ID   A0A432Z3L6_9GAMM        Unreviewed;      1164 AA.
AC   A0A432Z3L6;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=CWI80_07880 {ECO:0000313|EMBL:RUO72465.1};
OS   Pseudidiomarina sediminum.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC   Idiomarinaceae; Pseudidiomarina.
OX   NCBI_TaxID=431675 {ECO:0000313|EMBL:RUO72465.1, ECO:0000313|Proteomes:UP000287022};
RN   [1] {ECO:0000313|EMBL:RUO72465.1, ECO:0000313|Proteomes:UP000287022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=c121 {ECO:0000313|Proteomes:UP000287022};
RX   PubMed=30364313; DOI=.3389/fmicb.2018.02453;
RA   Liu Y., Lai Q., Shao Z.;
RT   "Genome-Based Analysis Reveals the Taxonomy and Diversity of the Family
RT   Idiomarinaceae.";
RL   Front. Microbiol. 9:2453-2453(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RUO72465.1}.
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DR   EMBL; PIQE01000002; RUO72465.1; -; Genomic_DNA.
DR   RefSeq; WP_026860345.1; NZ_PIQE01000002.1.
DR   AlphaFoldDB; A0A432Z3L6; -.
DR   STRING; 1122124.GCA_000423165_01573; -.
DR   Proteomes; UP000287022; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   CDD; cd07433; PHP_PolIIIA_DnaE1; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR048472; DNA_pol_IIIA_C.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR049821; PolIIIA_DnaE1_PHP.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF20914; DNA_pol_IIIA_C; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          7..74
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
SQ   SEQUENCE   1164 AA;  130711 MW;  5E191BE3FB8365EA CRC64;
     MTAPQFIHLR VHSDFSMIDG LAKVGPICEA TANAQMPAFA LTDQMNMCGL VRFYRTAHGK
     GLKPIVGCDL WVLPDDWNDD SQETPFRLTA LAMNNEGYQQ LTQLISRGYL AGHRAGRPCI
     NKGWLAEHAE GLLLLSGGRE GDIGRKLLQN RKAEAETELA FYQQYFPDRF YLELLRTGRP
     QEDDYLHAAV ALAAEQDVPV VATNEVVFLK PEDFQAHEVR VAVADGYTLD DKRRPKKYSR
     EQYLKTPEEM LDLFADIPEA IANTIEIAKR CNVTITLDEY VLPAFPTGGM SPEDFLVKKS
     EEGLEERLEA LFPDPEERAK QRPEYDERLK IELDVINQMG FPGYFLIVME FIQWSKDNGI
     PVGPGRGSGA GSLVAYALKI TDLDPLELDL LFERFLNPER VSMPDFDIDF CMERRDEVID
     HVAELYGREA VSQIITFGTM AAKASIRDVG RVLGHPYGFV DKITKLVPGD PGMTLAKAFE
     IEPRLNEMYD QDEDVRDLID MARILEGVTR NAGKHAGGVV IAPDKITDFS PLYCDEEGKQ
     PVTQFDKNDV ESAGLVKFDF LGLRTLTIIQ WALDMVNAKR ARQNAAPIAI EKIPLDDPRC
     FQLLKKAQTT AVFQLESSGM KQLIKKLLPD SFEDIIALVA LFRPGPLQSG MVDNFIDRKH
     GREPISYPDK DYQHEWLQPI LEPTYGVILY QEQVMQIAQV LAGYSLGGAD LLRRAMGKKK
     PEEMAKQREV FAEGAKKMGI DPDLAMKIFD LVEKFAGYGF NKSHSAAYAL VSYQTLWMKT
     HYPAEFMAAV MSADMDNTDK IVTLVDECEQ MGLKLLPPDV NVGQYKFTVD EQGNVVYGIG
     AIKGVGEGPI EAILSARQEG GSFKDLFDFC CRVDLKKLNR RVLERLIRAG AMDSLGPHRA
     ALVATLEKAM RQAEQHARAE AIGQTDLFGV LAPTDDSDAP AAEFENVAPW PEARWLDGER
     ETLGLYLTGH PINRYRSELR NYVPANLANV RPTGREQMTS IAGLVIDLRV MVNKKGARWA
     IVTLDDKTAR FDVRFFAQDY ETYEHLLAKD QILVIKGEVS FDDYSGGNTM TAREVMTITG
     IREQYAKGLR ITVRPEHLEG KALQQLLQTL EPYKGGACPL VFDYHRTDVK ATYNAGTEWF
     VTPEDELLYE LEQQLGAQHV TLEF
//