ID A0A433STT5_ELYCH Unreviewed; 1247 AA.
AC A0A433STT5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:RUS72700.1};
GN ORFNames=EGW08_019536 {ECO:0000313|EMBL:RUS72700.1};
OS Elysia chlorotica (Eastern emerald elysia) (Sea slug).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Sacoglossa; Placobranchoidea;
OC Plakobranchidae; Elysia.
OX NCBI_TaxID=188477 {ECO:0000313|EMBL:RUS72700.1, ECO:0000313|Proteomes:UP000271974};
RN [1] {ECO:0000313|EMBL:RUS72700.1, ECO:0000313|Proteomes:UP000271974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC2010 {ECO:0000313|EMBL:RUS72700.1};
RC TISSUE=Whole organism of an adult {ECO:0000313|EMBL:RUS72700.1};
RA Cai H., Li Q., Fang X., Li J., Curtis N.E., Altenburger A., Shibata T.,
RA Feng M., Maeda T., Schwartz J.A., Shigenobu S., Lundholm N., Nishiyama T.,
RA Yang H., Hasebe M., Li S., Pierce S.K., Wang J.;
RT "A draft genome assembly of the solar-powered sea slug Elysia chlorotica.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RUS72700.1}.
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DR EMBL; RQTK01001030; RUS72700.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A433STT5; -.
DR STRING; 188477.A0A433STT5; -.
DR Proteomes; UP000271974; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF195; POLYCYSTIC KIDNEY DISEASE 1 LIKE 2A-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000271974};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 83..287
FT /note="Polycystin"
FT /evidence="ECO:0000259|Pfam:PF20519"
FT DOMAIN 289..510
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 771..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 142..155
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 1247 AA; 140394 MW; 331BEBB40EB97666 CRC64;
MPAAQCLHSD TESDKDENNN NLEDSVNTRR RKNVKSLIWE AVFYSLLLTL LVCIAFDIRD
QRSYGFHSHI VAATDPKGKI GKMSTPKEMF DWARDYLAPF LYEITRWKNL TMGNSTRATA
SLATYKIGPT RIRQHRMPQQ GCESPSQLQP FRSRCIPSWS SSDLAWADYT TNWKLEHYTG
AYSDRPRSPW RYSRWAHVGG TPVAGRLGFY PIGGYVHDMS GTLEEVKANL TELENLHWVD
EWTKVVFIET TIYTANINMF ALITALFEFP QAMVLQAQLY THPFKLLTYT NDYPLSAQVF
DILIFFAVGW FILRVAYKLY RWRWDFFGKF WHIVELSNLL LAIAVIVLYV GRDKVADKVA
DESNMTSGQF YNFQTLSMWD QLFGILLGFC CFLSTLKVLH LFRFNRRMSL LGKTLKLSAG
DLIGFFVLYI LLMMAFVCFS FLVFHNYLYS YSTIMGTIES LLLLALGDLQ YKKITSANRV
IAPVLITAYT ALIMFILLNV LVSILMDAFA AAREAIKNQP NDFELLMCMT KSLNKAVVSP
LHTAWDFACK ADMDSPRKSD GGSGNGYGMA IPAEKGRKGI LALSNKQRNP RFSRAVRFSS
GFITDSPRKP VRYSTPKARK SLTRQSFLDS PPVSSIAIKS SLKKRLSTSV NSIEENTGLF
LQQLDLIDRR LDSLWLGFVG GESGPPPEVP AIQRCTEVKV TVADVVSRRL GFQDDSGSSS
SSYQDGEDEV EDEPGVVINN SDDSESVSEM SIELHQSENN TIIEVHVEHH IHPSDNDNDK
KETAEEKSET LSEEMVISSY DRVDDIQENI DKLVPFEDLK NDEMVVESQE KVVPHSIVEN
RRSDEALNIT EESPGIIVSQ HDENSHGASQ AENEELVADE TNDGGVQLDN KTTQYDIESP
LDIEEARAAY EDDHSDNIND INSETQEAPH VDGDLGIAEV SAASDIRHED CLSFQTKDRL
NESEYEIVDE KEPYADVGSK IKEDAKTAYE NDHSNTINDI KSETQEAPQV DGDMGIVEVL
ETSDIHPDDS LSFQTKERLN EPEYEIVDET ESHPKPSSLY AERHRIKVAS KYQRVSSEPN
FKSLVPFVIE RSTVKQMSGE YDKMCYRRQL DPLQRLNIGA EGALISTPTS RSFACFPDFF
NDSGYQSPGD LDKTIEASPG YQSAVDRGQD MEASSSEEQV NATLNLGGDS ITDLEAASKD
VEMLQPLDSH IEEAPKGCNI GLQTSPLCRV KLTSALKVRF VIGDEKE
//
