ID A0A437MPL5_9PROT Unreviewed; 858 AA.
AC A0A437MPL5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982};
GN Name=mutS {ECO:0000313|EMBL:RVT99582.1};
GN ORFNames=EOD42_05745 {ECO:0000313|EMBL:RVT99582.1};
OS Rhodovarius crocodyli.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae; Rhodovarius.
OX NCBI_TaxID=1979269 {ECO:0000313|EMBL:RVT99582.1, ECO:0000313|Proteomes:UP000282957};
RN [1] {ECO:0000313|EMBL:RVT99582.1, ECO:0000313|Proteomes:UP000282957}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCP-6 {ECO:0000313|EMBL:RVT99582.1,
RC ECO:0000313|Proteomes:UP000282957};
RA Chen W.-M.;
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RVT99582.1}.
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DR EMBL; SACL01000001; RVT99582.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A437MPL5; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000282957; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756};
KW Reference proteome {ECO:0000313|Proteomes:UP000282957}.
FT DOMAIN 690..706
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 858 AA; 91906 MW; 9E75FDBFE14DAB3B CRC64;
MHPNRPPADG ATPAMAQWYA AKAAHPDALL FFRMGDFYEL FFDDAEAAAE ALSIALTYRG
EHQGVPISMC GVPHHSHEAY LARLIRRGFR VAICDQMESP EEAKARKAPT IRREVVRIVT
PGTVTEDALL EAARPAWLLA LAKGGAAWLD VTSGAFETED NPDIPALMAR LDPSEIIAED
GLWPDAIEAV APRDAARRIA AAFDVASLEG FGTFTEAELR AAAMAVDYVR ATQNGRLPFL
MRPVPRGTQG VLLMDAATRR SLEILRSERG EARSTLLAAV DRTLTGAGAR ELAARLAAPL
ASLPAIQARH AAVEALRAHH EWRGSLRGAM KGAPDMARAL ARISLERYAP RDLAALRDGL
TRAEAMAGHC AGARPLPPLL ADAADALVPP ESPREELTRA LAEQLPARFE DGGVIAAGYD
GQLDAMRRLR DDARGAIAAM QMQLAEAWGV ASLKVKHHQQ MGYLAEVQAA PGEKLLRSPP
SLPGELMPQH RQTMANALRF TCGALVELDR KLSQAAEQAQ GRERAIVRHL AGLCAQAAQG
ITEAARAVAE FDVHAAAAEL ALANWCRPEM TGGADFHIQS GRHPVVEAAL TRAKGPAFVP
NDAELSAGQR LCLLTGPNMA GKSTFLRQNA LMVVLAQAGL FVPAEAARLG VVDRLFSRVG
ASDDLAGGRS TFMVEMTETA AILNQAGPRS FVILDEVGRG TATWDGLAIA WAVLEALHDR
LRCRAIFATH FHELTALAGK LPELRLATMR VREWKNEVVF LHSVGPGAAE KSWGLHVARL
AGVPRTVLGR AEAVLHALES RARQGGGVLS EELPLFAPKP AAAPDHPVLA ALATLDPDAM
SPRDAQEALY RLKALLTP
//
