ID A0A437J4G1_9SPHN Unreviewed; 323 AA.
AC A0A437J4G1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 03-MAY-2023, entry version 10.
DE RecName: Full=thymidine phosphorylase {ECO:0000256|ARBA:ARBA00011892};
DE EC=2.4.2.4 {ECO:0000256|ARBA:ARBA00011892};
GN ORFNames=ENE74_14370 {ECO:0000313|EMBL:RVT39550.1};
OS Sphingobium algorifonticola.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingobium.
OX NCBI_TaxID=2008318 {ECO:0000313|EMBL:RVT39550.1, ECO:0000313|Proteomes:UP000282977};
RN [1] {ECO:0000313|EMBL:RVT39550.1, ECO:0000313|Proteomes:UP000282977}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TLA-22 {ECO:0000313|EMBL:RVT39550.1,
RC ECO:0000313|Proteomes:UP000282977};
RA Chen W.-M.;
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate +
CC thymine; Xref=Rhea:RHEA:16037, ChEBI:CHEBI:17748, ChEBI:CHEBI:17821,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000749};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RVT39550.1}.
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DR EMBL; RZUL01000006; RVT39550.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A437J4G1; -.
DR OrthoDB; 341217at2; -.
DR Proteomes; UP000282977; Unassembled WGS sequence.
DR GO; GO:0004645; F:1,4-alpha-oligoglucan phosphorylase activity; IEA:InterPro.
DR GO; GO:0009032; F:thymidine phosphorylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro.
DR GO; GO:0006213; P:pyrimidine nucleoside metabolic process; IEA:InterPro.
DR Gene3D; 3.40.1030.10; Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain; 1.
DR Gene3D; 3.90.1170.30; Pyrimidine nucleoside phosphorylase-like, C-terminal domain; 1.
DR InterPro; IPR000312; Glycosyl_Trfase_fam3.
DR InterPro; IPR035902; Nuc_phospho_transferase.
DR InterPro; IPR036566; PYNP-like_C_sf.
DR InterPro; IPR013102; PYNP_C.
DR InterPro; IPR017872; Pyrmidine_PPase_CS.
DR InterPro; IPR000053; Thymidine/pyrmidine_PPase.
DR PANTHER; PTHR10515; THYMIDINE PHOSPHORYLASE; 1.
DR PANTHER; PTHR10515:SF0; THYMIDINE PHOSPHORYLASE; 1.
DR Pfam; PF00591; Glycos_transf_3; 1.
DR Pfam; PF07831; PYNP_C; 1.
DR SMART; SM00941; PYNP_C; 1.
DR SUPFAM; SSF52418; Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain; 1.
DR SUPFAM; SSF54680; Pyrimidine nucleoside phosphorylase C-terminal domain; 1.
DR PROSITE; PS00647; THYMID_PHOSPHORYLASE; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000313|EMBL:RVT39550.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000282977};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:RVT39550.1}.
FT DOMAIN 253..320
FT /note="Pyrimidine nucleoside phosphorylase C-terminal"
FT /evidence="ECO:0000259|SMART:SM00941"
SQ SEQUENCE 323 AA; 33079 MW; E546872250CA2D5F CRC64;
MPPSAGTDPI IVAIVTACGL IMPKTSSRAI TSPAGTADAM ETLAPVDLDV AQMQKVVAAE
GGCVAWGGTV RLSPADDIFI GVERALDIDT EGQLVASVLS KKIAAGASHV VIDIPVGPTA
KVRSNAAADK LAARLAAIAA RFDIHVECIQ TDGTQPVGRG VGPALEAFDV LAVLQCLPDA
PADLKDRACL LAGTILELGG AAAPGAGRAL AECALARGDA WRKFEKIRAA QGGAREPPRA
ALTRDIAARH SGRVTHIDNR RIGRLAKLAG APDRPAAGLR LAVRLGDDIA AGQPLLRLHA
DSQGEMAYAL AYAEANSDMI AIA
//
