ID A0A432WC48_9GAMM Unreviewed; 234 AA.
AC A0A432WC48;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=DNA mismatch repair protein MutH {ECO:0000256|HAMAP-Rule:MF_00759};
DE AltName: Full=Methyl-directed mismatch repair protein {ECO:0000256|HAMAP-Rule:MF_00759};
GN Name=mutH {ECO:0000256|HAMAP-Rule:MF_00759};
GN ORFNames=CWE14_14450 {ECO:0000313|EMBL:RUO29654.1};
OS Aliidiomarina soli.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Idiomarinaceae; Aliidiomarina.
OX NCBI_TaxID=1928574 {ECO:0000313|EMBL:RUO29654.1, ECO:0000313|Proteomes:UP000287823};
RN [1] {ECO:0000313|EMBL:RUO29654.1, ECO:0000313|Proteomes:UP000287823}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Y4G10-17 {ECO:0000313|EMBL:RUO29654.1,
RC ECO:0000313|Proteomes:UP000287823};
RX PubMed=30364313; DOI=.3389/fmicb.2018.02453;
RA Liu Y., Lai Q., Shao Z.;
RT "Genome-Based Analysis Reveals the Taxonomy and Diversity of the Family
RT Idiomarinaceae.";
RL Front. Microbiol. 9:2453-2453(2018).
CC -!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated GATC
CC sequences. It is involved in DNA mismatch repair. {ECO:0000256|HAMAP-
CC Rule:MF_00759}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00759}.
CC -!- SIMILARITY: Belongs to the MutH family. {ECO:0000256|HAMAP-
CC Rule:MF_00759}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RUO29654.1}.
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DR EMBL; PIPO01000007; RUO29654.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A432WC48; -.
DR Proteomes; UP000287823; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006304; P:DNA modification; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd00583; MutH-like; 1.
DR Gene3D; 3.40.600.10; DNA mismatch repair MutH/Restriction endonuclease, type II; 1.
DR HAMAP; MF_00759; MutH; 1.
DR InterPro; IPR004230; DNA_mismatch_repair_MutH.
DR InterPro; IPR011337; DNA_rep_MutH/RE_typeII_Sau3AI.
DR InterPro; IPR037057; DNA_rep_MutH/T2_RE_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR NCBIfam; TIGR02248; mutH_TIGR; 1.
DR Pfam; PF02976; MutH; 1.
DR SMART; SM00927; MutH; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00759};
KW DNA damage {ECO:0000256|HAMAP-Rule:MF_00759};
KW DNA repair {ECO:0000256|HAMAP-Rule:MF_00759};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW Rule:MF_00759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00759};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00759};
KW Reference proteome {ECO:0000313|Proteomes:UP000287823}.
FT DOMAIN 63..161
FT /note="DNA mismatch repair MutH/Type II restriction enzyme
FT Sau3AI"
FT /evidence="ECO:0000259|SMART:SM00927"
SQ SEQUENCE 234 AA; 25884 MW; 012BB45B7F85DD2C CRC64;
MSDYLQLPQV PSHPPADEQQ LLTRARALAG MPLGWLAEQA GWVTPDTLSR AKGWSGQLIE
LYLGASAGSR PEQDFPELGI ELKTIPVNSS GTPLETTYVC IAPLLGLNGV SWQQSNVRNK
LQKVLWVPLD GRREVKPADR CIGMPFLWQP AADEDALLRA DWEEITERII LGQIQQITAR
HGQALQLRPK AANSKALTAA IGPEGDTIQT LPRGYYLKTD FTARILQRAL QNSW
//
