYNPNI NLFAIITALI EMPGIGAMIP SYRIETANLF GVLGSKTKLA
QITSQALFAF ILFCYLIKEL RSMFRQRLKY FTKFWNFVEL FIICGSIAAI AAYIYMILST
KSSIEEFSRT HGNIYMNFQL LAYWNENLTY LTAIICFFAM LKLVYLFRFN QRVGLLGSVL
KYAATDLKYF CFIFLVVFSA FVLVFYLLYN DTLSGFKTIL NAIETSMQII LGKFDFTSMY
ERQMVLGPLL FAAFSLCVVF VMVSMFIAIL DESFQRVLKD LSLQSDDHEM TQFIAIQFIQ
SIGLDRTTWG KNFIKNVNTQ QQEPIYDPES ESSKHVAQLK SLMNEFLEHV QQNLITEERK
PVDSK
//