ID A0A432ZMP5_9GAMM Unreviewed; 1157 AA.
AC A0A432ZMP5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=CWI83_01115 {ECO:0000313|EMBL:RUO79141.1};
OS Pseudidiomarina taiwanensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Idiomarinaceae; Pseudidiomarina.
OX NCBI_TaxID=337250 {ECO:0000313|EMBL:RUO79141.1, ECO:0000313|Proteomes:UP000288279};
RN [1] {ECO:0000313|EMBL:RUO79141.1, ECO:0000313|Proteomes:UP000288279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PIT1 {ECO:0000313|EMBL:RUO79141.1,
RC ECO:0000313|Proteomes:UP000288279};
RX PubMed=30364313; DOI=.3389/fmicb.2018.02453;
RA Liu Y., Lai Q., Shao Z.;
RT "Genome-Based Analysis Reveals the Taxonomy and Diversity of the Family
RT Idiomarinaceae.";
RL Front. Microbiol. 9:2453-2453(2018).
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RUO79141.1}.
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DR EMBL; PIQG01000001; RUO79141.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A432ZMP5; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000288279; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR CDD; cd18810; SF2_C_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11140; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR048635; MFD_D3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21132; MFD_D3; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000288279}.
FT DOMAIN 623..784
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 805..959
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1157 AA; 130195 MW; 34E270E854A1D13B CRC64;
MHQNVLFSGQ IPAQAGQDKT WLELQGSSPA LAIAELAQAG SEPVLIVAAD APQAHRLELE
IKAFAADLEV VLFPDWETLP YDSFSPHQDI ISERLSTLAK LPELRRGVIV VTLSTLLQRI
APTDYVAGYT LQLQQGQQLD IHALRQRLEH AGYRAVQQVL EHGEFCARGS LLDLYPMGSK
VPFRIDFFDD EIDSIRIFDP ETQLSQETVN QISLLPAHEF PLTDSAIELF RGQYRDLFGP
SNERDSVYYQ VSQKELPGGI EFYLPLFFEQ TATLFDYLPD TTLLVTFGNI QGQLEQLWHD
IQQRYEQRRY DPLRPLLAPQ QLFLASEQLY SKFKAYRRVR VQVPTEHAKP GPIRFKTAAV
TEVAVNHQLK DPLAPLRQKL LSWQQDNYRV LFVVESAGRR ESLRDLLKPL NLSLTEIEHL
ADFIREPETS TAIWVAPIVN SFELADAKLV VLSETELLGN RIAQRRRRDS SSNSQENMVR
NLAELQIGQP VVHIDHGVGR YQGLQTLDAG GMPTEFVTIE YAGGSKLYVP VAALNVLSRY
SGGEESSAPL HKLGNDSWDK AKRRAAEKIR DVAAELLDVY AQREAKPGYA FKVNQEEFER
FSASFPFEET DDQIAAIASV YADMVAPRAM DRLVCGDVGF GKTEVAMRAA FIAANDGKQV
AVLVPTTLLA QQHYENFKDR FADWPFRVEV LSRFRSSKQT KQTLDDIAAG KVDIVVGTHK
LLQNDVKFHD LGLLIVDEEH RFGVRQKEAV KRLRADVDIL TLTATPIPRT LNMAMNGVRD
LSIIATPPAK RLAVKTFVRE YDAPTVREAI LREILRGGQV YYLHNNVETI DKTARELAEL
VPEARITIAH GQMRERELER VMSDFYHQRF NVLVCTTIVE TGIDVPSANT IVMDRADHLG
LAQLHQLRGR VGRSHHQAYA YLLTPNPKRM TKDAVKRLAA ISQLEDLGAG FMLATHDLEI
RGAGELLGEE QSGQIETIGF SLYMEMLEQA VKALQAGKEP ALDQLLKAQT EVELKVPALL
PDTYIADVNL RLNLYKRIAS CSNLTDLEQL QVEMIDRFGL LPEQAKNLVR VTALRNRAEN
LGIKKIEGGL SALTIEFSAQ PKVSASYLIQ LIQTQPQQFK LEGANRLRVL GKMEDTQERL
KLVESLLDDF DQNAQQA
//
