ID A0A437C9N1_ORYJA Unreviewed; 444 AA.
AC A0A437C9N1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 22-FEB-2023, entry version 14.
DE RecName: Full=Gap junction protein {ECO:0000256|RuleBase:RU000630};
GN ORFNames=OJAV_G00188780 {ECO:0000313|EMBL:RVE59476.1};
OS Oryzias javanicus (Javanese ricefish) (Aplocheilus javanicus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=123683 {ECO:0000313|EMBL:RVE59476.1, ECO:0000313|Proteomes:UP000283210};
RN [1] {ECO:0000313|EMBL:RVE59476.1, ECO:0000313|Proteomes:UP000283210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS831 {ECO:0000313|EMBL:RVE59476.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:RVE59476.1};
RA Lopez-Roques C., Donnadieu C., Bouchez O., Klopp C., Cabau C., Zahm M.;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:RVE59476.1, ECO:0000313|Proteomes:UP000283210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS831 {ECO:0000313|EMBL:RVE59476.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:RVE59476.1};
RA Herpin A., Takehana Y., Naruse K., Ansai S., Kawaguchi M.;
RT "A chromosome length genome reference of the Java medaka (oryzias
RT javanicus).";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell.
CC {ECO:0000256|RuleBase:RU000630}.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC {ECO:0000256|RuleBase:RU000630}.
CC -!- SUBCELLULAR LOCATION: Cell junction, gap junction
CC {ECO:0000256|ARBA:ARBA00004610}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU000630}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the connexin family.
CC {ECO:0000256|RuleBase:RU000630}.
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DR EMBL; CM012455; RVE59476.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A437C9N1; -.
DR Proteomes; UP000283210; Chromosome 19.
DR GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; CONNEXIN; 1.
DR PANTHER; PTHR11984:SF6; GAP JUNCTION GAMMA-1 PROTEIN; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868,
KW ECO:0000256|RuleBase:RU000630};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000283210};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000630};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..73
FT /note="Connexin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00037"
FT DOMAIN 196..262
FT /note="Gap junction protein cysteine-rich"
FT /evidence="ECO:0000259|SMART:SM01089"
FT REGION 392..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 444 AA; 49460 MW; 4A4A4CA45A4E6963 CRC64;
MLKRGRTGGE IHNHSTFVGK IWLTVLIVFR IVLTAVGGES IYYDEQSKFV CNSGQPGCEN
VCYDAFAPLS HVRFWVFQII LVATPSLMYL GYAVNKIARA EERADGGGAG GCSQRKLKRP
YLAGRRQHRG VEEAEDDNEE DPMIYEVTEM ESDAGAAKGD GERHVKAKAR HDGRQRIKED
GLMRIYVLQL LARSLLELAF LCGQYALYGF AVPSSYVCSD LPCPHSVDCF VSRPTEKTIF
LLIMYSVSLL CLLLNVWEML HLGIGTICEI VQSRQLPLPH NELYKLTKKN GALNEGEAYG
GYPFTWNAPS APPGYSVDIK SLLVAKENQH LPISDLTNAK MACRQNHVNI AQEERREYAN
NEENLCKAGR GNGVRNGPKE PQIKLKADNQ VLSQQQNHSN NQSKPNRERR HRPASRHAAS
KAGTDISSTG SSSKYGMMKG SEWI
//