ID A0A437N3X4_9SPHN Unreviewed; 415 AA.
AC A0A437N3X4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=EOE18_10630 {ECO:0000313|EMBL:RVU04617.1};
OS Novosphingobium umbonatum.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=1908524 {ECO:0000313|EMBL:RVU04617.1, ECO:0000313|Proteomes:UP000282837};
RN [1] {ECO:0000313|EMBL:RVU04617.1, ECO:0000313|Proteomes:UP000282837}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSY-9 {ECO:0000313|EMBL:RVU04617.1,
RC ECO:0000313|Proteomes:UP000282837};
RA Chen W.-M.;
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Poorly processive, error-prone DNA polymerase involved in
CC untargeted mutagenesis. Copies undamaged DNA at stalled replication
CC forks, which arise in vivo from mismatched or misaligned primer ends.
CC These misaligned primers can be extended by PolIV. Exhibits no 3'-5'
CC exonuclease (proofreading) activity. May be involved in translesional
CC synthesis, in conjunction with the beta clamp from PolIII.
CC {ECO:0000256|ARBA:ARBA00025589}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RVU04617.1}.
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DR EMBL; SACO01000007; RVU04617.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A437N3X4; -.
DR OrthoDB; 9808813at2; -.
DR Proteomes; UP000282837; Unassembled WGS sequence.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProt.
DR CDD; cd00424; PolY; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR024728; PolY_HhH_motif.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11076:SF34; PROTEIN UMUC; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF11798; IMS_HHH; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000282837}.
FT DOMAIN 9..191
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
SQ SEQUENCE 415 AA; 46333 MW; 03004B9B6E7158E9 CRC64;
MRKPTTIEHL YLDFDGFFAS VEQLRDPHLR GRPVGVIPYA GGGRTCIIAC SREAKARGVK
NIMMVDEARR LCRDIVLVPQ KPDLYRRAHN ALISEIGSVI PVDQVKSIDE VSCWLDETQR
GEPTDLAQRI KNTIRYNIGA TLTCSIGFAA NRHLAKIASD TKKPDGLTIW YPEDVPAQLA
RLKLEDIPGI GRSMVKRLAA ARVGDVPGLL ALQPKQMRAI WRNVTGERLW YALHGYAVEA
PETERNMFGH ARVLPPDQRS LDDARAIARL LLVKAARRMR RSNFYASALY LWLKGFERGW
GNMAPLGEVQ DDMAILAALS ELWERVTAVI PPTTKIMRVS VTLGELTLDT ARQPDLFAND
DKERQRCEAL SRTMDGLNSR FGQTVVSVGP WAPPAGGNVG SKISYTRIPE AEDNW
//
