ID   A0A433TN51_ELYCH        Unreviewed;       786 AA.
AC   A0A433TN51;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   RecName: Full=VWFD domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=EGW08_009298 {ECO:0000313|EMBL:RUS82961.1};
OS   Elysia chlorotica (Eastern emerald elysia) (Sea slug).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Panpulmonata; Sacoglossa; Placobranchoidea;
OC   Plakobranchidae; Elysia.
OX   NCBI_TaxID=188477 {ECO:0000313|EMBL:RUS82961.1, ECO:0000313|Proteomes:UP000271974};
RN   [1] {ECO:0000313|EMBL:RUS82961.1, ECO:0000313|Proteomes:UP000271974}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EC2010 {ECO:0000313|EMBL:RUS82961.1};
RC   TISSUE=Whole organism of an adult {ECO:0000313|EMBL:RUS82961.1};
RA   Cai H., Li Q., Fang X., Li J., Curtis N.E., Altenburger A., Shibata T.,
RA   Feng M., Maeda T., Schwartz J.A., Shigenobu S., Lundholm N., Nishiyama T.,
RA   Yang H., Hasebe M., Li S., Pierce S.K., Wang J.;
RT   "A draft genome assembly of the solar-powered sea slug Elysia chlorotica.";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RUS82961.1}.
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DR   EMBL; RQTK01000264; RUS82961.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A433TN51; -.
DR   STRING; 188477.A0A433TN51; -.
DR   Proteomes; UP000271974; Unassembled WGS sequence.
DR   Gene3D; 2.10.25.10; Laminin; 1.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR   PANTHER; PTHR11339:SF398; MUCIN-2-LIKE-RELATED; 1.
DR   Pfam; PF08742; C8; 1.
DR   Pfam; PF00094; VWD; 2.
DR   SMART; SM00832; C8; 1.
DR   SMART; SM00216; VWD; 2.
DR   SUPFAM; SSF57567; Serine protease inhibitors; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS51233; VWFD; 2.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Reference proteome {ECO:0000313|Proteomes:UP000271974};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..786
FT                   /note="VWFD domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5019451168"
FT   DOMAIN          106..144
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          223..423
FT                   /note="VWFD"
FT                   /evidence="ECO:0000259|PROSITE:PS51233"
FT   DOMAIN          599..772
FT                   /note="VWFD"
FT                   /evidence="ECO:0000259|PROSITE:PS51233"
FT   DISULFID        134..143
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   786 AA;  84679 MW;  11B9D90EAAD0DC76 CRC64;
     MGVSVPLLSK TLLLLLVWLV NFQSVQSLLR IDRSHFCNAR TGKKVYEDHL CADLMDLLTV
     KGLHFERFKA ESAPTFKDTG AVCTFSRLEA SSGKDCCRGW AGVNCDIAVC EPSCQHGKCV
     DTGKSITAPP ECQCDPLYKG KGCEEETSQL TEELRFCYAG GDCHGTILGG GVAMPITRCC
     EDLGGTTWGS QDQSHGCTPC SPGSPECILK DGVVESVASG GTATCMASGD IYRTLDGVVF
     KYHSVCAVGM LITDALRIYT VSRCDPVDRS TCSKDVIIEI EATTYTLTST TLTVHDGSDS
     ISFDISKLVH NRPTAVNNKG TVNLKYDALQ ETTSVSIEAF DVIVQVDADG TFILVVREDS
     PLKASVQGVC GNMDGDYADE LALQTAVGAQ KVFEKFKKDS IACGSSVQTC PPNLEDDANE
     ACSALSTAFT ECHKAVTIND YLERCRSYYC ASMTAPGGGP QAAQKAVCNV LSSYNKVCTM
     ITGTATMWRT PQLCPKNCPA PYVFTSRMRK CPIMCGLSPM SYTRSECYSS MRFSGCDCPL
     GMARLNDTCV APTDCQCVAD NGKFYSKGAA IVSGDHCQSC ICGEYGLWQC TPSPDRCSAT
     CSINQGRLVK TFDGKLYAIG NSCGTLQLAK SPEIDIQMET STCTQSGNGV HVCPTFISVT
     YRGKTSTLDI SVEGVSIVNG YSPNVYIRQV SRHIYVVDVR GGNARIFVNL DGTVHLKMKT
     SLYKNKLVGL CGNMDGNKDN DFTTYSQASV NGQAFLEVFT SCPTVTYTEL SPVPMNPLCH
     VEDRRG
//