ID   A0A433SE16_9BURK        Unreviewed;       416 AA.
AC   A0A433SE16;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   RecName: Full=Peptidase M50 domain-containing protein {ECO:0000259|Pfam:PF02163};
GN   ORFNames=CUZ56_00917 {ECO:0000313|EMBL:RUS66980.1};
OS   Saezia sanguinis.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales; Saezia.
OX   NCBI_TaxID=1965230 {ECO:0000313|EMBL:RUS66980.1, ECO:0000313|Proteomes:UP000286947};
RN   [1] {ECO:0000313|EMBL:RUS66980.1, ECO:0000313|Proteomes:UP000286947}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CNM695-12 {ECO:0000313|EMBL:RUS66980.1,
RC   ECO:0000313|Proteomes:UP000286947};
RA   Medina-Pascual M.J., Valdezate S., Monzon S., Cuesta I., Carrasco G.,
RA   Villalon P., Saez-Nieto J.A.;
RT   "Saezia sanguinis gen. nov., sp. nov., in the order Burkholderiales
RT   isolated from human blood.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the peptidase M50B family.
CC       {ECO:0000256|ARBA:ARBA00007931}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RUS66980.1}.
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DR   EMBL; PQSP01000002; RUS66980.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A433SE16; -.
DR   OrthoDB; 9782003at2; -.
DR   Proteomes; UP000286947; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd05709; S2P-M50; 1.
DR   InterPro; IPR008915; Peptidase_M50.
DR   Pfam; PF02163; Peptidase_M50; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286947};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        41..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        72..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        160..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        187..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          84..183
FT                   /note="Peptidase M50"
FT                   /evidence="ECO:0000259|Pfam:PF02163"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   416 AA;  46356 MW;  D2E9A2C7D63DC6B8 CRC64;
     MQQTEATLTA APVPSTEKNG GLYPPMEILQ KQKKSQPKRR HWLGAAGWFL MVAVLTIAFM
     EPRSLDKVWG DWIFYLGLAL IFLTISIPIN IILHEVGHML AGLFCGMRLL VLSVGRWRFE
     RSVQGFRLRR ATPIAGISGL AMMVPDVTHT RASPKRDHVI IFLGGPVMNL ACAALALVAA
     YALSLHLIVN VFLYTFGAMA LFVGVLNLMP LKIQNWRTDG LQIIDVFRHK EDILMQNIQY
     LSGLALTGIR ARQWPPELIP QEQVAGDGAL PFFTRISAQN ARLIYALDCD DEKMARPCVE
     WLAKHFDQIP DGLRQLVAVL IASYAAQMCG DKDLLAAWRP WCDGGLTDTG AVCHWLDAEL
     AWLNGDALKA RKYIQQAQAA MSTVMSRVDQ QMLEESLSSL QLRMRGGHQE ICHTGS
//