ID A0A433U5V7_ELYCH Unreviewed; 1709 AA.
AC A0A433U5V7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
DE Flags: Fragment;
GN ORFNames=EGW08_003032 {ECO:0000313|EMBL:RUS89222.1};
OS Elysia chlorotica (Eastern emerald elysia) (Sea slug).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Sacoglossa; Placobranchoidea;
OC Plakobranchidae; Elysia.
OX NCBI_TaxID=188477 {ECO:0000313|EMBL:RUS89222.1, ECO:0000313|Proteomes:UP000271974};
RN [1] {ECO:0000313|EMBL:RUS89222.1, ECO:0000313|Proteomes:UP000271974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC2010 {ECO:0000313|EMBL:RUS89222.1};
RC TISSUE=Whole organism of an adult {ECO:0000313|EMBL:RUS89222.1};
RA Cai H., Li Q., Fang X., Li J., Curtis N.E., Altenburger A., Shibata T.,
RA Feng M., Maeda T., Schwartz J.A., Shigenobu S., Lundholm N., Nishiyama T.,
RA Yang H., Hasebe M., Li S., Pierce S.K., Wang J.;
RT "A draft genome assembly of the solar-powered sea slug Elysia chlorotica.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RUS89222.1}.
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DR EMBL; RQTK01000062; RUS89222.1; -; Genomic_DNA.
DR STRING; 188477.A0A433U5V7; -.
DR Proteomes; UP000271974; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 6.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 6.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR46513:SF13; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4-LIKE PROTEIN; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 5.
DR Pfam; PF00057; Ldl_recept_a; 6.
DR Pfam; PF00058; Ldl_recept_b; 13.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00192; LDLa; 6.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 6.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 6.
DR PROSITE; PS51120; LDLRB; 15.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000271974};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1578..1599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 313..352
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 398..440
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 441..483
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 484..527
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 528..570
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 673..715
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 716..758
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 759..802
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 803..845
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 980..1022
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1023..1065
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1066..1109
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1110..1151
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1330..1372
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1373..1416
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1418..1459
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 1..13
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 8..26
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 20..35
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 40..52
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 47..65
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 78..90
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 85..103
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 97..112
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 158..170
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 165..183
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 177..192
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 197..209
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 204..222
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 216..231
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 236..248
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 243..261
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 255..270
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 317..327
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:RUS89222.1"
SQ SEQUENCE 1709 AA; 191325 MW; 7829A1EF9E5CB69D CRC64;
CPESQFTCRN GDCIKASWVC DGDHDCVDMS DELNCPKRNC SEGEMSCANG HCVPLEWRCD
GHDDCNDGSD EPCSNQECRA DELRCPGGLC LPMAQRCDGN FDCSDGTDEI DCGQLFVLIR
KRGRGKGRFG SFFVTMAQRC DDNFDCSDGT DEMNCGGCQK GEFRCSSGLC INRRWHCDGD
FDCPDRSDEL NCTLRACGSD EFRCTTGVCI ARALHCNSNQ DCSDNSDEEG CRPKRCRQDQ
FSCDRGKCLD LHTVCDGQTD CKDGADEINC NFPGTCQDNN GWCHHNCQDT SLGARCWCRP
GYLLHQDKKS CTDVDECVYQ GVCSQICRNT DGSYKCACVP GYKLKSDGKG CKAQGGEAYL
IFANRVDIVT VTTNKDDFTS ILQGLQDAIA LDFHHRRGYV FWSDVTLDVI KRAHLNGTHV
MDIVSEGLDN PGGLAVDWVH DKLFWTDSGT ARIEVSNLDG SFRKVVLWQN LEKPRAIAAF
PEKGLIFWTD WGKTPKIERA SMDGSLRMVL ANTSLFWPNG LTLDYAAERI YWADAKHHVI
ESSSLEGLQR RTVISQGLPH PFALTIFEDE LFWTDWETKS INKANKFSGN GVETIHSRLF
FPMDIHTMHP QRQPPATSKC GPRNGGCSHL CLPHESGYTC ACPTGLMLGQ DRQTCAEGCV
HVSSEIEFDS ATDSIFWSDI GSDNIGSASW DGQNQAILVG SSLDSPAGIA LDWAGRNLYW
TDSGNDRIEV ITLDTKLRTV IIWNGLDHPR DIVVHPLKGY MFWTDLGKSA AIERAGMDGS
QREVIVGHNT TWPNGLAIDH TDDRLYWVDA GTHALESCSM DGKDRRVIVA SGLQHPFGAT
VFGSLVYWTD WDTGSIHYAD KDTGLGQGHL DLNFGHILDL KIFHRHRAAV PTPCTDNNGG
CSHICLLAPA PKGHTCACPT GLLMEPDGVT CQTEMRNFLI FTRGKDIRKI SLEVDYYMDV
VVPVGEVRNA IAIDVDVIEG KMYWTDTVLD RISRANLDGS DVEILVEHGV HTTDGLAVDS
VGRKIYWTDD GHNRIEVSNL DGSMRTVLLY EYLDKPRAIA LHYDKGYMFW TDWGKLARIE
RADMDGKNRV TIVSKDIVWP NGLTIDLAMD RIIWADARTE RIECADMSGK FRRGLVSRVQ
HPYGLTVAGN SIFWTDWRQR SIYQANKNMA SNITKLRSNL KGVMDIHAVH IGGVETHVNR
CGQNNGGCSH LCLPNPSGVS CACPTEIVTT TYKNSSYHPE PSKYLLFAAR GSIRRISLDT
PDHTDAYLPI PGLHNVIALD FDYRDNMVYY TDVDLDVVRR AYLNGSVWTE DIILKELATT
DGLAVDWIAR NLYWTDAGRD VIEVSRLDGS CRKKIIEKHL SEPRAIALYP KKGLMFWTDW
GTNPRIERAY MDGTTRKVII NRELGYPNGL TIDYSAEPRL YWGDAKLDKI ETADLAGRDR
HTLVQRTPHP FGLTVFEDRI YWTDWQTERL ETARKLDGLG RMTIQSRLEG LMDVHMVTPQ
RQTGGNNCSS NNGGCSHLCL ARPDGYVCAC PDEQDSRACQ TSTLFCRYFE KCMPYLAKLV
RCFVIILKNE EEVNSGPYIA IATIMAVLLV ILIIAFFIWK RHRRRHYNVE EFSTLTYANP
TYQKASTETI NTDNRTSKGH FRYHSSDERL TSGGMGSDEG SQHEAVLLVQ PSPQSTSDRP
RSLPRLMWTP DSEEAEWGGT AGVYRPVMT
//
