ID A0A433SEE4_9BURK Unreviewed; 427 AA.
AC A0A433SEE4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN Name=rstB {ECO:0000313|EMBL:RUS67102.1};
GN ORFNames=CUZ56_01041 {ECO:0000313|EMBL:RUS67102.1};
OS Saezia sanguinis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales; Saezia.
OX NCBI_TaxID=1965230 {ECO:0000313|EMBL:RUS67102.1, ECO:0000313|Proteomes:UP000286947};
RN [1] {ECO:0000313|EMBL:RUS67102.1, ECO:0000313|Proteomes:UP000286947}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CNM695-12 {ECO:0000313|EMBL:RUS67102.1,
RC ECO:0000313|Proteomes:UP000286947};
RA Medina-Pascual M.J., Valdezate S., Monzon S., Cuesta I., Carrasco G.,
RA Villalon P., Saez-Nieto J.A.;
RT "Saezia sanguinis gen. nov., sp. nov., in the order Burkholderiales
RT isolated from human blood.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RUS67102.1}.
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DR EMBL; PQSP01000002; RUS67102.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A433SEE4; -.
DR Proteomes; UP000286947; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR44936:SF9; SENSOR HISTIDINE KINASE GLNK; 1.
DR PANTHER; PTHR44936; SENSOR PROTEIN CREC; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000286947};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:RUS67102.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 157..209
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 217..419
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 427 AA; 47776 MW; 9473E12CB9CCD39D CRC64;
MVLFSRSAAT ASQTPPPSKS LPWYRGLWWS IWITLIATVF IYGITTALIF RFLVAPSIIA
EREAIRMENE QTRQEYHQYI REQRDSYYRQ LLEWREHAPP GTPVPAFDFE RPARFGHGGR
GPGSEMHNNE PPGIFKPWIW LGLMVIVMGA ATYPIARKLT RRLEKLQRGV ENFGSGNLKT
RVDITGHDEV SLLAHSFNIS AQHIEALVSQ HKQLLAQVSH ELRTPLARLR MSTELAAEQM
PQIADDLRTD IKELDELVGE ILLASRLDAA PDALHITSFD ALALAAEEAS RTNAELHGQS
VEVQADEALV RRALRNLLIN AERYAPDTLI ELHITYEAAR QGHPAQVCFS VSDRGPGVSD
ADRERIFEPF FRVKNAVPGG TGLGLSLVKQ IALRHRGSVV CLPREGGGSR FELRIPVHPV
TANYQAA
//
