ID A0A433T7I3_ELYCH Unreviewed; 333 AA.
AC A0A433T7I3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 13-SEP-2023, entry version 13.
DE RecName: Full=Cytokine-inducible SH2-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=EGW08_014725 {ECO:0000313|EMBL:RUS77513.1};
OS Elysia chlorotica (Eastern emerald elysia) (Sea slug).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Sacoglossa; Placobranchoidea;
OC Plakobranchidae; Elysia.
OX NCBI_TaxID=188477 {ECO:0000313|EMBL:RUS77513.1, ECO:0000313|Proteomes:UP000271974};
RN [1] {ECO:0000313|EMBL:RUS77513.1, ECO:0000313|Proteomes:UP000271974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC2010 {ECO:0000313|EMBL:RUS77513.1};
RC TISSUE=Whole organism of an adult {ECO:0000313|EMBL:RUS77513.1};
RA Cai H., Li Q., Fang X., Li J., Curtis N.E., Altenburger A., Shibata T.,
RA Feng M., Maeda T., Schwartz J.A., Shigenobu S., Lundholm N., Nishiyama T.,
RA Yang H., Hasebe M., Li S., Pierce S.K., Wang J.;
RT "A draft genome assembly of the solar-powered sea slug Elysia chlorotica.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RUS77513.1}.
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DR EMBL; RQTK01000575; RUS77513.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A433T7I3; -.
DR STRING; 188477.A0A433T7I3; -.
DR Proteomes; UP000271974; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR CDD; cd09923; SH2_SOCS_family; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF16; SH2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000271974};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 172..253
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 279..332
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 333 AA; 38122 MW; 50F8DEA4BBECCDF0 CRC64;
MTLLNRECVE EDQPTIELFS TTSKSTILPQ HLQLFSNLTC GRTHCARITS QLENFPVLHQ
TPVVQIQLSS QLVRKLLLVN ERRQSIMCHN SKQTSVLGGE LDLPSQSWER NFLAVVGQHT
EDDDDEDRPR QDSGFSSGGI SLSLGYYKPL QRCMDDFEKL NVVMDELDES HFYWGDMDSD
TARRRLRSAP VGTFLVRASS DSRFLYSLSV KTERGATSVR ILYEGGLFQF DCDSSIRDQL
PRFESVLALV DFYVLLSQEG GNRLWRWEEV SGDKHMKMTL LQPLRSSVPS LAHQARVKVN
QCLENVFFPN LSVDKLNIPD KMKAFLRAYP YRS
//
