ID A0A433TVE4_ELYCH Unreviewed; 731 AA.
AC A0A433TVE4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 13-SEP-2023, entry version 18.
DE RecName: Full=VHS domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=EGW08_006650 {ECO:0000313|EMBL:RUS85567.1};
OS Elysia chlorotica (Eastern emerald elysia) (Sea slug).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Sacoglossa; Placobranchoidea;
OC Plakobranchidae; Elysia.
OX NCBI_TaxID=188477 {ECO:0000313|EMBL:RUS85567.1, ECO:0000313|Proteomes:UP000271974};
RN [1] {ECO:0000313|EMBL:RUS85567.1, ECO:0000313|Proteomes:UP000271974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC2010 {ECO:0000313|EMBL:RUS85567.1};
RC TISSUE=Whole organism of an adult {ECO:0000313|EMBL:RUS85567.1};
RA Cai H., Li Q., Fang X., Li J., Curtis N.E., Altenburger A., Shibata T.,
RA Feng M., Maeda T., Schwartz J.A., Shigenobu S., Lundholm N., Nishiyama T.,
RA Yang H., Hasebe M., Li S., Pierce S.K., Wang J.;
RT "A draft genome assembly of the solar-powered sea slug Elysia chlorotica.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004150}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GGA protein family.
CC {ECO:0000256|ARBA:ARBA00008099}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RUS85567.1}.
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DR EMBL; RQTK01000165; RUS85567.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A433TVE4; -.
DR STRING; 188477.A0A433TVE4; -.
DR Proteomes; UP000271974; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14234; GAT_GGA_meta; 1.
DR CDD; cd03567; VHS_GGA_metazoan; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR027422; GGA1-3.
DR InterPro; IPR041198; GGA_N-GAT.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45905; GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN; 1.
DR PANTHER; PTHR45905:SF1; GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF18308; GGA_N-GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000271974};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 14..144
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 168..296
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT DOMAIN 610..729
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 526..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:RUS85567.1"
SQ SEQUENCE 731 AA; 78992 MW; ED274CBAFBC36DEC CRC64;
ATSDDSLENL LNKATDPAQK EADADRITAF CDKVNAELEG PLLSTRLLAH KIQSPQEKEA
LYALITLESC VKNCGRYFHQ EIGKFRFLNE LIKVVSPKYL GNRTPMAVKK RCIEIMYSWH
KGLGHEPKIA EAYKMLKAQG IVKQDPVYMD RTFDPFPPPK PRKADFEDDE KAKTLEKLLR
SKNPDDLQAA NRLIKNMVKE DAEKSERKSR RINELEAVGN QVKLLTEMIS QYSSSATSKE
ELEMMKELYE SLEKARPSLF RLASDTDEND TDGINDILHA NDAVTRVMTL YKEKVEGEKP
AGDYTAGAKD TSLLDDLGFD SSARSNAPAS TEISGSGLLE NDFRSFGLGD MSELGSVFNN
LPTATSQQQQ FSGMAGLATP AGMGMVNFGA QSAFRGMPSM QPAATSSMSF PAGMPPAYSA
ISHNVRPMAP STAAPALIPS AVGQPAFSTS NGVHPAASQS QPIVSVFSQS STANGTGGNS
SSSLSDLDIL DKSLQDYKLS KESFPVKTMY KERNVPAKLP MNQLAANKAA AATSEAPPPL
KTGQPLVPAS FLTPQPTSSA PSTAAPPAQA QVTSTDPAET DFSFVSAAPE PELLPLTDVF
VPLEKIQPAP NIPSVQAYEK NGLKVMVHFA ADRPRPDVVT MVVSTMSTNP SSVSSFVFQA
AVPKIMKVKL QPPSASEFPA YNPILPPAAI TQVMLVANPR KEKVRLKYKL SYSIGGEQFS
DVGDIDGIPV Q
//
