ID   A0A433SQ97_ELYCH        Unreviewed;       777 AA.
AC   A0A433SQ97;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   RecName: Full=Cullin-5 {ECO:0000256|ARBA:ARBA00040451};
GN   ORFNames=EGW08_020813 {ECO:0000313|EMBL:RUS71430.1};
OS   Elysia chlorotica (Eastern emerald elysia) (Sea slug).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Sacoglossa; Placobranchoidea;
OC   Plakobranchidae; Elysia.
OX   NCBI_TaxID=188477 {ECO:0000313|EMBL:RUS71430.1, ECO:0000313|Proteomes:UP000271974};
RN   [1] {ECO:0000313|EMBL:RUS71430.1, ECO:0000313|Proteomes:UP000271974}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EC2010 {ECO:0000313|EMBL:RUS71430.1};
RC   TISSUE=Whole organism of an adult {ECO:0000313|EMBL:RUS71430.1};
RA   Cai H., Li Q., Fang X., Li J., Curtis N.E., Altenburger A., Shibata T.,
RA   Feng M., Maeda T., Schwartz J.A., Shigenobu S., Lundholm N., Nishiyama T.,
RA   Yang H., Hasebe M., Li S., Pierce S.K., Wang J.;
RT   "A draft genome assembly of the solar-powered sea slug Elysia chlorotica.";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RUS71430.1}.
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DR   EMBL; RQTK01001213; RUS71430.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A433SQ97; -.
DR   STRING; 188477.A0A433SQ97; -.
DR   Proteomes; UP000271974; Unassembled WGS sequence.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF76; CULLIN-5; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000271974};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          404..638
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   777 AA;  90384 MW;  07E488194E70FB6C CRC64;
     MTMLGQQGQC NFVDKWPSME PTVLKLLRQE SVPKQEWHDL FSDVHSVCMW DEKEGPNLIY
     EALGKDILDF IKQAQSRVLQ HAEESALLRA YIAEWGKFFT QCSYLPKPFS QLEANLMGKL
     HSSMPKKLQS PDESLVRKLM LDKWNSSIFS NIKDKLQYSA MKLVHAERHG EAFDTQLVIG
     VRESYVNLSS DAEDKLKIYC ENFEKAYLEA AENFYKQNGP TYLQQNGVQN YMRYADTKLK
     EEEARAKRYL ETSYGCNSVN SLVECCVRAL VTSFKDTILA ECASMIKNNE TEKLRLMFSL
     MDRVPDGIQP MLQDLENHIV NQGLADMMSA AETITTDSEK YVEQLLELFN RFSLLVSEAF
     NDDPRFLTSR DKAYKTVVND TSVFKLEIPV KNKGPGAKSQ RESKCPELLA NFCDMLLRKT
     TISKRLMPEE VDKKLKNVLL VLKYVQSKDV FMRYHKAHLT RRLILESSAD NEKEENMVEW
     LRDVGMPADF VNKLQRMFQD IKVSDDLNHE FKEAHRNNNE GIADAVNIKI LNAGAWARSS
     ERMPVSLPLE LEDYIPQVEE FYKHKHSGRK LQWHHAMSNG VITFCNDVGR YELEVTTFQM
     AVLFAWNQRP REKLTYESLK LATELPDNEL RKTLMSLMTS KNKILLSSNE IKTLRDFEDN
     TEFWINQQFA FTKSGKVQKR GKTNLIGRLQ LTTEKSREED NEGIMQLRIL RVQEAIVKIM
     KMRKKLTNAA LQTELVEILK NMFLPSKKLI KEQIEWLIEH KYMRRDEDDI NTFIYMA
//