ID A0A437AMR5_9MICR Unreviewed; 142 AA.
AC A0A437AMR5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Protein AF-9 homolog {ECO:0000256|ARBA:ARBA00022408, ECO:0000256|RuleBase:RU367117};
GN Name=YAF9 {ECO:0000256|RuleBase:RU367117};
GN ORFNames=TUBRATIS_009900 {ECO:0000313|EMBL:RVD92502.1}, TUBRATIS_11840
GN {ECO:0000313|EMBL:RVD92317.1};
OS Tubulinosema ratisbonensis.
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Tubulinosematoidea;
OC Tubulinosematidae; Tubulinosema.
OX NCBI_TaxID=291195 {ECO:0000313|EMBL:RVD92317.1, ECO:0000313|Proteomes:UP000282876};
RN [1] {ECO:0000313|EMBL:RVD92317.1, ECO:0000313|Proteomes:UP000282876}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Franzen {ECO:0000313|EMBL:RVD92317.1,
RC ECO:0000313|Proteomes:UP000282876};
RA Polonais V., Peyretaillade E., Niehus S., Wawrzyniak I., Franchet A.,
RA Gaspin C., Reichstadt M., Belser C., Labadie K., Delbac F., Ferrandon D.;
RT "Draft genome sequence of the microsporidian Tubulinosema ratisbonensis.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC dependent exchange of histone H2A for an H2A variant leading to
CC transcriptional regulation of selected genes by chromatin remodeling.
CC Component of the NuA4 histone acetyltransferase complex which is
CC involved in transcriptional activation of selected genes principally by
CC acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. Yaf9 may also be required for viability in
CC conditions in which the structural integrity of the spindle is
CC compromised. {ECO:0000256|RuleBase:RU367117}.
CC -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC transcriptional regulation of selected genes by chromatin remodeling.
CC Component of the NuA4 histone acetyltransferase complex which is
CC involved in transcriptional activation of selected genes principally by
CC acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. Yaf9 may also be required for viability in
CC conditions in which the structural integrity of the spindle is
CC compromised. {ECO:0000256|ARBA:ARBA00025636}.
CC -!- SUBUNIT: Component of the SWR1 chromatin-remodeling complex and of the
CC NuA4 histone acetyltransferase complex. {ECO:0000256|ARBA:ARBA00038745,
CC ECO:0000256|RuleBase:RU367117}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367117}.
CC Cytoplasm {ECO:0000256|RuleBase:RU367117}.
CC -!- DOMAIN: The coiled-coil domain is required for assembly into the NuA4
CC complex. {ECO:0000256|RuleBase:RU367117}.
CC -!- SIMILARITY: Belongs to the YAF9 family. {ECO:0000256|ARBA:ARBA00038419,
CC ECO:0000256|RuleBase:RU367117}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RVD92317.1}.
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DR EMBL; RCSS01000249; RVD92317.1; -; Genomic_DNA.
DR EMBL; RCSS01000200; RVD92502.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A437AMR5; -.
DR STRING; 291195.A0A437AMR5; -.
DR VEuPathDB; MicrosporidiaDB:TUBRATIS_009900; -.
DR VEuPathDB; MicrosporidiaDB:TUBRATIS_11840; -.
DR Proteomes; UP000282876; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd16887; YEATS; 1.
DR Gene3D; 2.60.40.1970; YEATS domain; 1.
DR InterPro; IPR038704; YEAST_sf.
DR InterPro; IPR005033; YEATS.
DR PANTHER; PTHR23195; YEATS DOMAIN; 1.
DR PANTHER; PTHR23195:SF15; YEATS DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF03366; YEATS; 1.
DR PROSITE; PS51037; YEATS; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU367117};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU367117};
KW Coiled coil {ECO:0000256|RuleBase:RU367117};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU367117};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU367117};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU367117};
KW Initiation factor {ECO:0000313|EMBL:RVD92317.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00376}; Protein biosynthesis {ECO:0000313|EMBL:RVD92317.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000282876};
KW Transcription {ECO:0000256|RuleBase:RU367117};
KW Transcription regulation {ECO:0000256|RuleBase:RU367117}.
SQ SEQUENCE 142 AA; 16664 MW; A06222301E107812 CRC64;
MYTSKRIWIG NTARLIPLEE RIHPDLTHSW TVYVKAHDPS FITSVTFKLH ESFINNIVET
TYPFEVSQSG WGEFTVHIKI STKLGNVHTT HALLIHNVEK SERMDEIIFK GNEKENHLIT
KEEEDEFYKI ENAIEKILQK LE
//
