ID A0A433SLE4_ELYCH Unreviewed; 1130 AA.
AC A0A433SLE4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:RUS69964.1};
GN ORFNames=EGW08_022272 {ECO:0000313|EMBL:RUS69964.1};
OS Elysia chlorotica (Eastern emerald elysia) (Sea slug).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Sacoglossa; Placobranchoidea;
OC Plakobranchidae; Elysia.
OX NCBI_TaxID=188477 {ECO:0000313|EMBL:RUS69964.1, ECO:0000313|Proteomes:UP000271974};
RN [1] {ECO:0000313|EMBL:RUS69964.1, ECO:0000313|Proteomes:UP000271974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC2010 {ECO:0000313|EMBL:RUS69964.1};
RC TISSUE=Whole organism of an adult {ECO:0000313|EMBL:RUS69964.1};
RA Cai H., Li Q., Fang X., Li J., Curtis N.E., Altenburger A., Shibata T.,
RA Feng M., Maeda T., Schwartz J.A., Shigenobu S., Lundholm N., Nishiyama T.,
RA Yang H., Hasebe M., Li S., Pierce S.K., Wang J.;
RT "A draft genome assembly of the solar-powered sea slug Elysia chlorotica.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RUS69964.1}.
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DR EMBL; RQTK01001525; RUS69964.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A433SLE4; -.
DR STRING; 188477.A0A433SLE4; -.
DR Proteomes; UP000271974; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF133; INTEGRIN ALPHA-PS2; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 3.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 2.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000271974};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1069..1091
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 311..375
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 378..435
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 486..637
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 639..788
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT REGION 1108..1130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1116..1130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1130 AA; 124361 MW; 166F2DCBDF1FB91F CRC64;
MRLPSLQSLT SVRWKNYLLL CAVSLLLAPL VRVSAFNIGT SGARVIRGNA DTLFGTTLHF
LPETSKLKSP GELMLLVSAP KENTTTTTGN KALGAVHTCT DIFKPSPSCS PFHDRADLNI
RNAERRELFG FAVAVNDDGS SIICSPHFTD TNPRSAYFSI GRCSVVNEST PNTGHEYTPF
YNAQDQWRRY VGVVNVSPTV KKTAYFEGLA SYGFSVDSKM GDFFVAGAPG VMEGEGTVVY
TDFDNNLIKF NVPFKYNLNT TAYGYLGYDV KIGQFCDNSE ICFAASSPNL NRIGAVQIFK
KVNKEGSDDL ERIQFIQGSQ AWAYFGYSLA ACDVNNDGWD ELLVGTPHFT DVDNANGQDQ
GRVFVYSRTD SNQDLQHHIT LEGSRSQFGR FGSTVQCLGD INLDGYMDVA VGAPSEDNGA
GNVHIYLGSS SGLSNPSNQR ITASSLPVPL NGIGYAVSRS HTIPGSKYPI IAISSVAEDT
VVVLSTRPIV DANVTLVATP NLIDLNEVCS DDDIEGPCFT VELCLSGDVR GGGSWDNRFN
INLAIDTNVK TTGRKRALFR MSNGSYQESV EMMFDATRKR CVQYTAAVIT AQGNRDRFSP
VTINVDFSLA STTDDNTTPV LDAIAPQSKS TTVTFKNDCG DNNICDVDLS ITGKLDYFGH
KSGWTSIVVD GTKELFVELS IKNSQETNYW TVVEIAVNLD LPFSRPTPST DPSITCQAVT
QDTDETGTMP VQESKVICNY YKPLKNGETV KVGVAFDTFE ISLEKKTLTV TAKVMPKNLE
TSKEIVPSDN TLELYTNVQI IADVTVNGVS SPAEMTVQDV KPISLDGKTN ILDAYKPKDV
EDLSLTHKFL VRNKGPSTLL PTKVRMSIPF YLTDASQFVN SFTVEMTSDS GDVSVCKSIK
NFDSFGRVIQ ATTGSPIRTT KKTVEDKTTT DATMTTTLEV KKTTNDYWFP GAEPRRRRST
LSRNRRSAAA LNSNIYIQSC KLDPVYCQVF ECDLSHGLKR DHYAEVNVSL VVNKLNIPVP
QSFNTFWYEV RAEVIQPKHE LMDDWQEEEG TGNSVTKFHL VESGGKINIW IIIGSIIGGL
ILITIVVIIL WRAGFFKRNK HQQVAQWKRE SQRRSRYSSV PQSDGGPQKE
//
