ID A0A432ZK74_9GAMM Unreviewed; 543 AA.
AC A0A432ZK74;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE SubName: Full=Tryptophan 7-halogenase {ECO:0000313|EMBL:RUO78230.1};
GN ORFNames=CWI83_04125 {ECO:0000313|EMBL:RUO78230.1};
OS Pseudidiomarina taiwanensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Idiomarinaceae; Pseudidiomarina.
OX NCBI_TaxID=337250 {ECO:0000313|EMBL:RUO78230.1, ECO:0000313|Proteomes:UP000288279};
RN [1] {ECO:0000313|EMBL:RUO78230.1, ECO:0000313|Proteomes:UP000288279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PIT1 {ECO:0000313|EMBL:RUO78230.1,
RC ECO:0000313|Proteomes:UP000288279};
RX PubMed=30364313; DOI=.3389/fmicb.2018.02453;
RA Liu Y., Lai Q., Shao Z.;
RT "Genome-Based Analysis Reveals the Taxonomy and Diversity of the Family
RT Idiomarinaceae.";
RL Front. Microbiol. 9:2453-2453(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RUO78230.1}.
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DR EMBL; PIQG01000002; RUO78230.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A432ZK74; -.
DR OrthoDB; 7178350at2; -.
DR Proteomes; UP000288279; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000288279}.
FT ACT_SITE 81
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 11..14
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 81
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 337
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 346
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 543 AA; 62153 MW; B4B031A79B2EF083 CRC64;
MQKKKVLIVG GGSAGWMAAA YLNGALNQRG ERPRVDIQLL ESPDTPRISV GEATIPSMRH
LLSVVGVDEL DFMKSTNASF KQSIRYTNWV HNDMSFYHHP FSSMRRQPLD RAGMDWLMSD
QSIPFMETCS VQPILCEWGL APVMLGKWDM GAPLNYAYHM NAQKFADYLR DFSTPRGVVH
TLANMVDVVM RDDGHIAAVR TDKGETIEAD LFVDSTGFSA QLIEQQIGVG FEDCSQYLLC
DRAVTMHLPY ETHFPGMVRP YTTATALSNG WIWDIPQNDR RSIGYVHSSA FIDKEAAERE
MRAYQGGNTD DLPARFVDFK VGRRKQIWSK NVIAIGLAGG FIEPLESTGL YLSDLGAVLL
AEHFPWHDDG MEQLASRYNH IMSNRFYEIL DFINMHYCLT KRTDTEFWKT VQLREHITDR
LQAKFDFWRF KPPTPHDFQD QWFSGMSQAP QAADLCSHDR RPAVDTGGLW NHESYECILF
GMEFLKEESE QWFGPNRPAT QVHPAIIQRL QMARQKLPPH HIWLNRVLGM PQYPMAYKPV
GWG
//
