ID A0A433TL97_ELYCH Unreviewed; 1776 AA.
AC A0A433TL97;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=EGW08_009895 {ECO:0000313|EMBL:RUS82342.1};
OS Elysia chlorotica (Eastern emerald elysia) (Sea slug).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Sacoglossa; Placobranchoidea;
OC Plakobranchidae; Elysia.
OX NCBI_TaxID=188477 {ECO:0000313|EMBL:RUS82342.1, ECO:0000313|Proteomes:UP000271974};
RN [1] {ECO:0000313|EMBL:RUS82342.1, ECO:0000313|Proteomes:UP000271974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC2010 {ECO:0000313|EMBL:RUS82342.1};
RC TISSUE=Whole organism of an adult {ECO:0000313|EMBL:RUS82342.1};
RA Cai H., Li Q., Fang X., Li J., Curtis N.E., Altenburger A., Shibata T.,
RA Feng M., Maeda T., Schwartz J.A., Shigenobu S., Lundholm N., Nishiyama T.,
RA Yang H., Hasebe M., Li S., Pierce S.K., Wang J.;
RT "A draft genome assembly of the solar-powered sea slug Elysia chlorotica.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RUS82342.1}.
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DR EMBL; RQTK01000290; RUS82342.1; -; Genomic_DNA.
DR STRING; 188477.A0A433TL97; -.
DR Proteomes; UP000271974; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13240; PH1_Kalirin_Trio_like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd00176; SPEC; 4.
DR Gene3D; 1.20.58.60; -; 5.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047054; Kalirin_TRIO_PH_1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR22826:SF210; CRAL-TRIO DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00435; Spectrin; 5.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 7.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 6.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000271974};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 49..180
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 1248..1423
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1435..1547
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1626..1694
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1208..1242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1210..1242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1776
FT /evidence="ECO:0000313|EMBL:RUS82342.1"
SQ SEQUENCE 1776 AA; 203211 MW; C822B3CA5D763B0D CRC64;
MSSGDQGAEG GAEKDVEYYY RPGGRRNDGL KAADIVHVLR ERVAYLSGGR DRRGGPILTF
PSHTHPERLK HEDLRRLMTY LASVPSDEVR DRGFTMILDM RGTKWETVKP VLKALQECFP
GNINMAFIIK PEKFWEKQRT SLGSSKYNFE TNMISLDSLN KAIEPTQLTR EFDGTLEYDH
EQWIQLRLML EEFIWKALDL LDKLGALGEI LTNPELPDDL NGAQMVLEEH NQLKKRVTMA
PVEQLAMEGH HILQRITGEY IGSGGRRYVI SGNADFQSAV PQISQLLDNL QSTKQHLNQL
WSVKKMRLEQ CFQLRIFEED VEKMFEWISH NRDLFLVNYT EIGTCHQMAV ELESEHCQFA
TSAENVYVNI ERILGMAQRM CDSGHYASNT IRMEGGKLER EWKSLAAALE DRSTVLRMSV
VFHKKAEQYL AQVIVWQNTC ESIKIPSGIE DLEDALQQHQ TLIETISQTY AEVCGDGKAL
LDTLQTPVTS SSANSITAKA DYSEAAGHVL DVVHEVLAHQ RHLEQIWHGK KVKLHQRLGL
RLFQQDVKQV IDWLNNHGDV FLKKNISIGK SLQRAKALQK SHEHFESVAR NTITNAEKLL
AAADELAQTG ECDATEIYSE ARELEQRMHQ FLSSLQRRRN VLDMTVIFYS HVHELTNWLE
NLHTELQSTE LANSVEGAEQ LMAQFNQQRE TTVEAAINTV GEGETLLEQL RLISMETEKT
GHSADYKHIE GVLTQLNESR SQLEDLWGAR KMKLDLCLQM QVFERDSMEV SSQLELLSEE
LQHMEMVTDG GKAEQLLQIH NESVMHVQNC TFEVLQRGQE LAQVMSEHDH DALTRITALL
EFLNDRQVDL EGLAEQKRVR LQQCVHLRNF EIEARQVILW VRNGETMLTD SFMCPNTLVE
AEQLQKEHEQ FMLAIEKTHF SVVTVTQRAE AMLQQQHYNG ELVRAIAENV TLAWQQLMYH
AEERQKLVMA STNWYKTAEQ VWSVLESLDR EYKRDEDWCN SEKAGTANIQ AKAAYLVQLI
NKHNEQKEAF LKACTLARRT AETFLKYVTR NLHFLGMQMK FRSPEQRVKG TLAKLLQQEN
LVREFWTMKK RKLEQCHQFV LFEQSAKQAL EWIHEYGEAY LASHTNLGVD KNETEALLKE
HYEFRNRAKE TKENVKLLLQ LADDFVTKGN IHASSILEWC SMVDKRYKLF SQRMEKYRLQ
LQAKLGVAPQ EQSEKDEQRQ SDSSIEEKLE QTGTAKELTE EKRKSARRRE FIMAELLQTE
RTYVKDLETC INCYMKPMSA GSINVPAGIQ GKEHVVFSNM DEIHEFHKDV FLKELEKYET
IPEDVGHCFV TWAVKFSIYV NYCKNKPDSN ALLVEQAGSF FEEMQHKSKL NEPIASYLIK
PVQRVTKYQL LLKDLLTCCE EHTGEIKEAL EVMMNVPKRA NDAMHLSMLE GVEENLAEYG
DVLLQDNFTV WDPKQLIKKG RDRHLFLFDV CLIFSKEVKD SNGKSKYIFK FKLMIAEINV
TEHIEGDETK FALWTGRAPI SDYRIILKAS SLDTKQQWVK KLRELIQERV MYLNDALKDK
QATMFKQPPK LFNPSRVSRE MEEGSTVEGL TALERRGSLM SIASTTTTGT NDSSNSGSTQ
ISRTGLPYLT TAVLEDYSAT SSKEVSVQRG TQVEVVEPSP PGFPDWCLVR TLPPDGADSS
QGLVPTGVLR PVSLLSGGRN SIDGDDTFVS ADGTSSPVSK RRSSFKKWLT TPVRKLSHGK
IEKAGGMLLD PQRALQRKHN MLGAAHQVGP GNGAWG
//
